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With the ever increasing amount of genomic data available, the interest for generating biochemical pathways has grown tremendously. So far, mainly complete genomes have been used to reconstruct the biochemical pathways and their associated interactions. However, a large number of low coverage genomes, as well as other sources of partial genomic data, are currently available for many organisms. In
Popular Abstract in Swedish Bröstcancer är den vanligaste cancerformen bland kvinnor i Sverige. Mer än 7000 kvinnor insjuknar varje år i bröstcancer, och cirka 1500 dör i sjukdomen. Incidensen av bröstcancer har stigit kontinuerligt sedan 1970-talet, och man uppskattar att en av tio kvinnor i Sverige kommer att utveckla bröstcancer någon gång under sin livstid. Den relativa överlevnaden i sjukdomeCancer is a genetic disease that arises when a cell acquires unlimited growth potential through a series of mutational events, which target genes essential for normal cell control and maintenance. Breast cancer is one of the most frequent malignancies in women worldwide, and it is characterized by heterogeneous tumor biology, histological subtypes, variable prognosis and variable responsiveness to
This article outlines experimental laboratory and field studies on creep of young or mature High Performance Concrete, HPC, carried out between 1991 and 1999. For this purpose about 400 cylinders made out of 8 mix compositions of HPC were studied in the laboratory. Half the number of HPC was sealed; half of the studies were carried out on air-cured HPC. Parallel tests on strength, internal relativ
Aliphatic straight-chain dicarboxylic acids have been identified as common water-soluble organic components of atmospheric aerosols. To model the partitioning of such compounds between gas and particle phase in the atmosphere, information about their vapor pressures is essential. In this work, vapor pressures of C3-C9 dicarboxylic acids are derived from measured evaporation rates of submicron aero
Popular Abstract in SwedishEn del av Ortonys teorimodell angående den kognitiva strukturen hos emotioner testades på svenska gymnasieelever. Den del av teorin som användes i föreliggande studie handlade om de emotioner som tillskrivs den som utfört s.k. orätta handlingar. De eventuella känslor som man får när man utfört en orätt handling kallar Ortony för "self reproach" emotioner. Detta begrepp sThe purpose of this study was to test parts of Ortony's theoretical model relating to the cognitive structure of emotions in Swedish upper secondary school students. That part of the model, which was appropriate for the present study, deals with emotions attributed to the person who has perpetrated what is referred to as blameworthy actions. Ortony calls the possible emotions that you experience w
The CSF is often regarded as merely a mechanical support for the brain, as well as an unspecific sink for waste products from the CNS. New methodology in receptor autoradiography, immunohistochemistry and molecular biology has revealed the presence of many different neuroendocrine substances or their corresponding receptors in the main CSF-forming structure, the choroid plexus. Both older research
With the advent of massive online encyclopedic corpora such as Wikipedia, it has become possible to apply a systematic analysis to a wide range of documents covering a significant part of human knowledge. Using semantic parsers, it has become possible to extract such knowledge in the form of propositions (predicate―argument structures) and build large proposition databases from these documents. Th
Popular Abstract in Swedish Vi tänker oss i allmänhet att vår upplevelse av drömmen är lik vår upplevelse av vår vakna verklighet i så måtto att drömmen presenterar sig som en värld som vi som drömmare tar för verklig och som vi på olika sätt interagerar med. I denna avhandling tittar jag närmare på denna uppfattning och granskar hur väl den harmonierar med vad vi nu anser oss veta om hur hjärnan/This treatise examines what I call the ‘traditional view’ on the phenomenology of dreaming. According to this view, dreams are experienced in more or less the same way as waking reality – that is, our experience of “being-in-the-dream” is very much like our experience of “being-in-the-world”. The traditional view will be examined from three different standpoints: phenomenology, cognitive science a
Ioannes Dantiscus' letters are a source of singular importance for 16th century European history. Dantiscus was a great traveller who got first-hand information from most parts of Europe, and his correspondence conveys to us today a vivid and varied picture of Early Modern Europe. The list of his correspondents is a name-dropper's dream: Copernicus, Philip Melanchton and Hernan Cortez, to mention
BACKGROUND: Uganda has reduced its prevalence of HIV/AIDS from 18 to 6.5% within a decade. An important factor behind this might have been the response from faith-based voluntary organizations, which developed social capital for achieving this. Three behaviors have been targeted: Abstinence, Being faithful, and Condom use (the ABC strategy). The aim of this study was to explore the association bet
When statistical linkage to a certain chromosomal region has been found, it is of interest to develop methods which quantify the accuracy with which the disease locus can be mapped. In this paper, we investigate the performance of three different types of confidence regions with asymptotically correct coverage probability as the number of pedigrees grows. Our setup is that of a saturated map of ma
BACKGROUND: Substance use disorders have repeatedly been found to lead to premature death, i.e. drug-related death by disease, fatal intoxications, or trauma (accidents, suicide, undetermined suicide, and homicide). The present study examined the relationship between multi-drug substance use and natural and unnatural death. METHODS: All consecutive, autopsied patients who had been in contact with
PDGFB is a growth factor which is vital for the completion of normal prenatal development. In this study, we report the phenotypic analysis of placentas from mouse conceptuses that lack a functional PDGFB or PDGFRbeta gene. Placentas of both types of mutant exhibit changes in the labyrinthine layer, including dilated embryonic blood vessels and reduced numbers of both pericytes and trophoblasts. T
Popular Abstract in Swedish Avhandlingen är en studie av kvinnors brevskrivning i Sverige under 1700-talet. Breven är skrivna av ett antal kvinnor från de högre samhällsskikten (adel och borgerskap) under 1780- och 1790-talen. Flertalet av breven är skrivna på svenska, men några också på franska. Huvudsyftet med avhandlingen är att undersöka relationen mellan idén om att kvinnor skrev annorlunda,
It is a well known fact that since the 1960s, Sweden and Holland have developed completely different types of drug policy. But there are a number of misconceptions as to what the differences consist in and how they have arisen. My contribution to this anthology involves elucidating these differences. In the context of international discussions of drug policy, the policies followed by Sweden and Ho
Popular Abstract in Swedish Syftet med min avhandling har varit att visa på några viktiga drag som framträder vid en undersökning och en jämförelse av fyra etablerade poeter från 1970-talets diktargeneration i Grekland: Michalis Ganas, Maria Kirtzaki, Tzeni Mastoraki och Kostas Papageorgiou. Genom att deras litterära skapande satts i en tydlig relief mot relevanta politiska, historiska och samhäll
