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Polyamine analogue treatment results in growth inhibition and sometimes in cell death. Therefore, polyamine analogues are considered in the treatment of cancer; however, the cellular properties that govern sensitivity are not known. The objective of this study was to elucidate molecular mechanisms behind apoptosis induced by the polyamine analogue N, N-diethylnorspermine (DENSPM). Four different b
In this study, design considerations for ultra low voltage (ULV) standard-cell based memories (SCM) are presented. Trade-offs for area cost, leakage power, access time, and access energy are discussed and realized using different read logic styles, latch architecture designs, and process options. Furthermore, deployment of multiple threshold voltages (Vth) options in a single standard-cell/bitcell
Background: Asthma and allergic airway inflammation are associated with persistent structural alterations in the bronchi, i.e. airway remodeling. Previous studies have shown that during allergic airway inflammation, similar structural alterations may also be evoked in the pulmonary circulation. However, it remained unknown whether remodeling of the pulmonary circulation is as persistent as airway
Reduced plant height and culm robustness are quantitative characteristics important for assuring cereal crop yield and quality under adverse weather conditions. A very limited number of short-culm mutant alleles were introduced into commercial crop cultivars during the Green Revolution. We identified phenotypic traits, including sturdy culm, specific for deficiencies in brassinosteroid biosynthesi
Background:Familial nervous system cancers are rare and limited data on familial aspects are available particularly on site-specific tumours.Methods:Data from five Nordic countries were used to analyse familial risks of nervous system tumours. Standardised incidence ratios (SIRs) were calculated for offspring of affected relatives compared with offspring of non-affected relatives.Results:The total
The clinical consequence of chronic Pseudomonas aeruginosa colonization in cystic fibrosis (CF) varies between individuals for unknown reasons. Auto-antibodies against bactericidal/permeability increasing protein (BPI-ANCA) are associated with poor prognosis in CF. We hypothesize that there is a correlation between the presence of BPI-ANCA, the properties of the colonizing bacteria and the clinica
Structural flexibility is an essential attribute, without which few proteins could carry out their biological functions. Much information about protein flexibility has come from x-ray crystallography, in the form of atomic mean-square displacements (AMSDs) or B factors. Profiles showing the AMSD variation along the polypeptide chain are usually interpreted in dynamical terms but are ultimately gov
ObjectivesTo assess the in vitro antibiotic susceptibility of Enterococcus faecalis in biofilms.MethodsE. faecalis isolates were from infections of prosthetic hip and knee joints. Minimal biofilm eradication concentrations (MBECs) for ampicillin, vancomycin, linezolid, ciprofloxacin and rifampicin, alone and in combinations, were determined. E. faecalis biofilms in microtitre plate wells or on bea
A major problem in clinical lung transplantation is the shortage of donor lungs. Only about 20% of donor lungs are accepted for transplantation. We have recently reported the results of the first six double lung transplantations performed with donor lungs reconditioned ex vivo that had been deemed unsuitable for transplantation by the Scandiatransplant, Eurotransplant, and UK Transplant organizati
Immunotherapy has brought hope for cancer treatment, but its clinical success remains limited. Recently, overexpression of the transcription factors PU.1, IRF8 and BATF3 (PIB) was shown to induce direct reprogramming of tumor cells into antigen-presenting type 1 conventional dendritic cells (cDC1s), a rare subset of immune cells with pivotal role in anti-cancer immunity. This strategy might open a
This edited volume discusses the emergence and development, and in some cases also the disappearance, of social movements and activism in the Swedish 1980s. The introductory chapter gives the background and aim of the volume and discusses why the Swedish case is interesting from a European perspective. The 1980s have often been described as a decade when the radical social movements of the 1960s a
Under arid natural conditions, soil water content governs and limits the number and size of perennial plant species. Thus, plant-available soil water is the main constraint for sustainable control of desert encroachment. To evaluate possibilities for re-vegetation of bare sand surfaces, soil water and temperature patterns for typical sand dunes in a desert climate were investigated. Bare and veget
This paper develops a novel sparse direction-of-arrival (DOA) estimation technique that avoids the common requirement of hyperparameters, which are typically difficult to set suitably in practice. Using the presented minimum mean-square error (MMSE) estimation framework, we propose a computationally efficient super-resolution DOA estimator that is implemented using an alternate updating of the spa
In this study two functionally graded cemented carbide samples with gradients in both composition and grain size have been produced and studied. The two samples are manufactured by local addition of TiC to a pressed WC-Co green body prior to sintering. The two samples differ only by the in-going WC particle size, where one sub-micron and one coarse WC particle size is used. The Ti, Co, and C conce
This study investigates the relationship between changes in the frequency of dwell time delays and passenger flow characteristics and the frequency of railway service during the COVID-19 pandemic. To do so we make use of automatic passenger count data from commuter trains in Southern Sweden. Our findings show that the frequency of dwell time delays decreased under COVID-19 conditions compared to t
Pallet racks used in industry are often exposed to large loads, and in some casesresistance to failure is reduced by damage or inadequate handling. The present study was undertaken with the aim of investigating a number of different parameters of importance for the load-carrying capacity of pallet racks. Mainly numerical studies, using the finite element method, are performed, but some experimenta
Thin YBa2Cu3Ox films were grown on SrTiO3 or LaAlO3 single crystals by dc-magnetron reactive sputtering in argon/oxygen gas mixtures. Deposition temperatures ranged from 540 °C to 780 °C. After deposition and subsequent cool down, films grown above 680 °C are superconducting below 86–88 K. All films are oriented with the [001] direction parallel to the [001] substrate normal. The best films have c
Interior automotive plastic components are often manufactured by injection moulding since this technique enables cost-efficient manufacturing, large design freedom, and easy integration of functions. However, to obtain a high-quality impression, it is important to produce components with uniformity in texture, colour, and gloss. Unfortunately, this is rather difficult since a large number of mater
Interest in learning in mature adulthood has become increasingly important as attention has been focused on what is seen to be an impending crisis in the near future, i.e., shortage of labour due to the ever-growing number of elderly and decreasing nativity rates. In some circles "alarmist demographics" have overshadowed an arguably more important concern, that of providing for aging individuals'
Popular Abstract in Swedish Inom området datorgrafik undersöker man hur virtuella scener kan omvandlas till verklighetstrogna bilder. För interaktiva miljöer, som exempelvis datorspel, måste en ny bild vara genererad och klar att visas på skärmen mellan 30-60 gånger i sekunden för att upplevelsen ska kännas responsiv och för att rörelser ska flyta på ett naturligt sätt. För att datorn ska hinna meThe field of computer graphics refers to the use of computers to generate realistic-looking images from virtual scenes. Graphics processing units use an algorithm known as rasterization to compute images of scenes viewed from a virtual camera. The commonly used pinhole camera model does not account for the imperfections that stem from the physical limitations in real-world cameras. This includes,
