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Assessment of health-related quality of life (HRQoL) in haemophilia is important in order to provide information for clinical decision making and to verify the impact of haemophilia on patients and their families. Advances in haemophilia care and prophylactic treatment have improved HRQoL for the patients and where treatment is available, patients with haemophilia have almost reached the same life
Popular Abstract in Swedish Övergripande syfte Syftet med avhandlingen var att utvärdera hur en förenklad metod för diagnostisering av blodproppar i benets djupa ådror (djup ventrombos (DVT)) fungerar i svensk rutinsjukvård. Den förenklade metoden innebär användning av en strukturerad klinisk sannolikhetsbedömning tillsammans med ett blodprov (D-dimer test). Vi jämförde också vår D-dimermetod med The combination of pre-test clinical probability assessment and D-dimer test is now widely applied in the diagnostic process of DVT. The general objective of the present investigation was to validate these results in a Swedish routine emergency setting were the prevalence of the disease is high and were the clinical probability assessment was handled by many junior physicians. Furthermore, our aim
Alpha-synuclein (SNCA) protein aggregation plays a causal role in Parkinson's disease (PD). The SNCA protein modulates neurotransmission via the SNAP receptor (SNARE) complex assembly and presynaptic vesicle trafficking. The striatal presynaptic dopamine deficit is alleviated by treatment with levodopa (l-DOPA), but postsynaptic plastic changes induced by this treatment lead to a development of in
Atmospheric aerosol particles serving as cloud condensation nuclei (CCN) are key elements of the hydrological cycle and climate. We have measured and characterized CCN at water vapor supersaturations in the range of S=0.10-0.82% in pristine tropical rainforest air during the AMAZE-08 campaign in central Amazonia. The effective hygroscopicity parameters describing the influence of chemical composit
Popular Abstract in Swedish SAMMANFATTNING PÅ SVENSKA (Swedish summary) Ultraljud används sedan 1970-talet rutinmässigt under graviditet. Undersökningen görs vanligen vid 17-18 graviditetsveckor och syftet med undersökningen är att datera graviditeten dvs bestämma tiden för beräknad förlossning. Man upptäcker också eventuella tvillingar vid denna undersökning. Redan tidigt visade det sig att visWe studied the prenatal detection rate of various malformations during a study period of 16 years in a population in southern Sweden consisting of 141 240 deliveries. The overall detection rate was 28.4% and the false positive diagnoses were very few. We studied the effect of prenatal diagnosis on the rate of spina bifida in southern Sweden compared with the rest of the country and could show tha
Uppsatsens syfte är att undersöka och diskutera om the Draft Common Frame of Reference (DCFR) är en rättskälla i svensk rätt. Detta görs genom att redogöra för argument för och emot referensramen som svensk rättskälla. Denna fråga är viktig att utreda då det finns skilda meningar om detta bland den svenska juridiska doktrinen. Detta skapar ett osäkert rättsläge som kan ge upphov till osäkerhet infThis thesis deals with the question of whether or not the Draft Common Frame of Reference (DCFR) is a source of law in the Swedish legal system. This is done by outlining the arguments for and against the frame of reference as a Swedish law source. This issue is important to investigate because of the disagreement among the swedish judical experts whether it is or not. This legal uncertainty creat
Titel: Strategier för relationskommunikation via sociala medier Författare: Eric Malmquist Handledare: Jörgen Eksell Nyckelord: Marknadsföring (relationsmarknadsföring, industriell marknadsföring), sociala medier, B2B, kommunikation (strategisk kommunikation, marknadskommunikation, relationskommunikation), meningsskapande, dialog och konsumentbeteende Problem: Problemet och kunskapsluckan som jTitle: Operational strategies for relationship communication in social media Author: Eric Malmquist Advisor: Jörgen Eksell Keywords: Marketing (Industrial marketing, relationship marketing), Communication (strategic communication, marketing communication, relationship communication), B2B, Social media, Meaning creation, Dialogue and Consumer behaviour. Problem: There are very few studies regard
Uppsatsens fokus ligger på att undersöka effekterna av det 21 december 2012 ikraftträdda förbudet mot könsdifferentierade försäkringspremier och –ersättningar. Förbudet har sin bakgrund i ett mål i EU-domstolen, där domstolen kom att ogiltigförklara en undantagsregel som gav medlemsstaterna möjlighet att på obestämd tid tillåta användandet av kön som faktor vid försäkringsföretagens beräknande av The main purpose of this thesis is to evaluate and analyze the impact of the prohibition against the use of sex as a factor in the calculation of premiums and benefits for the purpose of insurance services that entered into force 21 December 2012. The prohibition is a result of a judgment by the European Court of Justice declaring that the exception in Directive 2004/113/EC, giving member states t
