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Background: Poorly differentiated midline carcinoma with a translocation between chromosomes 15 and 19, i.e. t(15; 19), has been recognized as a distinct clinical entity for over a decade. This tumor affects young individuals, shows a rapidly fatal clinical course despite intensive therapy. The t( 15; 19) results in the fusion oncogene BRD4-NUT. Information concerning treatment of this rare disord

Lack of oxygen delivery to the cells results in excessive production of oxygen free radicals in the cells leading to a pathological condition postulated as hypoxia. One of the most crucial transcription factors that can adapt to the fluctuating levels of hypoxia is Hypoxia Inducible Factor-1α (HIF-1α). Chronic obstructive pulmonary disease (COPD) is amongst the common lung diseases majorly caused

BACKGROUND: In response to the Institute of Medicine (IOM) report, Dying in America, we undertook an institution wide effort to improve the experience of patients and families facing serious illness by engaging leadership and developing a program to promote the practice of generalist palliative care.MEASURES: The impact of the program was measured with process measures related to its' three parts.

1. We studied the resting metabolic rate (MR) from two great tit Parus major (Linnaeus) populations living in different winter regimes. Birds from the two different localities were exposed individually to +25 °C, 0 °C and −10 °C for the night in three consecutive sessions in random order. 2. Birds from Lund (Sweden) had a lower basal MR, as measured at thermoneutrality (+25 °C), than had birds f

Two different commercial polymeric materials, a silicone and a polyurethane (PUR), were studied with regard to correlations between the chemical and physical compositions of the polymer surfaces and the biological response on implantation. Test specimens of the materials were manufactured according to standard procedures. The specimens were implanted in rats for 10 and 90 days. Before implantation

The groin field built at Westhampton, Long Island, NY, in the 1960s and early 1970s has functioned as intended in protecting a once-vulnerable 4.8-km long segment of barrier beach that had experienced repeated breaching. In 1996-1997, a tapered groin transition to the west was created. The tapering included placement of fill in the existing groin compartments and on the adjacent beach. The combine

Statins effectively lower LDL cholesterol levels in large studies and the observed interindividual response variability may be partially explained by genetic variation. Here we perform a pharmacogenetic meta-analysis of genome-wide association studies (GWAS) in studies addressing the LDL cholesterol response to statins, including up to 18,596 statin-treated subjects. We validate the most promising

Wind and ocean currents may potentially have important effects on travelling animals, as an animal which does not respond to lateral flow will be drifted from its intended direction of movement. By analysing daily movements of migrating ospreys Pandion haliaetus and marsh harriers Circus aeruginosus, as recorded by satellite telemetry, in relation to global wind data, we showed that these raptors

Forest soil carbon (C) pools may act as sinks for, or sources of, atmospheric carbon dioxide, while nitrogen (N) fertilization may affect the net exchange of C in forest ecosystems. Since all major C and N processes in soil are driven by soil microorganisms, we evaluated the effects of N fertilization on biomass and bacterial and fungal activity in soils from three Norway spruce forests with diffe

Auoxo3 is a gold(iii) compound endowed with cytotoxic activity towards a variety of malignant cells. Encapsulation of Auoxo3 within horse spleen ferritin (Ft) improves the selectivity of the gold compound towards cancer cells over normal cells. In the current work, the changes in protein expression are presented in response to MCF-7 stimulation with Auoxo3-encapsulated Ft versus the free Au(iii) c

Following centuries of deforestation, many industrialized countries have experienced an increase in forest area and biomass due to changes in land- and forest-use since the mid-20th century. At the same time, the impacts of climate change on forests are aggravating, but the interplay between past land- and forest-use (i.e. land- and forest-use legacies) and climate change in tree growth remains el

Abstract: The main player of this thesis is glucose, both on a cellular level and with a clinical approach. Too much or wrongly handled glucose contributes to increased inflammation and oxidative stress, which is reinforced by the negative influences of uraemia and dialysis treatment. In addition, trace element status is also affected in dialysis patients. Hyperglycaemia contributes to glucose deg

Background: Activities of daily living (ADL) are an essential part of the diagnostic criteria for Alzheimer's disease (AD). A decline in ADL affects independent living and has a strong negative impact on caregiver burden. Functional response to cholinesterase inhibitor (ChEI) treatment and factors that might influence this response in naturalistic AD patients need investigating. The aim of this st

Objective: To discover a possible absorption and/or secretion of enterostatin into the circulating blood, as well as to compare the levels of circulating enterostatin after high-fat feeding and low-fat feeding. Research Methods and Procedures: Using a specific enzyme-linked immunosorbent assay, plasma enterostatin levels were determined after feeding a high-fat, a high-fat/sucrose, or a low-fat me

Experiments were done to examine the phototrophic response of sun-tracking leaves of Lupinus succulentus Dougl. to fixed beams of white and broad band light. Upon irradiation with 15 W m-2 white light that struck the laminae at an angle of 45°, there was a 45–60 min lag period prior to leaf movement. The greatest rate of movement was 15° h-1, and reorientation ceased when leaves attained a positio