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Acquired clonal chromosome aberrations, closely associated with leukemogenesis, are found in many hematologic malignancies. Although the balanced rearrangements, such as translocations and inversions, are the ones most commonly thought of in the context of leukemias, gains of chromosomes ? e.g.., trisomies ? are also frequent. Little is known about the biologic outcome, the pathogenetic significan
Popular Abstract in Swedish Tunnelbygget genom Hallandsåsen har utvecklats på ett sådant sätt och fått sådana konsekvenser, att frågan hur projektet skall förstås och förklaras är viktig. Vill man studera vilka mekanismer i samhället som kan förhindra projektets förlopp eller dess konsekvenser, bör man först förstå projektet. Matthias Baiers bok handlar om hur man med normer kan förstå och beskrivIn 1992 Swedens biggest tunnelproject begun. Two 8.5 km tunnels should cross a big ridge in southern Sweden which was seen as an obstacle to a fast and efficient railway line connecting Oslo and Gothenburg with Malmö and Copenhagen. However, the project had to stop in 1997 due to environmental damages. With only a third of the tunnel accomplished, the project was also much delayed and had a heavy
Ultra-fast substitution of chloride for bromide, iodide, azide and thiocyanate trans to ethene in Zeise's anion, [PtCl3(C2H4)](-), 1, has been investigated in methanol solvent by use of cryo temperature diode array stopped-flow spectrophotometry. Reactions follow the usual two-term rate law for square-planar substitutions, k(obs)=k(1)+k(2)[Y] (where k(1)=k(MeOH) [MeOH]), with k(1)=118+/-10 s(-1) a
Optical region spectra for a number of upper main sequence chemically peculiar (CP) stars have been observed to study singly and doubly ionized praseodymium and neodymium lines. In order to improve existing atomic data of these elements, laboratory measurements have been carried out with the Lund VUV Fourier Transform Spectrometer (FTS). From these measurements wavelengths and hyperfine structure
BACKGROUND: Global development goals increasingly rely on country-specific estimates for benchmarking a nation's progress. To meet this need, the Global Burden of Diseases, Injuries, and Risk Factors Study (GBD) 2016 estimated global, regional, national, and, for selected locations, subnational cause-specific mortality beginning in the year 1980. Here we report an update to that study, making use
In this study a novel comparison of CFD, measured data and a ID-model is presented for a Twin-scroll turbocharger turbine stage. Both full and single admission flow divisions were taken into consideration and shown to represent "on-engine" conditions in the high and low engine rpm range respectively for a heavy-duty 6-cylinder diesel engine. With this in mind, the turbine stage was evaluated for e
Type 2 diabetes (T2D) is a common metabolic disease and its prevalence is increasing worldwide. Adipose tissue plays an important role in metabolic processes. Environmental factors may affect metabolic phenotypes and epigenetics may mediate this influence. We used Illumina 450k microarrays to study correlations between epigenetic patterns in human adipose tissue and environmental factors such as h
Antalet allvarliga konsekvenser av katastrofer i världen har ökat, vilket lett till ett internationellt initiativ för att främja utvecklingen av nationella strategier för katastrofriskreducering (DRR) och resiliens. Ett av de globala målen i Sendairamverket för katastrofriskreducering 2015-2030, antaget av FN:s medlemsstater, handlar om att länderna ska ta fram strategier kopplat till DRR (mål E).Increasing impacts from hazards worldwide, including Sweden, have prompted international efforts to promote the development of national strategies for disaster risk reduction (DRR) and resilience to reduce associated impacts and support sustainable development. The development of such strategies is global target E of the Sendai Framework for DRR 2015-2030, which was adopted in 2015 by Sweden and o
Climate change is exposing high-latitude systems to warming and a shift towards more shrub-dominated plant communities, resulting in increased leaf-litter inputs at the soil surface, and more labile root-derived organic matter (OM) input in the soil profile. Labile OM can stimulate the mineralization of soil organic matter (SOM); a phenomenon termed “priming.” In N-poor subarctic soils, it is hypo
Background: Intensive rehabilitation is one of the most important aspects of care for people with stroke, and there is evidence that it leads to better recovery and higher levels of independence. However, pressure on resources in government funded secondary and primary healthcare settings means that for many people with stroke, intense rehabilitation is not available. Effective and efficient ways
The interest in diffusion imaging with nuclear magnetic resonance techniques has increased during the last few years. The main reason is the possibility of early diagnosis of acute ischaemic stroke, at a time when conventional MR techniques and computerised tomography fail. The purpose of this study was to develop and evaluate methods for the measurement of water self-diffusion in vivo usin
The composition of the colonic microflora is essential for the health of the human host. To be able to survive, the microflora is dependent of a continuous supply of substrate. In this respect dietary fibre and other indigestible carbohydrates, of which the consumption in affluent societies is generally low, are of great importance. Numerous of studies have demonstrated beneficial effects of dieta
The rapid development of digitization in recent years has meant enormous opportunities for improvement and efficiency of various activities within a company. Furthermore, the digital era has meant that digital tools are becoming more common for additional sectors and businesses. Yet, the construction industry seems to lack in this development. There is a general consensus that the construction ind
Ojämlikhet, i termer av hur resurser fördelas mellan olika kategorier av människor, är ett genomgripande samhällsfenomen. Den svenska arbetsmarknaden är inget undantag och uppvisar en betydande grad av klassad, etnifierad och könad ojämlikhet när det gäller tillgång till kontroll och makt över produktionsförhållanden. Denna avhandling syftar till att bidra med kunskap om hur och varför ojämlikhetsInequality, in terms of how resources are distributed between different categories of people is a pervasive phenomenon in society. The Swedish labour market is no exception, exhibiting a significant degree of classed, ethnified and gendered inequality in terms of access to control and power over production conditions. This thesis aims to contribute knowledge about how and why inequality regimes ar
Environmental loads, such as wind and river flow, play an essential role in the structural design and structural assessment of long-span bridges. Climate change and extreme climatic events are threats to the reliability and safety of the transport network. This has led to a growing demand for digital twin models to investigate the resilience of bridges under extreme climate conditions. Kalix bridg
This paper proposes and explains a type of diagrams which share some of the characteristics distinctive of axial maps, while also differing substantially in some other aspects. A main discussion in Space Syntax is the capacity of different diagrammatic representations to describe relevant morphological characteristics of space: convex maps or visibility graphs at the scale of buildings; axial maps
Feedbacks from the climate to other components of the coupled human-Earth system are expected to strongly influence the co-evolution of human society and its environment. Representing these feedback loops between climate and society, via the Earth system's response to human activities and the subsequent effect back onto social systems, is essential in order to fully explore the dynamics of the cou
The use of celestial or geomagnetic orientation cues can lead migratory birds along different migration routes during the migratory journeys, e.g. great circle routes (approximate), geographic or magnetic loxodromes. Orientation cage experiments have indicated that migrating birds are capable of detecting magnetic compass information at high northern latitudes even at very steep angles of inclinat
Coastal areas around the world are being shaped by many natural phenomena, as well as by man-induced activities. Hydrodynamic phenomena such as wind-generated waves, extreme storms and seasonal tides cause a continued change in topography and the natural sediment formation in the nearshore zone as a result of erosion and accumulation. Therefore, the nature of the nearshore zone and its protection
