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Familial risk of ovarian cancer is well-established but whether ovarian cancer clusters with other cancers and the clusters differ by histology remains uncertain. Using data from the Swedish Family-Cancer Database, we explored familial associations of ovarian cancer with other cancers with a novel approach; relative risk for (histology-specific) ovarian cancer was estimated in families with patien
According to results of a recent literature search performed by the European Academy of Dermatology and Venereology (EADV) Task Forces (TF) on Quality of Life and Patient Oriented Outcomes (QoL and PO) and Acne, Rosacea and Hidradenitis Suppurativa (ARHS), most of the publications where health-related (HR) QoL of acne patients was studied were clinical trials. Members of the EADV TF on QoL and PO
Haemophilia A and B diagnosis and disease severity classification are determined on the basis of results from factor VIII (FVIII) and factor FIX (FIX) activity assays, respectively. These assays are also used for potency labelling, postinfusion monitoring of factor replacement products and testing for FVIII/FIX inhibitors. This review focuses on activated partial thromboplastin time (APTT)-based o
Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic
A central element of assimilation theory is that increasing time and number of previous immigrant generations in a host country leaves immigrants and their children more integrated and capable of navigating the host society. However, the underperformance of some immigrant groups in Sweden calls into question this relationship. Additionally, many studies regard intermarriage as an outcome of immigr
Astrocytes support normal brain function, but may also contribute to neurodegeneration when they become reactive under pathological conditions such as stroke. However, the molecular underpinnings of this context‐dependent interplay between beneficial and detrimental properties in reactive astrogliosis have remained incompletely understood. Therefore, using the RiboTag technique, we immunopurified
In order to observe a patent application at the firm level, two conditions need to be met: new products need to be of patentable quality, which depends both on the degree of novelty of innovations and on the total number (portfolio) of innovations; and the benefits of patents need to be higher than the costs of owning them. Analyzing the patent propensity of small and large UK firms using a novel
Most migrating birds need to stopover in between flights in order to refuel. Lately, additional purposes of stopover have been suggested, including physiological recovery from metabolically demanding migratory flight. One apparently unavoidable, but harmful physiological effect of migratory flight is increased oxidative damage to lipids and proteins. We here, for the first time, tested whether mig
Spent sulfite liquor (SSL) is a byproduct of the sulfite pulping process of wood. SSL usually contains monosugars and lignosulfonates, which are fermented to produce ethanol and dried to generate lignosulfonate salts. However, the SSL that was used in this work was derived from the first step of a 2-step sulfite pulping process of softwood under mild pulping conditions in the first stage of cookin
BACKGROUND: Measuring emotional status objectively is challenging, but voice pattern analysis has been reported to be useful in the study of emotion.OBJECTIVE: The purpose of this pilot study was to investigate the association between specific sleep measures and the change of emotional status based on voice patterns measured before and after nighttime sleep.METHODS: A total of 20 volunteers were r
Thoughtful use of simplifying assumptions is crucial to make systems biology models tractable while still representative of the underlying biology. A useful simplification can elucidate the core dynamics of a system. A poorly chosen assumption can, however, either render a model too complicated for making conclusions or it can prevent an otherwise accurate model from describing experimentally obse
The interplay between spin-orbit coupling and structural inversion symmetry breaking in solids has generated much interest due to the nontrivial spin and magnetic textures which can result. Such studies are typically focused on systems where large atomic number elements lead to strong spin-orbit coupling, in turn rendering electronic correlations weak. In contrast, here we investigate the temperat
The morphological structure of the nervous system is ultimately the basis of its function. Analyses of the anatomical layout of brain areas, single neuron morphologies, and the synaptic connectivity of neurons are therefore essential for a comprehensive understanding of the computational processes implemented in neuronal networks. Insect brains have long served as models to examine neuronal circui
Peripheral nerve injuries are difficult to treat, and the clinical outcome after surgical repair and reconstruction is still insufficient, particularly concerning recovery of sensory function. To improve the clinical treatment strategies, experimental models are used to systematically examine the mechanisms behind nerve regeneration and assess the improvement of nerve regeneration by introduction
A fundamental question for economic sociology is: how are prices set? In economic sociological theory, a price is generally conceptualized either in terms of the performative construction of economy (e.g. a market device), or in terms of co-ordinational effects of power relations between buyers and sellers (e.g. the effect of social structures and institutions). In this paper, I set out to show ho
For some time, tourism researchers have sought to examine and theorise types of collaborative exchange and the characteristics of relational work in tourism. Different ontological and epistemological framings, and associated language games have contributed to a fragmented body of knowledge. In this paper, we argue that the new term ‘co-creation’ is part of this language game, and efforts to date h
There is a growing appreciation of the need and urgency to study and document mobility and energetics among extant hunter-gatherers. An increasing number of studies investigate the spatial and biophysical properties of hunter-gatherer movement, in order to gain a deeper understanding of such things as human energy expenditure and efficiency in human foraging behavior. So far, however, this researc
