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Mitochondrial toxicity of metformin and phenformin in human peripheral blood cells assessed by high-resolution respirometry

Popular science summary Do metformin and phenformin cause toxicity to mitochondria of human blood cells? Metformin and phenformin are anti-diabetic drugs associated with lactic acidosis as a rare side effect. This side effect is thought to be due to drug-induced mitochondrial dysfunction. In this project, the mitochondrial toxicity of metformin and phenformin was assessed in human blood cells. I

Market analysis – mapping of customer needs and buying behaviours within the furniture market segment for care and healthcare

Purpose The purpose of the study has been to estimate the size of the market segment, identify strategically important customers and interesting parts of the segment as well as create an understanding of customer needs when buying furniture for their businesses where care and healthcare is practised. Method The study has been of an exploratory nature with a case study approach since the purpose of

Limitation of algorithms for quantitative label-free LC-MS-based proteomics

Abstract Over the past decade, mass spectrometry has had an essential role in improvement of proteomics techniques. New instrument and analytical protocol developments have made mass spectrometry one of the most widely used analytical methods in quantitative proteomics. Today one of the commonly used protocols in proteomics is digestion of proteins to peptides and analysis of the peptides with li

ACCOUNTING EDUCATION IN VIETNAM THROUGH THE LENSES OF LEGITIMACY THEORY AND STAKEHOLDER THEORY

Seminar date: 30 May 2013 Course: BUSN69 – Degree Project in Accounting and Auditing Authors: Alex Trung Huỳnh and Thảo Trần Supervisors: Anne Loft and Maria Bengtsson Key words: accounting education, university, Vietnam, employability, legitimacy, stakeholders. Background and problem: Since Đổi Mới, the Economic Reformation, in 1986, Vietnam has seen a huge improvement in terms of economic d

Otillräkneliga eller allvarligt psykiskt störda lagöverträdare - Vilka psykiskt störda lagöverträdare som bör särbehandlas, och framför allt hur

Psykiskt störda lagöverträdare har ofta inte samma förutsättningar som andra att följa lagen då de kan ha en annan föreställning av, eller en annan förmåga att resonera kring, verkligheten. Det är vår föreställning av verkligheten som ger oss skäl att göra eller att inte göra vissa saker, och vår uppfattning om vilka följder vårt handlande kommer att få, får betydelse för om vi företar handlingen Mentally disordered offenders often do not have the same preconditions as others to follow the law as they may have a different perception of, or a different ability to reason about, reality. It is our perception of reality that gives us reason to do or not do certain things, and our perception of the consequences our actions will have has an impact on whether we undertake them or not. If you have

The Structure-Function Relationship and Evolution of Deoxyribonucleoside Kinases

Popular Abstract in English Deoxyribonucleoside triphosphates (dNTPs) are the building blocks of DNA and the balanced cellular dNTP pools are of extreme importance to maintain the genomic stability and overall function of the cell. Primarily, two different pathways exist in most of the organisms that are responsible for providing dNTPs. One is called the de novo pathway where dNTPs are formed fromThe synthesis of deoxyribonucleoside triphosphates (dNTPs), building blocks of DNA, can be achieved by two different pathways in the cell. One is called de novo synthesis and the other is known as salvage pathway. The de novo pathway involves synthesis of dNTPs by utilizing basic molecules like sugars, amino acids, CO2, NH3, etc., while in the other pathway, dNTPs are formed by salvaging intra- or

Longitudinal 10-year changes in dietary intake and associations with cardio-metabolic risk factors in the Northern Sweden Health and Disease Study

Background: Dietary risks today constitute the largest proportion of disability-adjusted life years (DALYs) globally and in Sweden. An increasing number of people today consume highly processed foods high in saturated fat, refined sugar and salt and low in dietary fiber, vitamins and minerals. It is important that dietary trends over time are monitored to predict changes in disease risk. Methods:

Tumor Necrosis Factor-α Underlies Loss of Cortical Dendritic Spine Density in a Mouse Model of Congestive Heart Failure

BACKGROUND: Heart failure (HF) is a progressive disorder characterized by reduced cardiac output and increased peripheral resistance, ultimately leading to tissue perfusion deficits and devastating consequences for several organs including the brain. We previously described a tumor necrosis factor-α (TNF-α)-dependent enhancement of posterior cerebral artery tone and concomitant reduced cerebral bl

Increased plasma levels of islet amyloid polypeptide in patients with primary hyperparathyroidism

Amylin, also named islet amyloid polypeptide (IAPP), is a protein that is processed and released from pancreatic beta-cells in parallel with insulin. Islet amyloid polypeptide is currently studied with regard to a role for insulin resistance in non-insulin-dependent diabetes. To elucidate a possible function of IAPP for impaired glucose tolerance in primary hyperparathyroidism (pHPT), we studied p

Muscle Tenderness in Women.

