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The aim of the present study is to study the Abscopal regression of subcutaneously implanted N29 rat glioma after immunization with syngeneic IFNg secreting cells and treatment of contra-lateral tumours with pulsed electric fields (PEF) and/or radiation therapy (RT). The study was performed on rats of the Fischer-344 strain with rat glioma N29 tumours implanted subcutaneously on the flank or on bo
Background: The observation of differences in the way apparently similar patients are treated from one health care setting to another, i.e., practice variation, have been recognized in numerous studies. The variations across the health care settings have been shown to exist for different outcomes. However, any measurement of any system will reveal some form of variation and this normal inevitable
Breast cancer is a truly heterogenous disease, reflected in the existence of a wide spectrum of phenotypic subsets of tumours with varying intrinsic aggressiveness as well as ability to respond to a given treatment. Recent advances in large-scale genomic and proteomic screening techniques have confirmed this heterogeneity also at a molecular level, but there is still a bottleneck to be overcome be
Popular Abstract in Swedish Avhandlingen är indelad i två delar. I den första delen studeras hur kommunikation påverkar utfall i strategiska situationer, så kallade spel. Den andra delen studerar individers riskpreferenser. Metodologiskt förlitar sig avhandlingen till största delen på ekonomiska experiment. I kapitel 2 till 4, som är författade tillsammans med Ola Andersson, studeras effekterna aThis thesis is divided into two distinct parts. The first part studies communication in games and the second part investigates individual decision making under risk. Chapters 2 – 4, co-authored with Ola Andersson, investigate communication and renegotiation in dynamic games. In Chapter 2, Bertrand supergames with non-binding communication are used to study price formation and stability of collus
Commitment to involuntary care is a multistage process comprising many different aspects; legal, psychological, medical, social and ethical among others. It can also be analyzed from the perspective of a continuum starting from the report to the social authorities, the evaluations on whether to commit or not, the actual commitment and aftercare following involuntary treatment. Enhancing knowledge
The work presented here aims at producing hydrogen for proton-exchange fuel-cell applications from hydrocarbons. This thesis describes an integrated catalytic converter comprising a steam-reforming reactor (heat of reaction supplied by catalytic combustion), a water-gas shift reactor and a preferential oxidation of carbon monoxide reactor, and the work performed on the fuel processing catalysts th
Popular Abstract in Swedish Denna avhandling presenterar resultat från experimentella studier av tensiders och enzymers beteenden vid modellytor. Ellipsometri var den i huvudsak använda tekniken i dessa undersökningar. Studier av tensidadsorption i statiska och dynamiska vätningssituationer initierades för att undersöka adsorptionsbeteenden i närheten av trefaslinjen under dynamisk vätning. I falThis thesis presents results from experimental studies of the interfacial behaviour of surfactants and enzymes at model surfaces. The main technique used throughout the work was ellipsometry. Studies of surfactant adsorption in static and dynamic wetting situations were performed to investigate adsorption behaviour close to the three-phase contact line (tpl) during dynamic wetting. It was demonst
Popular Abstract in Swedish Fotosyntesen är nödvändig för vårt liv på jordklotet. Fotosyntes utförs huvudsakligen av gröna växter och dessutom av vissa bakterier. Dessa organismer absorberar energin i solljuset och omvandlar den till kemisk energi i form av till exempel kolhydrater och fett som vi människor och djur sedan kan förbränna och utvinna energi ifrån. Fotosyntesen utförs av ett flertal pPSII catalyses the light-induced water splitting process which leads to electron transfer through the thylakoid membrane and formation of energy rich molecules. Several redox components including a Mn4Ca, an amino acid residueYZ, two special Chl molecules P680, two Pheo and two quinone molecules participate in this process. Another component of PSII which interacts magnetically with Mn4Ca is D2-Ty
The use of Penman-Monteith (PM) equation in thermal remote sensing based surface energy balance modeling is not prevalent due to the unavailability of any direct method to integrate thermal data into the PM equation and due to the lack of physical models expressing the surface (or stomatal) and boundary layer conductances (g(S) and g(B)) as a function of surface temperature. Here we demonstrate a
I avtalsrätten utgörs en central princip av pacta sunt servanda – löften ska hållas. Denna princip, som på ytan kanske inte ser ut att innebära några svårigheter, kan leda till bekymmer sett inom ramen för användandet av letter of intent respektive letter of comfort. I det moderna näringslivet har ett flertal sätt att sluta kommersiella avtal vuxit fram och lett till att avtalslagens anbud-accepOne fundamental principle within the field of contract law is pacta sunt servanda - agreements must be kept. This principle, which on the surface might not seem very complicated, may cause problems when applied on the use of letter of intent and letter of comfort. In the modern business world several ways of entering commercial contracts have arisen, causing the offer-and-acceptance-model provide
