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The human platelet cilostamide- and cGMP-inhibited cAMP phosphodiesterase (cGI-PDE) was rapidly purified approximately 19,000-fold to apparent homogeneity using single step affinity chromatography on the isothiocyanate derivative of cilostamide coupled to aminoethyl agarose. Within 24 h, 30 micrograms of enzyme protein was obtained from 20 ml of packed platelets. Vmax for cAMP and cGMP was 6.1 and
Macrolides have been used for decades as an important chemotherapeutic agent in the treatment of infectious diseases. In the last 10 years there has also been increasing interest in the interaction between macrolide antibiotics and the immune system. The aim of this review is to focus on the anti-inflammatory action of erythromycin and its derivatives in the treatment of chronic sinusitis and nasa
Urban wastewater systems are currently exposed to a major rethink dictated by new demands on resource management. It is postulated that next to providing efficient sanitation (preventing spread of pathogenic microorganisms) these systems should support resource reuse. It remains uncertain of what will be the sanitation of the future; the understanding of technical performances of various alternati
This book, which is the result of my work within the project Conversion and Change of Confession, deals with Catholic mission and conversion in Scandinavia in the 19th and 20th cetries. I focus on Denmark, but the Danish situation is studied in a comparative Nordic pespective and against the background of the general religious, ideological and church-political development at the time. Up to the Se
BACKGROUND: The host response to urinary tract infection includes the production of different inflammatory mediators. We investigated the cellular localization and time course of inducible nitric oxide synthase (iNOS) and cyclooxygenase (COX-2) expression in the mouse bladder and kidney after bacterial infection. METHODS: Experimental urinary tract infection in mice was established by intravesical
In the first century CE, synagogues existed not only in the land of Israel but in all parts of the Roman Empire where Jews lived. Although incorporating a number of activities, the most characteristic features of this institution were the public reading and teaching of torah, making the synagogue an unparalleled institution in the ancient world. But how, when, where, and why did this unique instit
This work reports the morphology of two-phase latex particles prepared by semi-continuous seed emulsion polymerization of styrene in the presence of polar poly(methyl methacrylate), PMMA, seed particles, using different conditions of non-polar styrene feed rate, rate of initiation, seed particle concentration and temperature of polymerization. The expected latex particle morphology at thermodynami
BACKGROUND: Almost every country in the Western world has great difficulties allocating enough financial resources to meet the needs in the care of the increasing elderly population. The main problem is common to all countries and concerns the efforts to meet elderly persons' needs on an individual level while still maintaining society's responsibility for distributing justice. The aim of this stu
Effects of A-322312 (alpha(1B)-adrenoceptor (AR) antagonist), A-119637 (alpha(1D)-AR antagonist), prazosin (non-selective alpha(1)-AR antagonist), and yohimbine (alpha(2)-AR antagonist) were studied in rat corpus cavernosum (CC) and cavernous artery (Acc) preparations. Effects of intracavernous (i.c.) or intraperitoneal (i.p.) administration of alpha(1)-AR antagonists on apomorphine-induced erecti
In chronic lymphocytic leukemia (CLL), the microenvironment influences gene expression patterns; however, knowledge is limited regarding the extent to which methylation changes with time and exposure to specific microenvironments. Using high-resolution 450K arrays, we provide the most comprehensive DNA methylation study of CLL to date, analyzing paired diagnostic/follow-up samples from IGHV-mutate
Popular Abstract in Swedish Införandet av 1993 års skogspolitiska beslut med ett jämställt miljö- och produktionsmål, belyser den historiskt befästa konflikten mellan allmänintresse och egenintresse: statens vilja och behov att styra produktion och avkastning kontra den enskilde skogsägarens rätt att själv bestämma över sin skog. Idag har denna konflikt styrt över mot en statligt uttalad målsättniThis dissertation analyzes the changes in the way Swedish forest policy has been developed and implemented in the past few decades. Its primary focus is on the period from the adoption of new legislation governing forestry in 1993 to date, though the historical antecedents of the more recent developments are also discussed. The dissertation focuses primarily on the interplay between changes in the
