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Background: The SYNAPSE study (NCT03085797) demonstrated that mepolizumab decreased nasal polyp (NP) size and nasal obstruction in patients with chronic rhinosinusitis with NP (CRSwNP). Methods: SYNAPSE, a randomized, double-blind study, included patients with recurrent, refractory, severe CRSwNP, eligible for repeated surgery despite receiving standard of care (SoC). Patients received 4-weekly me
Effective tax systems play a key role in self-sustained economic growth. Where foreign aid can provide much needed funds for less developed countries, it may also increase aid dependency if the country does not simultaneously improve its taxing capacity. This thesis is empirically investigating the relationship of foreign aid and tax revenue mobilization in a panel of 53 African countries during 1
Predictors for the pharmacological effect of ADHD medication in children and adolescents are lacking. This study examined clinically relevant factors in a large (N = 638) prospective cohort reflecting real-world evidence. Children and adolescents aged 6–17 diagnosed with ADHD were evaluated at baseline and three months following ADHD medication initiation. The outcome was measured as a reduction i
Honig and Samuelsson (2014) recently published an article in this outlet criticizing “Does business planning facilitate the development of new ventures? “ a paper I wrote with Scott Shane nearly 15 years ago. They claim that their effort adds to the discussion of (a) the merits of business planning, (b) data replication and extension, (c) sample selection bias, (d) evaluation of normative research
Malaria parasites are highly virulent pathogens which infect a wide range of vertebrates. Despite their importance, the way different hosts control and suppress malaria infections remains poorly understood. With recent developments in next generation sequencing techniques, however, it is now possible to quantify the response of the entire transcriptome to infections. We experimentally infected Eur
In patients on peritoneal dialysis (PD) ultrafiltration failure (UFF) often develops after 3 or 4 years of treatment. Increased angiogenesis, leading to an increase in small solute transport, is a key feature of UFF. Among the pathophysiological mechanisms responsible for an increased angiogenesis, peritonitis, or just 'low-grade inflammation', such as in the uremic condition per se seem to be of
