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Background Companies producing premium products with high quality and long product life can experience challenges when trying to penetrate price-sensitive customer segments on emerging markets due to a high product price. One way to achieve growth in these segments is to introduce new innovative business models. From the theory of circular economy, a concept combining sustainable and economi
Domstolarna ställs ofta inför problematiken att värdera muntliga utsagor. Ibland är en utsaga den enda bevisningen i ett mål och det är ytterst viktigt att bevisvärderingen genomförs på ett grundligt sätt. Det finns inga lagregler som styr hur bevisvärderingen ska gå till. Trots principen om fri bevisprövning finns det dock krav på objektivitet och att värderingen sker utifrån allmänna erfarenhetsCriminal courts often face the complexity that follows the analysis of verbal statements. In some cases a statement constitute the only evidence and it is vital to carry out a thorough valuation of the evidence. Despite the lack of written law and the principle of free trial of evidence there is still a demand for objectivity and the use of general knowledge. The Supreme Court has written out that
Background: Cranial irradiation is a common therapy for the treatment of brain tumors, but unfortunately patients suffer from side effects, particularly cognitive impairment, caused by neurodegenerative and neuroinflammatory mechanisms. Finding a therapeutic agent protecting hippocampal neurons would be beneficial. Fingolimod (FTY720), a sphingosine-1-phosphate receptor modulator approved for mult
In medieval Scandinavia, parchment was a crucial writing material for everything from property deeds and judicial matters to religious works and account keeping. As society became more and more invested in literacy, the demand for parchment grew. However, the supply of animals for parchment could not increase to the same extent without great changes in animal husbandry. This thesis explores how me
Importance: The ability to predict sudden cardiac death (SCD) in children and adolescents with hypertrophic cardiomyopathy (HCM) is currently inadequate. Late gadolinium enhancement (LGE) by cardiovascular magnetic resonance (CMR) imaging is associated with SCD events in adults with HCM. Objective: To examine the prognostic significance of LGE in patients with HCM who are younger than 21 years. De
Popular Abstract in Swedish Molekylär förädling på sockerbeta, Transformation, Transgene utsläckning, Virus och Herbicid resistensThe main objectives in sugar beet breeding, are to improve yield, quality and to develop disease resistance. The disease resistance may be developed either by conventional, or molecular breeding techniques. The molecular breeding techniques include, methods to genetically engineer plants for expression of introduced genes. A necessity for the production of transgenic plants, is the development of
Type 2 diabetes has become a leading health problem throughout the world. The escalating epidemic of type 2 diabetes is believed to result from a collision between inherent biological susceptibilities (genotypes) and a shift toward dietary habits and lifestyle that promote obesity over the past several decades; the transition from “traditional” to modern “obesogenic” lifestyles is characterized by
Background and aims After assessing the risk for cardiovascular disease (CVD) based on traditional risk factors, decisions concerning lipid lowering therapy might remain uncertain. To investigate whether lipoprotein subfraction levels could aid these decisions, we assessed the association between lipoprotein subfractions and CVD, after adjustment for traditional risk factors including standard lip
BACKGROUND: Achieving universal health coverage (UHC) requires health financing systems that provide prepaid pooled resources for key health services without placing undue financial stress on households. Understanding current and future trajectories of health financing is vital for progress towards UHC. We used historical health financing data for 188 countries from 1995 to 2015 to estimate future
There is an extensive research that explores the reproduction of transnational communities and relations, with a particular focus on locality, identity and culture. However, the existing literature on transnational migration is largely based on the case studies of immigrant communities living in the United States and Western Europe, while not much has been said about the transnational practices of
OBJECTIVES: To evaluate the influence of the main immunological markers on the disease phenotype at diagnosis in a large international cohort of patients with primary Sjögren's syndrome (SjS).METHODS: The Big Data Sjögren Project Consortium is an international, multicentre registry created in 2014. As a first step, baseline clinical information from leading centres on clinical research in SjS of t
Software developers are gaining increasing influence within every company they work for and work with. Engaging at C-level is no longer sufficient: the software developer is now a powerful force in decision-making.This book is intended to be the “textbook” for those working - or starting - in developer marketing. It will teach you how to engage with developers to build a two-way relationship that
The chemosensory gene families of insects encode proteins that are crucial for hostlocation, mate finding, oviposition, and avoidance behaviors. The insect peripheralchemosensory system comprises odorant receptors (ORs), gustatory receptors (GRs),ionotropic receptors (IRs), odorant binding proteins (OBPs), chemosensory proteins(CSPs), and sensory neuron membrane proteins (SNMPs). These protein fam
Popular Abstract in Swedish Vatten- och läskflaskor av polyetylentereftalat, PET, kan både återanvändas (återfyllbara flaskor) och/eller återvinnas. Vid återvinning kan materialet användas för tillverkning av nya flaskor, sk closed-loop recycling. I både återfyllbara flaskor och flaskor som innehåller återvunnet material kan det förekomma ämnen som tidigare trängt in i plasten. Dessa kan antingen The reuse and closed-loop recycling of food packaging was studied in order to assess consumer safety and the sensory quality (e.g. taste and smell) of packaged food. Polyethylene terephthalate (PET) beverage bottles that were refillable or that contained recycled material, either in direct contact or with a functional barrier protecting the food, were investigated with focus on odorous compounds f
Popular Abstract in Swedish En av de viktigaste substanserna i vår kropp är proteiner, också kallade äggviteämnen. Proteiner har en mängd olika uppgifter i kroppen, de finns i våra celler där de har olika uppgifter såsom att fungera som enzymer, transportörer, signalsubstanser, eller som skyddsfaktorer. Proteiner ingår också som viktiga beståndsdelar i vävnaderna mellan cellerna och finns dessutomPathogenic bacteria express a wide array of surface proteins that interact with the environment. Many of these proteins are believed to be important for the virulence. This thesis deals with the binding of immunoglobulins (Ig) and complement regulating proteins to certain bacterial surface proteins. Protein L from Peptostreptococcus magnus binds to Igk-light chains while protein A from Staphylococ
Classical evolutionary life history concerns questions such as optimal timing of maturation, life span and number of offspring. These questions have mostly been studied theoretically under the assumption that the environment is stable and without taking into account frequency and density dependence. Life history theory is the basis for my thesis, in which I have studied the evolution of different
Background: The whitefly Bemisia tabaci (Hemiptera: Aleyrodidae) is among the 100 worst invasive species in the world. As one of the most important crop pests and virus vectors, B. tabaci causes substantial crop losses and poses a serious threat to global food security. Results: We report the 615-Mb high-quality genome sequence of B. tabaci Middle East-Asia Minor 1 (MEAM1), the first genome sequen