Popular Abstract in Swedish Muskelömhet hos kvinnor Smärttrösklar för tryck i skuldermuskulaturen (trapezius och deltoideus) i vila, efter muskel uttröttning och efter smärtsam stimulering Smärta i muskler och leder och besvär i form av upplevd trötthet i musklerna är vanligt förekommande problem, särskilt hos den kvinnliga delen av befolkningen. Man har ansett detta kopplat till olika belastandeLongstanding pain experienced from the musculoskeletal system is reported by one third of the Swedish population. The underlying mechanisms are not known in the majority of cases. In the present studies, the changes in pressure pain thresholds (PPTs) over the trapezius and deltoid muscles after a unilateral static contraction of maximal duration of one arm was measured in healthy females (n=25) a

Competitive Protein Adsorption during Spray-drying

The aim of this thesis was to study competitive adsorption of milk proteins during spray-drying. For this purpose, a new surface sensitive method was developed which measures the quantitative amount of specific proteins at the powder surface. The new method is based on steady-state fluorescence measurement of pyrene labelled proteins with oxygen gas phase quenching at the powder surface. The milk

Ammonia emissions from deciduous forest after leaf fall

The understanding of biochemical feedback mechanisms in the climate system is lacking knowledge in relation to bi-directional ammonia (NH3) exchange between natural ecosystems and the atmosphere. We therefore study the atmospheric NH3 fluxes during a 25-day period during autumn 2010 (21 October to 15 November) for the Danish beech forest Lille Bogeskov to address the hypothesis that NH3 emissions

Return to Work and Participation in Society after Out-of-Hospital Cardiac Arrest

Background: The aim of this study was to describe out-of-hospital cardiac arrest (OHCA) survivors' ability to participate in activities of everyday life and society, including return to work. The specific aim was to evaluate potential effects of cognitive impairment. Methods and Results: Two hundred eighty-seven OHCA survivors included in the TTM trial (Target Temperature Management) and 119 match

European pollen-based REVEALS land-cover reconstructions for the Holocene : Methodology, mapping and potentials

Quantitative reconstructions of past land cover are necessary to determine the processes involved in climate-human-land-cover interactions. We present the first temporally continuous and most spatially extensive pollen-based land-cover reconstruction for Europe over the Holocene (last 11g€¯700g€¯calg€¯yrg€¯BP). We describe how vegetation cover has been quantified from pollen records at a 11 spatia

Detection of inflammatory biomarkers associated with postural orthostatic tachycardia syndrome: insights from the SYSTEMA cohort

Background: Postural Orthostatic Tachycardia Syndrome (POTS) is a cardiovascular dysautonomic condition affecting predominantly young women. POTS is defined as the presence of chronic symptoms of orthostatic intolerance associated with an increased heart rate ≥30 bpm, or heart rate exceeding 120 bpm, within 10 minutes of standing or head-up tilt in the absence of orthostatic hypotension. The etio

How to apply for your second semester

How to apply for your second semester | Student website LTH Skip to main content This site uses cookies to enhance the user experience. By continuing to use the site you agree that cookies are used according to our Cookie Policy (on the website of LTH) . Essential cookies These cookies are necessary for the website to function and cannot be turned off in our systems. These cookies do not store any

https://www.student.lth.se/english/exchange-students/preparing-for-your-studies/how-to-apply/ - 2026-06-06

Architecture, Digital Architecture and Emergent Futures or Sustainable Urban Design (MSc)

Architecture, Digital Architecture and Emergent Futures or Sustainable Urban Design (MSc) | Student website LTH Skip to main content This site uses cookies to enhance the user experience. By continuing to use the site you agree that cookies are used according to our Cookie Policy (on the website of LTH) . Essential cookies These cookies are necessary for the website to function and cannot be turne

https://www.student.lth.se/english/masters-students/degree-project/architecture-or-sustainable-urban-design-msc/ - 2026-06-06

2025 HT_LP2 FMSF50 CEQ-kursutvärdering ver 9.0 (2021-01-23) LTH

2025 HT_LP2 FMSF50 CEQ-kursutvärdering ver 9.0 (2021-01-23) LTH Arbetsrapport CEQ, FMSF50 Basfakta Kursnamn Matematisk statistik, allmän kurs Kurskod FMSF50 Högskolepoäng 7.5 hp Läsår 202526 Kursen slutade i läsperiod HT_LP2 Program samtliga Antal registrerade på kursen 190 Antal enkätsvar/svarsfrekvens 34 / 18 % Antal män som svarat 18 Antal kvinnor som svarat 15 Arbetstid enligt läro- och timpla

https://www.maths.lu.se/fileadmin/maths/utbildning_education/KursutvHT25/FMSF50_2025_HT_LP2_arbetsrapport.pdf - 2026-06-06

LUCSUS 2023 tillganglighetspassad

Annual Report 2023 Annual Report 2023 LUND UNIVERSITY CENTRE FOR SUSTAINABILITY STUDIES (LUCSUS) Contents Words from the director 3........................................................................................................................... Research 4.......................................................................................................................................

https://www.lucsus.lu.se/sites/lucsus.lu.se/files/2024-06/LUCSUS%202023_tillganglighetspassad.pdf - 2026-06-06

BanretiPoster.ppt

BanretiPoster.ppt 1 RESTRICTED DISCRIMINATION BETWEEN LOCAL ECONOMY AND GLOBAL ECONOMY IN AGRAMMATIC APHASIA Zoltán BÁNRÉTI Research Institute for Linguistics of the Hungarian Academy of Sciences, Budapest, Hungary banreti@nytud.hu The problem : binding principles in aphasia 1. The economy constraints of the grammar is somehow restricted in the performance of agrammatic aphasic subjects ( Vasi_-Av

https://konferens.ht.lu.se/fileadmin/user_upload/sol/ovrigt/konferens_BrainTalk/Banreti.pdf - 2026-06-06