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Objectives: Many countries have an aging population, and it is thus likely that Parkinson's disease (PD) will become an increasing health problem. It is important to ensure this group can use their resources in the best way possible, including remaining in the work market. This study aimed to investigate workforce participation and daily activities among patients with PD receiving device-aided the
BACKGROUND: The existence of a link between inflammation in upper and lower airways is well established. It may therefore be assumed that the nose could be used to study inflammatory events in the lower airways. OBJECTIVE: This study aimed to evaluate a lipopolysaccharide (LPS) nasal challenge model by investigating the effect of the CXCR2 inhibitor AZD8309 on neutrophilic inflammation. METHODS: A
Abstract Background: The metabolic syndrome is regarded as an important risk factor for diabetes mellitus and cardiovascular disease. Metabolic syndrome could be associated with impaired quality of life (QoL). Methods: The Women's Health in the Lund Area (WHILA) project covers 10,766 women born between December 2, 1935, and December 1, 1945, living in the Lund area, of Sweden by December 1, 1995.
Background: There is an evident need for improved management of elderly patients with trauma in order to avoid common and troublesome complications such as delirium. The aim of this study was to investigate whether an implementation of a multi-factorial program including intensified pre-hospital and perioperative treatment and care could reduce the incidence of delirium in elderly patients with hi
BACKGROUND: The early detection of circulatory failure in patients with sepsis is important for successful treatment. Heparin-binding protein (HBP), released from activated neutrophils, is a potent inducer of vascular leakage. In this study, we investigated whether plasma levels of HBP could be used as an early diagnostic marker for severe sepsis with hypotension. METHODS: A prospective study of 2
Preclinical studies have indicated that there is only partial cross-resistance between cisplatin and oxaliplatin. The molecular background for this is incompletely known. To investigate the differences in resistance, we rendered a colon cancer cell line (S1) resistant against cisplatin and oxaliplatin and characterized the subclones with regard to cross-resistance, platinum uptake, and gene expres
PURPOSE: Histologic grade is currently the best predictor of clinical course in chondrosarcoma patients. Grading suffers, however, from extensive interobserver variability and new objective markers are needed. Hence, we have investigated DNA copy numbers in chondrosarcomas with the purpose of identifying markers useful for prognosis and subclassification. EXPERIMENTAL DESIGN: The overall pattern o
Amyloid β peptide (Aβ42) assemblies are considered central to the development of Alzheimer's disease, but the mechanism of this toxicity remains unresolved. We screened protein microarrays with on-pathway oligomeric Aβ42 to identify candidate proteins interacting with toxic Aβ42 species. Samples prepared from Alexa546-Aβ42 and Aβ42 monomers at 1:5 molar ratio were incubated with the array during a
Den svenska straffmyndighetsåldern innebär att barn under 15 år som begår brott inte kan dömas till någon påföljd. Det finns däremot en process vid namn bevistalan som kan pröva om ett barn under 15 har begått ett allvarligt brott. Denna återfinns i 38 § LUL. Bevistalans syfte vid dess tillkomst var att ge barnavårdsorganen ett gott underlag för deras arbete. 1 juli 2023 trädde en lagändring i kraThe Swedish age of criminal responsibility means that children under 15 who commit offences cannot be sentenced to any penalty. There is, however, a process in § 38 LUL that can determine whether a child under 15 has commit-ted a serious crime, called an evidentiary proceeding. At the time of its crea-tion, the purpose of an evidentiary proceeding was to provide the child wel-fare authorities with
För att motverka den globala uppvärmningen sker i nuläget en övergång till förnybara energikällor, bland annat genom att injicera biometan i naturgasnätet. Integrationen av gas från olika källor har dock lett till ett problem: svavelutfällningar. Detta fenomen kan leda till att rör och utrustning går sönder och inte fungerar som de ska, samt en hälsorisk för operatörerna. År 2021 upptäcktes svavTo mitigate global warming, a shift towards renewable energy sources is in motion, including introducing biomethane into natural gas grids. However, the integration of gas from various sources has led to a problem known as elemental sulphur deposition. This phenomenon may lead to the breakdown and malfunction of pipes and equipment, posing health hazards to operators. In 2021 solid sulphur depos
