Filetype
BACKGROUND: Improvements in surgery, imaging, adjuvant treatment, and management of metastatic disease have led to modification of previous approaches regarding the risk of recurrence and prognosis in colorectal cancer. The aims of this study were to map patterns, risk factors, and the possibility of curative treatment of recurrent colorectal cancer in a multimodal setting. METHODS: This was a coh
Avian haemosporidians (Haemosporida) represent a globally distributed, species-rich multiparasite-multihost host-parasite system. Each year, many of these parasite lineages are carried between temperate and tropical regions by migratory birds. While several factors can limit the transmission of avian haemosporidians to new areas, recent studies have shown that some abundant parasites can sometimes
Atmospheric inversions have been used for the past two decades to derive large-scale constraints on the sources and sinks of CO2 into the atmosphere. The development of dense in situ surface observation networks, such as ICOS in Europe, enables in theory inversions at a resolution close to the country scale in Europe. This has led to the development of many regional inversion systems capable of as
Background: The role of insulin resistance as a mediator in the association of body mass index (BMI) with site-specific cancer risk has, to our knowledge, never been systematically quantified. Methods: Altogether 510 471 individuals from six European cohorts, with a mean age of 43.1 years, were included. We used the triglyceride glucose product (TyG index) as a surrogate measure for insulin resist
Background & Aims: Few patients with primary sclerosing cholangitis (PSC) and inflammatory bowel diseases (IBDs) are exposed to tumor necrosis factor (TNF) antagonists because of the often mild symptoms of IBD. We assessed the effects of anti-TNF agents on liver function in patients with PSC and IBD, and their efficacy in treatment of IBD. Methods: We performed a retrospective analysis of 141
Background: Understanding the factors influencing movement is essential to forecasting species persistence in a changing environment. Movement is often studied using mechanistic models, extrapolating short-term observations of individuals to longer-term predictions, but the role of weather variables such as air temperature and solar radiation, key determinants of ectotherm activity, are generally
Objectives: To develop evidence based recommendations for the management of hand osteoarthritis (OA). Methods: The multidisciplinary guideline development group comprised 16 rheumatologists, one physiatrist, one orthopaedic surgeon, two allied health professionals, and one evidence based medicine expert, representing 15 different European countries. Each participant contributed up to 10 propositio
Context: There are limited reliable epidemiological data concerning whether individuals with benign/malignant parathyroid tumor are at an elevated risk of developing nonendocrine malignancies or vice versa. Objective: The objective of the study was to quantify these risks, especially risk of parathyroid tumors after other cancers. Design: This was a population-based retrospective cohort study. Par
ABSTRACT: BACKGROUND: Skeletal uptake of 99mTc labelled methylene diphosphonate (99mTc-MDP) is used for producing images of pathological bone uptake due to its incorporation to the sites of active bone turnover. This study was done to validate bone turnover markers using total skeletal uptake (TSU) of 99mTc-MDP. METHODS: 22 postmenopausal women (52-80 years) volunteered to participate. Scintigraph
The occurrence of floods is expected to increase due to climate change, which may lead to destruction or loss of value of cultural heritage sites. There are approximately 500 church buildings in Lund diocese. The aim of this study was to investigate how this might affect the church buildings, their inventory, and cemeteries within Lund diocese, which are protected under Swedish law. The aim was al
Studier av palaeostormfloder ger bakgrund till inom vilka intevall stormar av olika storlek förväntas återkomma och träffa olika områden. Denna information kan användas vid modellering, riskbedömning och stadsplanering. Genom att använda de marina ekvationerna av Nittrouer och Sternberg (1981; The formation of sedimentary strata in an allochthonous shelf environment: the Washington continental sheStudies of palaeostorm surges provides background into at what frequencies storms of different magnitudes are expected to return and hit different areas. This information can be used when modelling, doing risk assesments and city planing. Using the marine equations of Nittrouer and Sternberg (1981; The formation of sedimentary strata in an allochthonous shelf environment: the Washington continenta
Background: Several biochemical markers in blood correlate with the magnitude of brain injury and may be used to predict neurological outcome after cardiac arrest. We present a protocol for the evaluation of prognostic accuracy of brain injury markers after cardiac arrest. The aim is to define the best predictive marker and to establish clinically useful cut-off levels for routine implementation.
We used an approach that we term ancestry-shift refinement mapping to investigate an association, originally discovered in a GWAS of a Chinese population, between rs2046210[T] and breast cancer susceptibility. The locus is on 6q25.1 in proximity to the C6orf97 and estrogen receptor alpha (ESR1) genes. We identified a panel of SNPs that are correlated with rs2046210 in Chinese, but not necessarily
Background: Due to its high polymorphism and importance for disease resistance, the major histocompatibility complex (MHC) has been an important focus of many vertebrate genome projects. Avian MHC organization is of particular interest because the chicken Gallus gallus, the avian species with the best characterized MHC, possesses a highly streamlined minimal essential MHC, which is linked to resis
Abstract in UndeterminedThe aim of this study was to evaluate the extent to which water use efficiency (WUE) at leaf scale can be used to assess WUE at canopy scale, leaf WUE being assumed to be a constant function of vapor pressure deficit and to thus not be dependent upon other environmental factors or varying leaf properties. Leaf WUE and its variability and dependencies were assessed using lea
Rationale and Objectives: To compare the ability of normalized versus non-normalized metabolite ratios to differentiate recurrent brain tumor from radiation injury using magnetic resonance spectroscopy (MRS) in previously treated patients. Materials and Methods: Twenty-five patients with previous diagnosis of primary intracranial neoplasm confirmed with biopsy/resection, previously treated with ra
This report presents how far NCC current VDC tools and methods in building construction can be implemented in road and infrastructure projects also what new tools, methods that can be created helped by pre-selected software’s. VDC is well developed within the construction of building and research and resources in the field have been spent under a longer period of time unlike in road and infrastruc
Tidigare studier har dokumenterat ett flertal fossila meteoriter samt höga koncentrationer av utomjordisk kromit (ett järn-kromoxidmineral) i cirka 467 miljoner år gamla, mellanordoviciska sedimentlager. Fynden antas vara resultaten av ett tillfälligt förhöjt inflöde av meteoritiskt material, efter uppbrytningen av en kropp i asteroidbältet – de så kallade L-kondriternas föräldrakropp – för omkriNumerous fossil meteorites and high concentrations of sediment-dispersed extraterrestrial chromite (EC) grains with typical ordinary chondritic composition have previously been documented from 467±1.6 Ma Ma lower Kundan (Middle Ordovician) strata. These finds most likely reflect a temporarily enhanced influx of ordinary chon- dritic matter, following the disruption of the L chondrite parent body i
In the present time, the rate of environmental degradation requires us to use all available means to avoid further damage and restore the environment to the best of our possibilities. Education is an important channel to promote environmentalism and sustainability, and to promote pro-environmental individual decisions, especially regarding consumption and purchasing patterns. The case study analys
BACKGROUND Embolic strokes of undetermined source represent 20% of ischemic strokes and are associated with a high rate of recurrence. Anticoagulant treatment with rivaroxaban, an oral factor Xa inhibitor, may result in a lower risk of recurrent stroke than aspirin. METHODS We compared the efficacy and safety of rivaroxaban (at a daily dose of 15 mg) with aspirin (at a daily dose of 100 mg) for th
