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An airfreight container with automated instruments for measurement of atmospheric gases and trace compounds was operated on a monthly basis onboard a Boeing 767-300 ER of LTU International Airways during long-distance flights from 1997 to 2002 (CARIBIC, Civil Aircraft for Regular Investigation of the Atmosphere Based on an Instrument Container, http://www.caribic-atmospheric.com). Subsequently a m
A series of triclinic Fe1−xAlxVO4 phases with 0 <= x <= 1 were prepared and used in the oxidation of methanol to formaldehyde. The activity measurements revealed that both the activity and especially the selectivity to formaldehyde increased with time of operation for at least 16 h, indicating restructuring of the catalysts. Characterisation of the catalysts with XRD, XANES, and electron microscop
We demonstrated previously that leukotriene D-4 (LTD4) regulates proliferation of intestinal epithelial cells through a CysLT receptor by protein kinase C (PKC)epsilon-dependent stimulation of the mitogen-activated protein kinase ERK1/2. Our current study provides the first evidence that LTD4 can activate 90-kDa ribosomal S6 kinase (p90(RSK)) and cAMP-responsive element-binding protein (CREB) via
Objective. Compare the initial stability at the fusion site of ankle arthrodesis fixed with two and three screws. Design. Finite element models of ankle arthrodesis were developed from computed tomography images. Two-screw constructs were augmented with a third screw in different orientations and Subjected to loads likely to affect the ankle postoperatively. Background More stable fixation seems t
INTRODUCTION: An increasing number of sub-Saharan African countries are implementing national health insurance schemes (NHISs) to support the aspiration of universal health coverage (UHC). A growing body of literature recognises the private sector role in improving NHIS equity in service access, public provider complementarity and overall member satisfaction. Zambia has implemented the NHIS since
In 2017, 255 of Sweden's 290 municipalities reported a shortage of residential housing (Boverket, 2017). The answer is to build more. Due to urbanization pressure, concerns for saving valuable agricultural land, growing national and EU demands on energy-efficiency, there is an increasing number of new and dense urban developments. Daylight issues seem to have been of little concern in developm
Ett köp av en bostadsrätt är vanligt förekommande i dagens samhälle. År 2017 fanns det 2,4 miljoner flerbostadshus i Sverige, av dessa var cirka 41 % bostadsrätter. På grund av den stora omfattningen och de höga priserna som bostadsrätter säljs för är det troligtvis av stort intresse att veta hur felbedömningen av en bostadsrätt går till i praktiken. När en person köper en bostadsrätt köper han A purchase of a tenant owned apartment is commonly found in today's society. In 2017 there were 2.4 million multi-family residential in Sweden and around 41 % of those were tenant owned apartments. Due to the large extent and the high prices tenant owned apartment is being sold for; it is probably of great interest to gain knowledge of how faults in the purchased tenant owned apartments are re
Introduction: Several thrombin-generation tests are available, but few have been directly compared. Our primary aim was to investigate the correlation of two thrombin generation tests, thrombin generation assay-calibrated automated thrombogram (TGA-CAT) and INNOVANCE ETP, to factor VIII levels (FVIII:C) in a group of patients with hemophilia A. The secondary aim was to investigate inter-laboratory
Background: Non-beta-hemolytic streptococci (NBHS) are a common cause of infective endocarditis (IE). Echocardiography is used to diagnose IE, but it is not known which patients with NBHS bacteremia should undergo echocardiography.Method: Medical records of patients with NBHS bacteremia in southern Sweden from 2012-2014 were studied retrospectively. The patients were divided into two cohorts. In t
About 8000 Swedish women are diagnosed with breast cancer each year, and around 1500 die from the disease. Triple-negative breast cancer (TNBC) constitutes 7-14% of all breast cancer and is characterized by an aggressive phenotype with poor prognosis and no targeted therapy available. The aim of this thesis was to evaluate new potential prognostic biomarkers in breast cancer, and with special focu
There is growing evidence that the environment experienced by one generation can influence phenotypes in the next generation via transgenerational plasticity (TGP). One of the best-studied examples of TGP in animals is predator-induced transgenerational plasticity, whereby exposing parents to predation risk triggers changes in offspring phenotypes. Yet, there is a lack of general consensus synthes
Popular Abstract in Swedish De befintliga terapier som finns att tillgå mot hjärntumörer, t. ex strålning, kemoterapi och kirurgi, har varit utan framgång och få patienter lever längre än två år efter diagnostisering. Vi har försökt att etablera en ny terapi mot hjärntumör, som använder kroppens eget immunsystem för att lokalisera och avdöda tumörceller. Kroppens immunsystem innehåller olika celltImmunotherapy is a new promising approach in cancer treatment. In the future, it will hopefully offer an alternative to existing brain tumors treatments, which are unable to cure. We have established an experimental, low immunogenic, brain tumor model in the rat. We have increased tumor cell immunogenicity with mutagen treatment or transfection of IFN-g. Mutagen treated glioma cells (tum-) could c
Popular Abstract in English Among the forms of life found in extreme environments (e.g. high temperatures ‘thermo’ and oxygen deficient ‘anaerobe’), the thermoanaerobic bacteria emerge as a highly evolved and interesting subject of study. Bacteria living as microbial mats in decaying plant material possess a great potential not only to degrade complex biomass but also to produce special chemicals.A novel ethanol-producing thermoanaerobe Caloramator boliviensis 45BT (=DSM 22065T, =CCUG 57396T) was isolated from a hot spring of the Bolivian highlands. C. boliviensis possesses the ability to utilize a wide range of substrates and can efficiently convert hexoses and pentoses into ethanol with concomitant production of acetate, carbon dioxide and hydrogen as by-products of fermentation. However
We have investigated whether alchemical free-energy perturbation calculations of relative binding energies can be sped up by simulating a truncated protein. Previous studies with spherical nonperiodic systems showed that the number of simulated atoms could be reduced by a factor of 26 without affecting the calculated binding free energies by more than 0.5 kJ/mol on average (Genheden, S.; Ryde, U.
PhD training in academic labs offers the foundation for the production of frontier knowledge workers, indispensable for the modern knowledge-based society. Nonetheless, our understanding on PhD training has been insufficient due to limited access to the inside of academic labs. Furthermore, early careers of PhD graduates are often difficult to follow, which makes the evaluation of training outcome
Background and purpose — The number of patients where shoulder hemiarthroplasty (SHA) is an option is still substantial. Descriptive analyses performed by the Swedish Shoulder Arthroplasty Registry (SSAR) showed that while patients receiving SHA designs, i.e. resurfacing hemi (RH) and stemmed hemi (SH), reported similar shoulder functionality and quality of life, the revision rate for RH (12%) was
The contribution of host genetic and nongenetic factors to immunological differences in humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral-induced immune transcriptional profiles in an age- and sex-balanced cohort of 1,000 healthy individuals and searched for the determinants of immune response variation. We found that age and sex affected the transcriptional respo
Background: This prospective study focuses on factors associated with arterial damage in children with type 1 diabetes (T1D). Materials and Methods: Eighty children and adolescents with T1D (mean age 15, range: 8-20 yrs; mean diabetes duration 7, range: 0.5 to 19 years) were investigated twice, approximately 2 years apart, for carotid artery intima-media thickness (cIMT) and compliance (CAC), flow
Background: TMEM199 deficiency was recently shown in four patients to cause liver disease with steatosis, elevated serum transaminases, cholesterol and alkaline phosphatase and abnormal protein glycosylation. There is no information on the long-term outcome in this disorder. Results: We here present three novel patients with TMEM199-CDG. All three patients carried the same set of mutations (c.13-1
