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Protein S has an established role in the protein C anticoagulant pathway, where it enhances the factor Va (FVa) and factor VIIIa (FVIIIa) inactivating property of activated protein C (APC). Despite its physiological role and clinical importance, the molecular basis of its action is not fully understood. To clarify the mechanism of the protein S interaction with APC, we have constructed and express
Bacterial virulence factors influence the site and severity of urinary tract infections. While pyelonephritis-associated molecular traits have been defined, virulence factors specific for acute cystitis strains have not been identified. This study examined the virulence factor repertoire of 247 Escherichia coli strains, prospectively isolated from women with community-acquired acute cystitis. Fim
The Cd247 gene encodes for a transmembrane protein important for the expression and assembly of TCR/CD3 complex on the surface of T lymphocytes. Down-regulation of CD247 has functional consequences in systemic autoimmunity and has been shown to be associated with Type 1 Diabetes in NOD mouse. In this study, we have utilized the wealth of high-throughput sequencing data produced during the Encyclop
Malignant gliomas (MGs) are the most common malignant primary brain tumors with a short life estimate accompanied by a marked reduction in the quality of life. Herpes Simplex virus-1 thymidine kinase ganciclovir (HSV-TK/GCV) system is the best characterized enzyme prodrug therapy in use. However, lipophobicity of GCV and low enzymatic activity of HSV-TK reduce the treatment efficacy. Tomato TK (To
Tasquinimod, an orally active quinoline-3-carboxamide, binds with high affinity to HDAC4 and S100A9 in cancer and infiltrating host cells within compromised tumor microenvironment inhibiting adaptive survival pathways needed for an angiogenic response. Clinical trials document that as low as 0.5-1mg tasquinimod/day is therapeutic against castrate resistant metastatic prostate cancer. Tasquinimod i
Chromosomal translocations play a crucial role in tumorigenesis, often resulting in the formation of chimeric genes or in gene deregulation through position effects. T-cell acute lymphoblastic leukemia (T-ALL) is associated with a large number of such rearrangements. We report the ectopic expression of the 3' portion of EST DA926692 in the bone marrow of a childhood T-ALL case showing a t(2;11)(q1
Long-term mallard capture-recapture data from Sweden and Finland were analyzed to describe temporal mortality patterns and reasons. We used program MARK and Seber models to estimate annual survival (S) and recovery (r) rates. Survival rates were used in a Monte Carlo simulation to evaluate the correspondence between observed and predicted annual population sizes of a Finnish sub-population. About
Background: The aim of this study was to explore the experiences of patients who suffer from acute cutaneous leishmaniasis in Iran, focusing on quality of life. Methods: The study was conducted at two different sites in Iran in 2010-2011. Individual in-depth interviews were conducted with six men and six women parasitologically confirmed acute cutaneous leishmaniasis. Interviews were recorded, tra
Background: The most concerning complication of video capsule endoscopy (VCE) is capsule retention (CR) in the gastrointestinal (GI) tract although clinical outcome and management of patients with CR are still uncertain in a large single center material. Objectives: The aim of this retrospective study was to investigate incidence, causes, risk factors, management and clinical outcomes of CR in a l
Previous studies on organic sediment contaminants focused mainly on a limited number of highly hydrophobic micropollutants accessible to gas chromatography using nonpolar, aprotic extraction solvents. The development of liquid chromatography–high-resolution mass spectrometry (LC–HRMS) permits the spectrum of analysis to be expanded to a wider range of more polar and ionic compounds present in sedi
