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Fairy tales have long captivated audiences with their timeless narratives and symbolic depth. Inspired by these stories, this thesis explores how the abstract concepts embedded within fairy tales can be translated into tangible, functional designs. While constructing a narrative may seem straightforward, the real challenge lies in transforming these intangible ideas into physical objects that not
The Open and Reproducible Musculoskeletal Imaging Research community is a scientific community dedicated to promoting openness and reproducibility in musculoskeletal imaging, image processing, and computational modeling. In this perspective paper, we outline the motivations for conducting transparent research and provide practical guidelines for implementing it. We start by defining open and repro
Objective: Anaemia in low-risk MDS is associated with reduced quality of life (QoL). Response to treatment with erythropoietin (EPO) + G-CSF is associated with improved QoL, but whether transfusion therapy with higher haemoglobin (Hb) target levels has similar effects is unknown. The objective for this prospective phase II Nordic multicentre trial was to assess QoL, response rate and physical func
Single-tricot warp-knitted structures made from polyester-fibre (PET-fibre) yarns are analysed for their geometrical properties and their uniaxial tensile behaviour. A detailed study is devoted to the inter-yarn friction in these structures, since yarn slippage is one of the effects dominating large-scale deformations of the fabrics. Both static (initiation of slippage) and sliding (ongoing slippa
Differences between the recombinant xylose-utilizing Saccharomyces cerevisiae strain TMB 3399 and the mutant strain TMB 3400, derived from TMB 3399 and displaying improved ability to utilize xylose, were investigated by using genome-wide expression analysis, physiological characterization, and biochemical assays. Samples for analysis were withdrawn from chemostat cultures. The characteristics of S
Mass balance pharmacokinetics, with simultaneous blood sampling from an artery and the internal jugular vein, was used to characterize the cerebral uptake of ketamine, norketamine, and midazolam in normoventilated pigs. Intravenous injections of ketamine or midazolam decreased the cerebral blood flow (CBF) by one third, as measured by intermittent 133Xe washout. By means of pharmacodynamic models,
The plasminogen activating system is involved in tumor growth and metastasis by degradation of extracellular matrix, and modulation of cell adhesion and migration. Benign and well-differentiated malignant ovarian tumors present as cystic lesions with preserved glandular morphology, whereas poorly differentiated tumors and metastases are solid with characteristic absence of glandular morphology. We
Chronic obstructive pulmonary disease is a major cause of increased morbidity and mortality. The aim of this study was to investigate hospital admission rates among individuals with symptoms of chronic bronchitis and among those with airflow limitation corresponding to GOLD stages 1-4. Method: Between 1974 and 1992, 22 044 middle-aged individuals participated in a health screening, which included
Popular Abstract in Swedish Patienter som drabbats av Parkinsons sjukdom (PD) saknar förmågan att medvetet kontrollera sina rörelser. Livslång medicinering krävs, vilket lindrar symptomen och leder till att rörelsemönstret förbättras, men med varierad effektivitet. Trots att de läkemedel (t ex L-DOPA) som finns tillgängliga idag har fantastisk effekt, minskar deras effektivitet i takt med att sjukParkinson’s disease (PD) is a neurodegenerative disorder characterised by motor deficits such as slowness in movement, difficulty in initiating movement and tremor at rest. The cause of these motor symptoms is the selective loss of mesencephalic dopaminergic (mesDA) neurons, located in the substantia nigra (SN). These neurons project axons to the striatum where they release dopamine, a neurotransm
We present a model for developing health services for men who have sex with men (MSM) in sub-Saharan Africa and other places where MSM are heavily stigmatized and marginalized. The processes of the SPEND model include Safe treatment for sexually transmissible infections (STIs) and HIV; Pharmacy sites for treatment of STIs in countries where pharmacies and drug stores are the source of medical advi
Popular Abstract in English This study concerns the city of Damascus in the Syrian Arab Republic. Damascus is a city where the current urban form is characterized by wide streets and lack of shade as well as limited amount of green areas, which negatively affect the microclimate and thermal comfort. This study is mainly focused on residential streets and how the urban planning regulations affect tThis research is an attempt to develop further understanding of the relationship between microclimate, thermal comfort, urban design and outdoor space users in the hot dry city of Damascus. This is done by studying the impact of urban regulations on microclimate in different urban design patterns in Damascus. This study also aims to investigate the behaviour of different thermal comfort indices an
OBJECTIVE-Recent advances in type 2 diabetes genetics have culminated in the discovery and confirmation of multiple risk variants. Two important, and largely unanswered questions are whether this information can be used to identify individuals most susceptible to the adverse consequences of sedentary behavior and to predict their response to lifestyle intervention; such evidence Would be mechanist
Background: Recruitment is one of the most serious challenges in performing randomized controlled trials. Often clinical trials with participants diagnosed with schizophrenia are terminated prematurely because of recruitment challenges resulting in a considerable waste of resources in the form of time, funding, and the participants' efforts. Dropout rates in schizophrenia trials are also high. Rec
If we find life on another world, it will be an extremely important discovery and we will have to take great care not to do anything that might endanger that life. If the life we find is sentient we will have moral obligations to that life. Whether it is sentient or not, we have a duty to ourselves to preserve it as a study object, and also because it would be commonly seen as valuable in its own If we find life on another world, it will be an extremely important discovery and we will have to take great care not to do anything that might endanger that life. If the life we find is sentient we will have moral obligations to that life. Whether it is sentient or not, we have a duty to ourselves to preserve it as a study object, and also because it would be commonly seen as valuable in its own
Bakgrund: Hur vi identifierar oss är starkt kopplat till arbete. Unga vuxna är en känslig grupp när det gäller inträde på arbetsmarknaden. Om de också har psykisk ohälsa blir det ännu svårare och risken för marginalisering ökar. Likväl har arbete visat väsentlig betydelse för en personlig återhämtning. Syftet med studien var att utforska erfarenheter bland unga vuxna med psykisk ohälsa som börjar
Theoretical calculations of reaction kinetics were done for one‐step reactions catalyzed by cells immobilized in spherical beads. The reactions catalyzed by free cells were assumed to obey Michaelis–Menten kinetics for a one‐substrate reaction. Both external (outside the beads) and internal (inside the beads) mass transfer of the substrate were considered for the immobilized preparations. The theo
A combined experimental/numerical method for determination of constitutive parameters in high strain-rate material models is presented. Impact loading, using moderate projectile velocities in combination with small specimens (sub mm) facilitate tensional strain rates in the order of 10(4)-10(5) s(-1). Loading force is measured from one-dimensional wave propagation in a rod using strain gauges and A combined experimental/numerical method for determination of constitutive parameters in high strain-rate material models is presented. Impact loading, using moderate projectile velocities in combination with small specimens (sub mm) facilitate tensional strain rates in the order of 104–105 s−1. Loading force is measured from one-dimensional wave propagation in a rod using strain gauges and deform
