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Amyotrophic lateral sclerosis (ALS) is a neurodegenerative disease characterized by a progressive loss of motor neurons. Neuroinflammation is apparent in affected tissues, including increased T cell infiltration and activation of microglia, particularly in the spinal cord1,2. Autoimmune responses are thought to have a key role in ALS pathology, and it is hypothesized that T cells contribute to the
GABA is the main inhibitory neurotransmitter in the mammalian CNS. GABA in the brain is commonly associated with a fast, point-to-point form of signalling called synaptic transmission (phasic inhibition), but there is growing evidence that GABA participates in another, slower and more diffuse form of signalling often referred to as tonic inhibition. Unresolved questions regarding tonic neuronal in
Studies report that urticarial dermographism is exacerbated by "life events" and emotions. The aim of this study was to determine what aspects of life quality are affected by symptomatic dermographism and whether acute stress is a potential triggering factor. A total of 21 adult patients with urticarial dermographism completed a questionnaire on symptoms and quality of life. Twelve patients agreed
Popular Abstract in Swedish Kroppens svar på vävnadsskada är avgörande för initierandet av läknings-processen och försvaret mot invaderande mikroorganismer. Det lokala samspelet mellan de olika cellerna i immunförsvaret sker genom cellsignalering via små proteiner kallade cytokiner. Ett kraftigt eller obalanserat svar kan medföra att inflammationsdrivande cytokiner (IL-6, IL-1, TNF) läcker ut i blCell-signalling via cytokines modulates the local response to surgical trauma, directs the immunologic response and initiates the healing process. Surgical trauma induces a systemic cytokine response and a down-regulation of the antigen presentation capacity of monocytes (HLA-DR expression), which is associated with a poor prognosis if pronounced. The aims with the studies in this thesis were to i
As Cooren and Sandler note in their paper, communication studies has largely received Bakhtin as a theorist of dialogue, but such a framing limits his potential contributions to our thinking. They argue that when we seek to understand the communicative constitution of reality, Bakhtin's work can lead us in novel and fruitful directions. I find their claims compelling, and thus this response is mor
Background: A varying response to cholinesterase inhibitor (ChEI) treatment has been reported among patients with Alzheimer's disease (AD). Whether the individual-specific response, specific ChEI agent or dose affects mortality is unclear. We aimed to examine the relationship between the 6-month response to ChEI and lifespan. Methods: Six hundred and eighty-one deceased patients with a clinical AD
Rewetting a dry soil can result in two response patterns of bacterial growth and respiration. In type 1, bacterial growth starts to increase linearly immediately upon rewetting and respiration rates are highest immediately upon rewetting. In type 2, bacterial growth starts to increase exponentially after a lag period with a secondary increase in respiration occurring at the start of the exponentia
The paper is aimed at the description of the newly introduced model used to simulate the neural response to the chemical stimulus. A potential difference across the living cell or tissue depends usually on the chemical excitation of this living entity. The peculiar case of chemical excitation is the odour recognition across animal kingdom, in particular by various insects. A potential difference i
Purpose: The aim of this paper is to describe, analyze and explain the level of compliance of accounting practices with legislation and generally accepted accounting principles (GAAP) within the Swedish water and sewerage sector. Design/methodology/approach: The empirical data are based on a document study of the annual full cost accounting reports for the financial year 2010. Weobtained complete
Urinary tract infections activate a mucosal inflammatory response, which includes cytokine secretion and neutrophil influx. The mechanisms involved in the neutrophil influx have not been identified. Interleukin-8, a potent chemoattractant for neutrophils, is produced by urinary tract epithelial cell lines in vitro. This study analyzed the human IL-8 response to deliberate Escherichia coli infectio
Crustacean copepods in high-latitude lakes frequently alter their pigmentation facultatively to defend themselves against prevailing threats, such as solar ultraviolet radiation (UVR) and visually oriented predators. Strong seasonality in those environments promotes phenotypic plasticity. To date, no one has investigated whether low-latitude copepods, experiencing continuous stress from UVR and pr
The aging lung is increasingly susceptible to infectious disease. Changes in pulmonary physiology and function are common in older populations, and in those older than 60 years, pneumonia is the major cause of infectious death. Understanding age-related changes in the innate and adaptive immune systems, and how they affect both pulmonary and systemic responses to pulmonary challenge are critical t
Many pathogenic bacteria have been reported to interact with human platelets to mediate platelet activation and aggregation. The importance of these interactions to the immune response or pathogenesis of bacterial infection has not been clarified. It may therefore be valuable to assess platelet responses mediated by diverse strains of bacteria. Here, I describe a method to study platelet integrin
1. A 6-year study (1992-97) of changes in submerged vegetation after biomanipulation was carried out in the eutrophicated Lake Finjasjon, Southern Sweden. Ten sites around the lake were revisited each year. At each site five samples of above-ground biomass were taken at 10 cm water depth intervals. An investigation of the seed bank at the 10 sites, and a grazing experiment where birds and large fi