The modeling of industrial combustion applications today is almost exclusively based on two-equation turbulence models. Despite its known limitations, the most the widely used model is still the standard k-ε model. The objective of this paper is to investigate the performance of two-equation turbulence models applied to a confined swirling flow. Numerical modeling of an axis-symmetric confined sud
Popular Abstract in Swedish ”Vardagliga problem hos män med prostata cancer. Upplevelser av problem med att kasta vatten, bära kateter och problem i sexuallivet”. Avhandlingens övergripande syfte var att undersöka förekomsten av vardagliga problem hos män med prostatacancer, problemens relation till livskvalitet, till känsla av sammanhang och relationen mellan dessa faktorer, samt att jämföra medThe aim was to investigate the presence of everyday problems in men with prostate cancer, their relation to health-related quality of life, HRQOL, and sense of coherence, SOC, and to compare with men with benign prostatic hyperplasia, BPH, and a sample from the general population. The aim also was to investigate what nursing care needs there were in men with prostate cancer and how these were met
Popular Abstract in Swedish I tider av samhällsförändringar uppträder nya organisationer. De är beroende av att mobilisera resurser från en omgivning som präglas av en gammal ordning. De måste då anpassa sig för att överleva. I denna process är härmandet en central mekanism. Nya organisationer lär sig att överleva genom att härma sin omgivning. Detta leder i sin tur till att de tenderar att bli alNew organizations emerge in times of social change. Their survival depends on their ability to mobilize resources in an environment defined by an old order, and thus they must adapt to it. Since new organizations learn how to adapt by mimicking already succesful organizations, their structure tend to become increasingly similar to the structure of those organizations. The thesis tells the story of
The study concerns whether DNA flow cytometry and estrogen receptor analysis might help predict which breast cancer patients, particularly node-positive ones, were at the greatest risk of developing loco-regional recurrence (LRR). Such patients would best benefit from postoperative radiotherapy following modified radical mastectomy and axillary lymph node dissection. After this type of surgery, 50
Popular Abstract in Swedish Populärvetenskaplig sammanfattning Introduktion Adrenokortikotropiskt hormon (ACTH) stimulerar frisättningen av steroid¬hormoner, främst kortisol, från binjurarna. Kortisol är livsnödvändigt och finns alltid i blodet och förhöjs kraftigt vid stress. I början av 90-talet fann vår forskningsgrupp en koppling mellan ACTH och fettomsättningen som inte involverade steroidhAbstract Adrenocorticotrophic hormone (ACTH) has strong and direct lipid-lowering effects in man. All apoB-containing lipoproteins, i.e. VLDL, LDL, Lp(a), are reduced by 25-30%. In contrast, levels of HDL increase about 10%. In hepatic cell cultures, ACTH inhibits expression and secretion of apoB. In this thesis we corroborate that the reduced apoB synthesis, seen in hepatic cell systems, is als
alpha-Cells were identified in preparations of dispersed mouse islets by immunofluorescence microscopy. A high fraction of alpha-cells correlated with a small cell size measured as the average cell diameter (10 microm) and whole-cell capacitance (<4 pF). The alpha-cells generated action potentials at a low frequency (1 Hz) in the absence of glucose. These action potentials were reversibly inhibite
OBJECTIVE: To form a methodologic basis for DNA analysis of ductal carcinoma in situ (DCIS) and invasive carcinoma (IC) of the breast, including very small lesions, by comparison of flow cytometric (FCM) and image cytometric (ICM) methods for DNA quantitation. STUDY DESIGN: The material consisted of 41 DCIS lesions and 26 ICs. FCM DNA analysis of unfixed, frozen samples were compared to (1) FCM of
To study the effects of elevated ozone concentration on methane dynamics and a sedge species, Eriophorum vaginatum, we exposed peatland microcosms, isolated by coring from an oligotrophic pine fen, to double ambient ozone concentration in an open-air ozone exposure field for four growing seasons. The field consists of eight circular plots of which four were fumigated with elevated ozone concentrat