Background/Aim: Streptococci cause approximately 10% of prosthetic joint infections (PJIs). The aim of this study was to identify the characteristics of patients with streptococcal PJIs and to describe the treatment and outcome of streptococcal PJIs in Skåne county between 2011 and 2015. Methods: Patients with streptococcal PJIs with positive cultures or PCRs on samples from joint aspirate and/or
Background: Head and neck cancers (HNCs) encompass a heterogeneous group of cancers between the mouth and larynx. Familial clustering in HNCs has been described, but how it influences individual sites and to which extent known risk factors, such as human papilloma virus (HPV) infection, may contribute is not well established. Patients/methods: We employed standardized incidence ratios (SIRs) to es
Objective: To explore whether magnetic resonance imaging (MRI) features suggestive of knee osteoarthritis (OA) are associated with presence of knee pain in possible early-stage OA development. Methods: We included 294 participants from the Osteoarthritis Initiative (mean ± SD age 50 ± 3 years; 50% women) with baseline Kellgren/Lawrence grade of 0 in both knees, all of whom had received knee MRIs a
Moiré superlattices can be used to engineer strongly correlated electronic states in two-dimensional van der Waals heterostructures, as recently demonstrated in the correlated insulating and superconducting states observed in magic-angle twisted-bilayer graphene and ABC trilayer graphene/boron nitride moiré superlattices1–4. Transition metal dichalcogenide moiré heterostructures provide another mo
The Varena Iron Ore deposit in the SW East European Craton is a significant ore body that occurs within metamorphosed and hydrothermally reworked Paleoproterozoic dolostones. We have performed microstructural investigations supplemented with mineral chemistry and geochronological investigations (LA-ICP-MS) to obtain age constraints on the ore-forming event(s) and improve the understanding of the c
We compared outcomes of four different management modalities for diabetic VH. Patients with diabetic VH were identified in this retrospective study undertaken at King Khaled Eye Specialist Hospital, Riyadh, Saudi Arabia. Eyes were grouped based on the treatment received: control (observation only), intravitreal bevacizumab (IVB) injection(s), pars plana vitrectomy (PPV), and preoperative single IV
MILJÖVETENSKAP Preliminärt schema 2019-12-12 Kurs: MVEB15 Miljöpolitik och förvaltning Kursansvarig: Åsa Knaggård Lärare: Elias Isaksson (EI), Åsa Knaggård (ÅK), Erik Persson (EP), Maja Tejre (MT) Lokaler: Litteratur: Carter, Neil (2018). The politics of the environment. Ideas, activism, policy . Tredje upplagan. Cambridge: Cambridge University Press. Dahlström, Carl, red. (2018). Politik som orga
https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/prelt_schema_mveb15_vt2020.pdf - 2026-06-27
Kursguide - Course Syllabus Fastställande Kursplanen är fastställd av Programnämnden för masterutbildningar 2018-01-23 och senast reviderad 2019-02-21. Den reviderade kursplanen gäller från och med 2019- 02-21, vårterminen 2019. Allmänna uppgifter Kursen ges inom ramen för masterprogrammet i medicinsk vetenskap. Undervisningsspråk: Engelska Kursens mål Medicinska fakulteten MEVM07, Medicinsk vet
https://www.lu.se/sites/www.lu.se/files/mevm07_sv.pdf - 2026-06-27
Microsoft Word - Lunds universitets exportkontrollprogram_STYR2020_2073_English_tillg Page 1 of 23 Vice-Chancellor DECISION Reg. No. STYR 2020/2073 Date 2021-10-21 Lund University’s export control programme – compliance programme for dual-use items Approved by the vice-chancellor on 21 October 2021. Postal address Box 117 Visiting address Sandgatan 5 Telephone +46 222 69 29, +46 46 222 00 00 E-mai
Lägg till titel Socialhögskolan Sammanställning av kunnande i förhållande till valideringskriterierna Namn: Personnummer: Ange tydligt vilka av dina förvärvade meriter (formella, icke formella och informella) som du anser motsvarar respektive valideringskriterium. Ett kriterium kan motsvaras av en eller flera typer av meriter, och en merit kan uppfylla flera kriterier. Alla åberopade meriter ska s
https://www.soch.lu.se/sites/soch.lu.se/files/2023-01/Validering%20av%20meriter%20230119.pdf - 2026-06-27
