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Human activity is constantly causing environmental problems due to production and release of numerous chemicals. A group of compounds of special concern is persistent organic pollutants (POP). These toxic, lipophilic chemicals have a high chemical and biological stability, and tend to accumulate in the lipid phase of living organisms. A major sink for POPs are sediments, and consequently these are
Popular Abstract in Swedish Årligen diagnostiseras cirka 60 000 nya fall av cancer i Sverige (Socialstyrelsen, 2015), och var tredje person beräknas få en cancerdiagnos under sin livstid. Trots stora framsteg inom forskning och utveckling är cancer, näst efter hjärt- och kärlsjukdomar, den vanligaste dödsorsaken i vårt samhälle. Bland de tio vanligaste formerna av cancer hör lymfom, vilket är etMantle cell lymphoma (MCL) is an aggressive form of B-cell lymphoma (BCL) with poor clinical outcome. In this thesis, which is based upon five original papers, different approaches have been used to pinpoint and investigate molecular events that promote MCL tumor growth, progression or resistance to treatment. The aim has been to identify novel targets with the potential to eradicate malignant cel
In 2014, more than 200,000 refugees and migrants fled for safety across the Mediterranean Sea. Crammed into overcrowded, unsafe boats, thousands drowned, prompting the Pope to warn that the sea was becoming a mass graveyard. The early months of 2015 saw no respite. In April alone more than 1,300 people drowned. This led to a large public outcry to increase rescue operations. Throughout this period
AIMS/HYPOTHESIS: Type 1 diabetes in children is characterised by autoimmune destruction of pancreatic beta cells and the presence of certain risk genotypes. In adults the same situation is often referred to as latent autoimmune diabetes in adults (LADA). We tested whether genetic markers associated with type 1 or type 2 diabetes could help to discriminate between autoimmune and non-autoimmune diab
Regeringen ämnar införa synsättet ekonomisk arbetsgivare i Sverige från och med den 1 januari 2021. Förändringen innebär att personer som tidigare kunde åberopa skattefrihet i Sverige till följd av den så kallade 183- dagarsregeln nu i vissa fall blir skattskyldiga i Sverige. Detta gäller arbetstagare som är anställda utomlands men som arbetar i Sverige och anses uthyrda till Sverige. En sådan uthThe Swedish government has proposed introducing the concept of economic employer in Swedish tax law. The changes are proposed to take effect on 1 January 2021 and entail that some individuals, whose income was previously tax exempt due to the so called 183-day rule, now will be subject to Swedish income tax. This applies to situations of hiring-out of labour. A hiring-out of labour situation occur
När en ventilationskanal går igenom en ljudklassad vägg kommer reduktionstalet för skiljekonstruktionen att försämras då ljud kan överföras från det ena till det andra rummet via ventilationskanalen. För att förhindra en försämring av skiljekonstruktionens reduktionstal, vilket är syftet med den här studien, kan flertalet åtgärder tillämpas på kanalen. Tre ljudklassade väggar kombinerades med tre When a ventilation duct passes through a sound-classified wall, the sound reduction index for the combined wall will deteriorate as sound can be transmitted from one room to another via the ventilation duct. In order to prevent a deterioration of the sound reduction index, which is the purpose of the report, several measures can be applied to the duct. Three sound-classified walls are combined wit
Drastic emission-reductions are needed to avoid the disastrous consequences of climate change. Flying is one of the highest individual carbon-impact actions. By 2050, the aviation industry’s share on global greenhouse gas emissions is expected to rise by 300 to 700%. An intervention to counteract this development is to reduce flying at universities as they have a critical role in leading sustainab
En transaktion med en “warehousing”-struktur är en typ av två-stegstransaktion som omfattar flera moment, där säljaren först överlåter målbolaget till en tillfällig köpare som i sin tur överlåter målbolaget till en slutlig köpare. Den tillfälliga köparen används som ett lager för aktierna fram tills den slutliga transaktionen blivit godkänd av Europeiska kommissionen, varefter den slutliga transakA transaction with a warehousing structure is a type of two-step transaction, where the seller first transfers the target company to an interim buyer, who in turn transfers the target company to an ultimate buyer. The interim buyer is used as a ‘warehouse’ for the shares until the ultimate transaction is approved by the European Commission, after which the ultimate transaction can be implemented.