Under senare år har det både i Sverige, Danmark och Norge förekommit ett stort antal fall där tilltalade invänt att de befunnit sig i somnambula tillstånd och därmed inte kan hållas straffrättsligt ansvariga för sina gärningar. Trots att de skandinaviska ländernas hantering av sömninvändningar görs utifrån olika rättsliga utgångspunkter, har de gemensamt att det vid bedömningen är fråga om subjektIn recent years, there have been a number of cases in Sweden, Denmark and Norway where defendants have made the objection that they were in a somnambulistic state, and therefore cannot be held criminally responsible for their actions. Despite the Scandinavian countries' assessments being made according to different laws, they all make an assessment concerning subjective culpability. While only
Hematopoietic stem cells (HSCs) are recognized for their ability to self-renew and create more stem cells while also being able to differentiate into all different types of blood cells. Stem cells can do symmetric or asymmetric divisions but the biological relevance of different types of divisions is still unclear. Steady state HSCs have been found to perform both symmetric and asymmetric division
Tissue shortage for lung transplantation remains a problem worldwide as lung transplantation is often the only available option with numerous possible complications. Generating lung tissue ex-vivo has been proposed as one way to potentially overcome this shortage. For this, tissue engineering is one potential strategy to either repair, replace or regenerate damaged tissue and organs. In this thesi
This thesis presents a comprehensive study of performance characterization and quality control (QC) for the ATLAS Inner Tracker (ITk) silicon strip modules, undertaken in preparation for the High-Luminosity Large Hadron Collider (HL-LHC) upgrade. The work focuses on two aspects: test beam campaigns and thermal cycles. During the test beam campaigns at DESY in October and December 2024, unirradiate
This thesis aims to describe and discuss the nomination processes within the political parties represented in the Swedish parliament today. It describes the guidelines for each party’s nomination process and discusses the placement and presentation of candidates on the ballot paper. The processes is analysed through earlier research on representation and strategic party politics in a multiparty-sy
The importance of reading : a Master’s Thesis about literacy and librarians’ motivational reading strategies towards children and teenagers. The public literacy debate has exploded all over Swedish media since PISA published their report at the end of 2013 with the result that politicians, teachers and parents suddenly have shown a lot more interest in what and how young people read. The report h
Framställningen syftar till att utreda och problematisera den svenska minerallagstiftningen avseende förfarandet då Bergsstaten meddelar beslut om undersökningstillstånd. Författaren intar en kritisk hållning till att lagen saknar förutsättningar att beakta motstående intressen, liksom till mineral-intressets starka position som allmänt intresse. Valda delar ur minerallagstiftningens historia belThis paper aims to investigate and problematize the Swedish mineral act in regard to the Mining Inspectorate’s (Bergsstaten) procedure for granting exploration permits. The writer takes a critical stance towards the fact that the law has no provisions for taking into account conflicting interests, as well as to why the mineral interest maintains such a strong position as a public interest. Select
Climate change is predicted to lead to an increase in the frequency and severity of climate extremes and variability (IPCC 2007). The result is an increase in climate-related disasters in a world where, even without climate change, the number of disasters is already on the rise (UNISDR 2010). Also Sweden will be severely affected by climate change as temperatures are expected to rise more in North
Uganda, along with a number of other African states, is a state struggling with the task of bringing together a vast range of ethnic minority groups into one nation-state decided by geographical borders drawn by colonial masters Britain during imperialism. The effects of these colonial decisions and policies are widely known to having plagued the native population during the course of history. Thi
Popular Abstract in Swedish 75% av alla kemiska reaktioner sker på en yta av något slag. En av anledningarna till detta är att många ytor har en katalytisk effekt. Inom kemins värld är en katalysator något som påskyndar en kemisk reaktion utan att själv förbrukas, och ett tydligt exempel på en katalytiskt aktiv yta är en bilkatalysator, vilken i princip består av en varm metallyta. På denna yta omThis work deals with interpretation of experimental surface spectroscopic data with the aid of first-principle calculations. Surface infrared reflection-absorption spectra as well as spectra from the electron spectroscopic methods photoemission and X-ray absorption are considered. In all cases the surface is modeled by a metal cluster with the same (frozen) geometry as part of the surface. The wo
