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This contribution reviews theory, algorithms, and validation results for system identification of continuous-time state-space models from finite input- output sequences. The algorithms developed are autoregressive methods, methods of subspace-based model identification and stochastic realization adapted to the continuous-time context. The resulting model can be decomposed into an input-output mode
Hyperdiploidy, i.e. gain of whole chromosomes, is one of the most common genetic features of childhood acute lymphoblastic leukemia (ALL), but its pathogenetic impact is poorly understood. Here, we report a proteogenomic analysis on matched datasets from genomic profiling, RNA-sequencing, and mass spectrometry-based analysis of >8,000 genes and proteins as well as Hi-C of primary patient samples f
In new built apartments buildings with modern mechanical supply and exhaust ventilation, window opening was reported by a majority of the residents. A follow‐up study of the physical indoor environment and the perceived environment by the residents was therefore performed. The follow‐up study is included in a project which also comprises of a follow‐up of the energy use and factors related to this
Zooplankton have evolved several mechanisms to deal with environmental threats, such as ultraviolet radiation (UVR), and in order to identify strategies inherent to organisms exposed to different UVR environments, we here examine life-history traits of two lineages of Daphnia pulex. The lineages differed in the UVR dose they had received at their place of origin from extremely high UVR stress at h
Myoglobin is a primary iron, and oxygen-binding protein of muscle tissues and levels can be an important diagnostic biomarker for acute myocardial infarction, myocardial necrosis, or other cardiac diseases. The establishment of myoglobin recognition systems is important because of its protein's structural and functional values in physiology, biochemistry, and diagnostic value in some damaged muscl
BACKGROUND: Many lifestyle factors have been associated with the metabolic syndrome (MetS). However, most of these studies have not considered the potential impact of obesity and have often only investigated one lifestyle factor at the time. We aimed to investigate the interplay between body mass index (BMI) and MetS with respect to multiple lifestyle factors.METHODS: BMI and MetS [National Choles
The populist turn in national and international politics includes one common question across countries: curbing immigration and limiting the rights of migrants. In the light of these restrictive tendencies, the questions that this article seeks to address are: whether and how the European Convention on Human Rights (ECHR), as interpreted by the European Court of Human Rights (ECtHR), can be a poin
Evaniid wasps develop as solitary egg predators within the oothecae of cockroaches. Fossil evaniids are relatively common compared with most other parasitoid Hymenoptera, undoubtedly due to their searching for host cockroaches on tree trunks and thus an increased chance of being trapped in tree resin. The genus Parevania Kieffer, 1907 is widely distributed through the Old World and is also known f
In many ways can Thomas More’s vision in his classic Utopia from 1516 lend itself to describe Sweden as no longer a great power in war, as had been the case in the 17th and early 18th century, but an egalitarian nation and also in other aspects a peaceful, humanitarian example to follow. The ideal that More envisioned is to be understood as an unattainable and therefore unrealistic dream; his idea
This paper aims to simulate diesel spray flames across a wide range of engine-like conditions using the Eulerian Stochastic Field probability density function (ESF-PDF) model. The ESF model is coupled with the Chemistry Coordinate Mapping approach to expedite the calculation. A convergence study is carried out for a number of stochastic fields at five different conditions, covering both convention
This book is concerned with how search, searching and with them search engines have become so widely used that we have stopped noticing them. One of society’s key infrastructure for knowing and getting informed are computerised systems supporting the search for and locating of documents and information. The use of these systems, search engines, is curiously dispersed and centralised at the same ti
The local governments of EU member countries are attracted to the possibility of receiving EU funding. However, as the governance structures of EU funds are complex and dynamic, municipalities are increasingly drawing on the knowledge and resources of ‘EU experts’ who mediate and provide project support. This article contributes to our understanding of how EU cohesion policy is translated through
Urological problems can be caused by diseases that affect the bladder wall and its innervation. Contraction and relaxation of smooth muscle cells (SMCs) is essential for maintaining detrusor function and for emptying the bladder. It is well established that a family of regulatory proteins called Myocardin Related Transcription Factors (MRTFs) controls the property of SMCs. SMCs have a number
Aims: It has in recent years been established that epigenetic changes contribute to β-cell dysfunction and type 2 diabetes (T2D). For example, we have showed that the expression of histone deacetylase 7 (HDAC7) is increased in pancreatic islets of individuals with T2D and that increased levels of Hdac7 in β-cells impairs insulin secretion. The HDAC inhibitor MC1568 rescued this secretory impairmen
In all over the world, there have been assessed two common energy and climate strategies. One relies on improving energy efficiency and the other aims to increase the market share of renewable energy. Turkey, being an important country in terms of energy and climate issues is required to integrate energy efficiency and renewable energy strategies into energy planning to better decide on energy sec
Background: Psychiatric comorbidity is common in gambling disorder, a condition with low rates of treatment seeking. There is a paucity of documented nationwide data on gambling disorder and its co-occurring psychiatric comorbidities in the health care system. Methods: This is a nationwide register-based study of all patients aged above 18 years who were diagnosed with gambling disorder (correspon
Due to their unique optical properties, III-V nanowires are promising candidates for the development of efficient solar cells, LEDs and nanoscaled lasers. The interaction of nanowires with fluorescent molecules is also of interest, as these nanostructures can act as nanoscaled optical fibers. The light emitted by a fluorophore close to a nanowire surface can in fact couple into the supported waveg
INTRODUCTION: Hip and knee osteoarthritis is a leading cause of disability worldwide. Currently, the course of deterioration in pain and physical functioning in individuals with osteoarthritis is difficult to predict. Factors such as socioeconomic status and comorbidity contribute to progression of osteoarthritis, but clear associations have not been established. There is a need for early identifi
Isothermal titration calorimetry (ITC) is an apt tool for a total thermodynamic description of self-assembly of atypical amphiphiles such as anionic boron cluster compounds (COSAN) in water. Global fitting of ITC enthalpograms reveals remarkable features that differentiate COSAN from classical amphiphiles: (i) strong enthalpy and weak entropy contribution to the free energy of aggregation, (ii) lo