Sharenting är ett relativt nytt fenomen som fått stor medial uppmärksamhet de senaste åren. Vårdnadshavare i form av privatpersoner och influensers tenderar att obetänksamt dela bilder och information om sina barn på nätet utan att tänka på vilka konsekvenser delandet kan leda till. Barns rättigheter har stärkts i allmänhet när FN:s Barnkonvention inkorporerades i svensk lagstiftning år 2020. BarnSharenting is a relatively new phenomenon which has received a great deal of media attention in recent years. Guardians in the form of private individuals and influencers tend to carelessly share photos and information about their children online without thinking about the consequences of sharing. Children's rights have been strengthened in general when the UN Convention on the Rights of the C
Barnhandel är rekrytering, transport, överföring, inhysande eller mottagande av ett barn i syfte att exploatera hen. I Sverige, som i första hand är ett destinationsland för barnhandel, identifieras ett 50-tal barn per år som offer för människohandel. Antalet okända fall uppges dock vara betydligt högre. Med barn re-trafficking avses varje situation där ett barn som har brutit sig loss från en mänChild trafficking is the recruitment, transportation, transfer, harbouring, or receipt of a child for the purpose of exploitation. In Sweden, which primarily is a country of destination for child trafficking, around 50 children per year are identified as child victims of human trafficking. However, the number of unknown cases is said to be significantly higher. Child re-trafficking means any situa
Introduction: Elderly patients often use many drugs, increasing the risk for drug-related problems. Aim: To optimise drug therapy in the elderly by identifying, resolving and preventing drug-related problems. Methods: (Paper I) Medication reviews were conducted on nursing home patients’ with epilepsy or Parkinson’s disease by a multi-speciality team, whom identified drug-related problems and whe
Stroke is a leading cause of death and long-term neurological deficits worldwide, and no effective treatment is available for the vast majority of the stroke patients. A rapid and persistent activation of multiple and dynamic inflammatory and immune cascades, in and outside the brain, occurs after stroke. These cascades are believed to affect the progression of the cerebral damage, as well as neur
The purpose of this thesis is to study the formation of opinions in issues related to the problem area of Christianity and culture of Public Theologian J A Eklund (1863-1945). The concept of Public Theologian refers to a theologian, who by participating in the cultural debate, strives to convince the public that Christianity is a superior theory of life even in modern society, and of Christianity’
The rationale for thrombolysis, the most promising pharmacological approach in acute ischaemic stroke, is centred on the principal cause of most ischaemic strokes: the thrombus that occludes the cerebral artery, and renders part of the brain ischaemic. The occluding thrombus is bound together within fibrin. Fibrinolysis acts by activation of plasminogen to plasmin; plasmin splits fibrinogen and fi
Popular Abstract in Swedish Resenärsinformation utformad för att uppfylla behov och förväntningar hos enskilda resenärer är viktigt för att förbättra resandet i kollektivtrafiken bland äldre personer och personer med funktionsnedsättningar. Det övergripande syftet med den här avhandlingen är att bidra till kunskapen om behov och användning av resenärsinformation bland äldre personer och personer mTraveller information designed to fulfil needs and expectations of individual travellers is a key factor in improving access for older people and people with disabilities to public transport. The overall aim of this thesis is to contribute to the knowledge of user and provider perspectives on the provision of traveller information for older people and people with disabilities in public transport w
Aims. The nature of the thick disc and its relation to the thin disc is presently an important subject of debate. In fact, the structural and chemo-dynamical transition between disc populations can be used as a test of the proposed models of Galactic disc formation and evolution. Methods. We used the atmospheric parameters, [alpha/Fe] abundances, and radial velocities, which were determined from t
During development primary afferents grow into and establish neuronal connections in the spinal cord, conveying information of the anatomical and mechanical properties of the body. This body representation forms the basis for how we perceive sensory information and control our movements. Subsequently, the strength of the sensory input to spinal sensorimotor circuits is functionally adjusted by an
A fundamental problem in robotics is generating the motion for a task. How to translate a task to motion or a series of movements is a non-trivial problem. The complexity of the task, the structure of the robot, and the desired performance determine the sequence of movements, the path, and the course of motion as a function of time, namely the trajectory. As we discuss in this thesis, a trajectory
BACKGROUND: Agriculture consistently ranks as one of the highest risk industries in North America and Europe. In addition to vehicle injuries and other injuries that occur on farms, farm vehicle drivers are also involved in collisions involving tractors and other slow-moving vehicles (SMVs) on public roads. These collisions often lead to injuries among farmers, family members, farm workers, and ot
Popular Abstract in English Huntingtons sjukdom (HS), även kallad danssjukan, är en ärftlig och dödlig sjukdom som leder till ofrivilliga motoriska rörelser. Personer med HS får vanligtvis symtom i medelål- dern och avlider efter 15–20 år. Diagnosen ställs klinisk när de första ofrivilliga rörelserna uppträder. Dessa symtom kan kopplas till celldöd i de delar av hjärna som styr vår rörelse. SjukdoHuntington’s disease (HD) is a neurodegenerative disorder caused by an expansion of the CAG repeat in the huntingtin gene. Non-motor symptoms and signs such as psychiatric disturbances and metabolic dysfunction are also part of the disease manifestation. These symptoms often precede the motor symptoms by decades. The hypothalamus is an area in the brain involved in the regulation of emotions and m