Framställningen utgår från frågeställningen under vilka omständigheter ett felaktigt stämmobeslut blir gällande, och därmed verkställbart av styrelsen. Med felaktiga stämmobeslut avses i denna uppsats sådana beslut som kan angripas av aktieägarna i enlighet med 7 kap. 50 och 51 §§ ABL. Dessa är beslut som innehåller ett formellt eller materiellt fel p.g.a. att de strider mot någon regel i ABL, bolThis essay is based on the question under which circumstances an erroneous resolution from the general meeting (hereinafter referred to as “resolution”) shall take effect and thus become enforceable by the board of directors. For the purpose of this essay, erroneous resolutions shall mean such resolutions that may be challenged by the shareholders pursuant to chapter 7 sections 50 and 51 in the Co
Context Small single-center studies have shown that cerebrospinal fluid (CSF) biomarkers may be useful to identify incipient Alzheimer disease (AD) in patients with mild cognitive impairment (MCI), but large-scale multicenter studies have not been conducted. Objective To determine the diagnostic accuracy of CSF beta-amyloid(1-42) (A beta 42), total tau protein (T-tau), and tau phosphorylated at po
Artikel 6 i Europakonventionen för de mänskliga rättigheterna stadgar en rätt till en rättvis rättegång. Ett av de många drag som utmärker en rättvis rättegång är likställdhet mellan parterna. I denna uppsats undersöks innebörden av principen om parternas likställdhet och huruvida den svenska brottmålsprocessen tillgodoser de rättigheter som uppställs i Europa-konventionen. Principen om parternaAccording to article 6 of the European Convention on Human Rights, everyone charged with a criminal offence is entitled to a fair hearing. One of the many features characteristic of a fair hearing is equality of arms between the parties. In this essay, the meaning of the principle of equality of arms is analysed. It is also investigated if the Swedish criminal procedure is in conformity with the p
Identification of prostate gold fiducial markers in magnetic resonance imaging (MRI) images is challenging when CT images are not available, due to misclassifications from intra-prostatic calcifications. It is also a time consuming task and automated identification methods have been suggested as an improvement for both objectives. Multi-echo gradient echo (MEGRE) images have been utilized for manu
Glyoxalase I (GlxI) is an important enzyme that catalyzes the detoxification of methylglyoxal (MG) with the help of glutathione (H-SG). It is currently unclear whether MG and H-SG are substrates of GlxI or whether the enzyme processes hemithioacetal (HTA), which is nonenzymatically formed from MG and H-SG. Most previous studies have concentrated on the latter mechanism. Here, we study the two-subs
Failure in wood is commonly considered as a sign of properly chosen adhesive for wood adhesive joints. It is argued that as the adhesive is stronger than the surrounding wood material, no concern has to be given to the adhesive properties in joint design. However, by means of theoretical arguments in combination with experimental experience in the present study, it is stated that local bond line p
Context. Although thousands of exoplanets have been discovered to date, far fewer have been fully characterised, in particular super-Earths. The KESPRINT consortium identified K2-216 as a planetary candidate host star in the K2 space mission Campaign 8 field with a transiting super-Earth. The planet has recently been validated as well. Aims. Our aim was to confirm the detection and derive the main
Aggrecan (ACAN) is localized in the intervertebral disc (IVD) in unique compartment-specific patterns where it contributes to the tissue structure and mechanical function together with collagens. The extracellular matrix (ECM) of the IVD undergoes degenerative changes during aging, misuse or trauma, which inevitably alter the biochemical and biomechanical properties of the tissue. A deeper underst
De första levande organismerna uppstod på jorden när den funnits i 1,5 miljarder år. Under de följande tre miljarder åren bildades livet på jorden, och existerade i harmoni, med gravitation, kosmisk-strålning, elektriska och magnetiska fält och dess cyklisk-hemlighetsfulla variationer medan exponeringen från den naturlga mikrovågstrålningen var endast i storleksordningen 210-15 W/kg. Det var i deOur team of the clinical researchers in Lund, Sweden, found that electromagnetic radiation, such as those used in mobile communications, even at shallow power values, cause users’ blood albumin to leak through the blood-brain barrier “BBB” into the brain tissue. The BBB is supposed to protect the brain against unwanted and toxic molecules potentially present in the blood, to transfer to the brain
Involving professionals in research can ensure the acquisition of knowledge, that is relevant, applicable and sustainable. Professionals are people who work in health systems, or organisations that contribute to health systems, such as practitioners, managers or other decision-makers. They have context-specific knowledge which the researchers often lack. Therefore, when they are involved in resear
Cows produce saliva in very large quantities to lubricate and facilitate food processing. Estimates indicate an amount of 50–150 L per day. Human saliva has previously been found to contain numerous antibacterial components, such as lysozyme, histatins, members of the S-100 family and lactoferrin, to limit pathogen colonization. Cows depend on a complex microbial community in their digestive syste
BACKGROUND AND OBJECTIVES: Stroke genetic research has made substantial progress in the past decade. Its recovery application, however, remains behind, in part due to its reliance on the modified Rankin Scale (mRS) score as a measure of poststroke outcome. The mRS does not map well to biological processes because numerous psychosocial factors drive much of what the mRS captures. Second, the mRS co
