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BACKGROUND: Genetic association studies have reported single-nucleotide polymorphisms (SNPs) at chromosome 19q13.3 to be associated with prostate cancer (PCa) risk. Recently, the rs61752561 SNP (Asp84Asn substitution) in exon 3 of the kallikrein-related peptidase 3 (KLK3) gene encoding prostate-specific antigen (PSA) was reported to be strongly associated with PCa risk (P 2.3 108). However, the bi
Galectin-3 is an adhesion/growth-regulatory protein with a modular design comprising an N-terminal tail (NT, residues 1-111) and the conserved carbohydrate recognition domain (CRD, residues 112-250). The chimera-type galectin interacts with both glycan and peptide motifs. Complete (13)C/(15)N-assignment of the human protein makes NMR-based analysis of its structure beyond the CRD possible. Using t
The high-molecular-mass salivary mucin MG1, one of two major mucins produced by human salivary glands, plays an important role in oral health by coating the tooth surface and by acting as a bacterial receptor. Here this mucin was purified from the submandibular/sublingual saliva of a blood group O individual. The presence of MUC5B as the major mucin in this preparation was confirmed by amino acid
Active surveillance of invasive group A streptococcal (GAS) infections was conducted in Denmark during 2003 and 2004 as a part of the Strep-EURO initiative. The main objective was to improve understanding of the epidemiology of invasive GAS disease in Denmark. During the 2 years, 278 cases were reported, corresponding to a mean annual incidence of 2.6 cases per 100,000 inhabitants. The vast majori
Objective: To evaluate the results of the expanded National Venous Screening Program (NVSP) as administered by the American Venous Forum. Methods. Eighty-three physicians across 40 states participated in screening Americans for venous disease. The NVSP instrument included demographics, venous thromboembolism (VTE) risk assessment, quality-of-life (QOL) assessment, duplex ultrasound scan for reflux
Environmental and process control applications have needs for sensors that operate continuously or repeatedly, making them applicable to batch measurement and flowing product stream measurement. Additionally, for lactose monitoring in dairy-processing plants, the sensors must have sufficient flexibility to handle a wide range of substrate concentration and be resilient to withstand wide pH excursi
During development, information about the three-dimensional shape and mechanical properties of the body is laid down in the synaptic connectivity of sensorimotor systems through adaptive mechanisms. This functional adaptation occurs through alteration of connection properties. Here, we characterize the differences between strong and weak connections in the nociceptive withdrawal reflex in adult de
The role of endothelium-derived nitric oxide in the regulation of vascular resistance (tonus) in cat skeletal muscle was studied with the use of NG-monomethyl-L-arginine (L-NMMA), a specific inhibitor of nitric oxide formation from L-arginine. The study was performed with a whole-organ technique which permits simultaneous, continuous and quantitative recordings of resistance reactions in the whole
Background. NT-proBNP may be useful for ruling out heart failure in primary health care. In this study we examined the analytical quality of NT-proBNP in primary health care on the Cobas h 232 point-of-care instrument compared with measurements performed in a hospital laboratory. Materials and methods. Blood samples requested for NT-proBNP were collected in primary health care (n = 95) and in a ho
Retinitis pigmentosa (RP) defines a group of inherited degenerative retinal diseases causing progressive loss of photoreceptors. To this day, RP is still untreatable and rational treatment development will require a thorough understanding of the underlying cell death mechanisms. Methylation of the DNA base cytosine by DNA methyltransferases (DNMTs) is an important epigenetic factor regulating gene
Background and Aims: Little is known about small-bowel (SB) capsule endoscopy (CE) in patients with a history of gastric surgery. This study aims to evaluate the feasibility and diagnostic yield (DY) of orally ingested SB-CE in patients with surgically altered gastric anatomy. Methods: Twenty-four European centers retrospectively identified patients who had SB-CE after total or subtotal gastrectom
Objective: Characterise the spatiotemporal trabecular and cortical bone responses to complete spinal cord injury (SCI) in young rats. Methods: 8-week-old male Wistar rats received T9-transection SCI and were euthanised 2-, 6-, 10-or 16-weeks post-surgery. Outcome measures were assessed using micro-computed tomography, mechanical testing, serum markers and Fourier-transform infrared spectroscopy. R
There is emerging evidence of an association between epigenetic modifications, glycemic control and atherosclerosis risk. In this study, we mapped genome-wide epigenetic changes in patients with type 2 diabetes (T2D) and advanced atherosclerotic disease. We performed chromatin immunoprecipitation sequencing (ChIP-seq) using a histone 3 lysine 9 acetylation (H3K9ac) mark in peripheral blood mononuc
The aim of this study is to generate a quality-controlled sub-kilometer dataset of the fraction of absorbed photosynthetically active radiation (FAPAR) across Scandinavia from satellite. FAPAR is required for estimating the amount of PAR absorbed (APAR) by vegetation, which in turn allows for estimation of carbon uptake. In this study, FA-PAR was modeled from normalized difference vegetation index
Title: Synergi, a digital reporting tool for working environment. Authors: Sebastian Larsson & Joel Ståhl Supervisor: Radhlinah Aulin, Senior lecturer at the Department of Building and Environmental Technology, Division of Construction Management, Lund University. Examinator: Anne Landin, Professor at the Department of Building and Environmental Technology, Division of Construction Management,
The Swedish housing market faces a number of concerns. There are too few rental units with cheap rent available and the capital input to buy your own freehold title or tenant-ownership is skyrocketing. The threshold for entering the housing market is getting higher and groups such as young adults, new arrivals, disabled people, and the elderly are the ones who are the most exposed. Developers get
Urban green infrastructure (UGI) is gaining popularity for disaster risk reduction and climate change adaptation in urban contexts, but dense development obstructs the realisation of large-scale greening measures. This thesis investigates the potential of small-scale, site-specific urban greening in a residential area in Cologne, Germany, to improve ecosystem service supply. The objective is to as
This thesis examined the impact of the COVID-19 lockdown on Athenian air quality from March 23rd to May 5th, 2020. The Attica Ground Measuring Network was used to measure the concentrations of NO, NO₂, SO₂, CO, PM₁₀, PM₂.₅, and O₃ for the 2020 lockdown and for the same time period from 2005 to 2019 as reference. Nitric oxide (NO) and nitrogen dioxide (NO₂) concentrations decreased by up to 75% an
Internships and/or thesis projects at SEI?Since January 2017 Lund University and Stockholm Environment Institute (www.sei-international.org) has a cooperation agreement. Through this agreement, SEI invites LU students to apply for internships and/or propose thesis projects. If interested, please have a look at SEI’s research areas and prepare a thesis idea or expression of interest for internship.
https://www.cec.lu.se/sv/utbildning/grund-och-avancerad-utbildning/nyheter - 2026-07-05
Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study Biomarker discovery study design for type 1 diabetes in The Environmental Determinants of Diabetes in the Young (TEDDY) study Hye-Seung Lee1 Brant R. Burkhardt2 Wendy McLeod1 Susan Smith1 Chris Eberhard1 Kristian Lynch1 David Hadley1 Marian Rewers3 Olli Simell4 Jin-Xiong Sh
https://www.teddy.lu.se/sites/teddy.lu.se/files/2021-11/33%2006032016_679_33_Lee_DMRR_2013.pdf - 2026-07-05