För att bättre kunna förebygga att skelettet bryts ner vid långvarig vila eller vid sjukdomarsom osteopenia och osteoporos, behövs bättre förståelse för de processer somstyr detta. I den här avhandlingen antas att den primära orsaken till bentillväxt är enförändring i den kemiska miljön i benet. Förändringen antas orsakas av att tillväxtstimulerandeämnen transporteras genom benet till den plats däIn order to prevent or modify bone degeneration due to rest or due to diseases such as osteopenia and osteoporosis, the modeling and remodeling of bone tissue must be better understood. In this thesis it is assumed that the primary condition leading to bone growth is a change of the chemical environment caused by transport of matter resulting from stress driven diffusion. The change in the chemica
“Those who can make you believe absurdities can make you commit atrocities” is a famous aphorism commonly attributed to Voltaire. The choice to publish under an alias for François-Marie Arouet, reveals that there was some sort of awareness of the relationship between power, knowledge, truth and people’s tyrannical tendencies on his part. What our dear enlightened friend could most likely not fores
Popular Abstract in Swedish Mag-tarmkanalen utgör kroppens största hormon-producerande organ. Många av de hormon-producerande cellernas funktion är ännu okänd och mycket lite är känt om den betydelse de kan ha vid olika sjukdomar i mag-tarmkanalen. I magsäckens syraproducerande del (fundus) finns 4 hormon-producerande celler, av vilka ECL cellen (65 %) och A-lika cellen (25 %) tillsammans utgör caThe ECL cells constitute a prominent endocrine cell population in the acid-producing part of the stomach. They are controlled by circulating gastrin released from G-cells in the antrum. In response to gastrin, they secrete histamine, that in turn stimulates the parietal cell to secrete acid. The first aim of the study was to prepare isolated ECL cells of high purity and to study and identify regul
Amelogenin is an extracellular matrix protein involved in formation of enamel during early tooth development. By interacting with the forming enamel crystallites amelogenin affects their growth, so that highly elongated hydroxyapatite crystals are formed. Early during the enamel formation amelogenin is proteolytically processed, which is essential for correct enamel formation. However, the exact m
This thesis is based on three scientific papers dealing with different models for coordinated control of multi-stage inventory systems. The ability to control multi-echelon inventory systems, is paramount for reducing tied up capital and inventory costs in large distribution systems. It is also one key issue in achieving efficient supply chain management. We focus our attention on a general distr
Popular Abstract in Swedish Yttre faktorerna i omgivningen som UV-strålning från solen, rökning, läkemedel, maten och påfrestande livssituationer kan leda till att kroppens celler börjar överproducera molekyler som kallas syrefria radikaler. Dessa molekyler reagerar kemist mycket lätt med omgivande ämnen. När syrefria radikaler bildas i kroppen i normala mängder ingår de som en del av immunförsvarOxidative stress can cause damage to DNA, proteins and lipids and is associated with inflammation and various human diseases as cancer, atherosclerosis, and autoimmune diseases. Polyphenol-rich diet, such as fruits and berries, may act as antioxidants and prevent oxidative stress and, thereby, associated diseases. Administration of lactic acid bacteria (LAB) can affect the microflora in the gastro
Genom att teckna en avbrottsförsäkring kan ett företag skydda sig mot de inkomstförluster som riskerar att uppstå om verksamheten drabbas av ett avbrott. För att full försäkringsersättning ska utgå vid ett avbrott fordras emellertid att det försäkrade företaget inte, i strid med 8 kap. 11 § försäkringsavtalslagen (FAL), förvärrat det inträffade försäkringsfallet eller åsidosatt sin plikt att, enliBy entering a business interruption insurance policy agreement, a company can protect itself against the risk of sustaining economic losses following an interruption of the company’s business. In order for the insured company to receive full compensation in the event of an interruption, the company must not, in violation of Section 11 of Chapter 8 of the Insurance Contracts Act (ICA), have exacerb
The transfer of 210Po and 210Pb between various compartments in the terrestrial environment has been analysed by using various published data. The average activity concentration of 210Po in soil is 61 ± 14 Bq.kg-1 d.w. with a median (50%) value of 44 Bq.kg-1 d.w. Ground water concentrations of 210Po in drilled wells might be as high as 6.5 Bq/l. But in regular drinking water it is just about 3-5
Innovation plays an important role in organization survival and longevity. This is especially true in the retail industry; there is a growing acknowledgment of the role of innovation in retail practice, as maintaining the status quo might prove insufficient, especially for traditional retailers, in addressing the enormous challenges they are facing driven by technological developments and evolving
Geotechnical engineering is the science dealing with mechanics of soils and rocks and its engineering applications. Geotechnical engineering projects vary in a wide range, from evaluation of the stability of natural slopes and man-made soil deposits, to the design of earthworks and foundations. Traditional methods, using manual calculations or simplified computational methods, do not, as a rule, t
