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Twenty-five years ago, the book The Ecology of Adaptive Radiation by Dolph Schluter presented a testable framework that integrated ecology, genetics, and natural history to explain the mechanisms driving adaptive radiation, the rapid diversification of a single lineage into multiple species occupying distinct ecological niches. One important contribution was to re-orientate the study of adaptive r
The purpose of this study was to contribute to the development of a model including parameters for matching health-care services to patients. Inspired by ‘engaged scholarship’, the researchers practised continuous and close collaboration with practitioners at Region Skane in Sweden. The agenda was based on questions and experiences that evolved from theory and experience gained during previous res
Parkinson’s disease (PD) is a neurodegenerative disorder characterized byprogressive loss of dopaminergic (DA) neurons in the substantia nigra parscompacta (SNpc) of the midbrain. Loss of dopaminergic signalling leads to rigidity,resting tremor, and difficulties controlling voluntary movements, contributing to asignificantly reduced quality of life for the patient. Alpha-synuclein (α-syn) is a pre
Pedal acceleration time (PAT) has recently attracted clinical interest for assessing peripheral arterial disease (PAD), particularly in patients in whom ankle–brachial index (ABI) or toe pressure measurements are unreliable or not feasible, yet its diagnostic worth has not been systematically evaluated. We searched MEDLINE, Embase, ScienceDirect, and the Cochrane Library from inception to January
Hairy cell leukemia (HCL) and HCL variant (HCLv) are distinct, rare, and chronic splenic B-cell lymphomas/leukemias that partially overlap in clinicopathologic presentation but differ in genetic basis, prognosis, and management. HCL is caused by the BRAF-V600E kinase–activating mutation in >95% of the patients, usually has excellent responses to chemotherapy with purine analogues, and is also amen
This article examines Norrköping, Sweden, as a case of industrial transformation through the adaptive reuse of industrial heritage. Once a major center of Swedish manufacturing, Norrköping experienced significant industrial decline during the twentieth century. Rather than treating its former factories and industrial infrastructure solely as remnants of the past, the city has integrated them into
The COVID-19 pandemic led to substantial changes in working conditions in academia. This study aimed to explore how academics’ perceptions of job demands,resources and occupational well-being have changed since the COVID-19 pandemic, as well as their expectations and concerns regarding future working practices. To achieve this aim, we conducted a qualitative follow-up study with 16academics who pa
The international legal framework regulating the problem of human trafficking contains the presumption that the return of victims of human trafficking to their countries of origin is the standard resolution for their cases. However, victims might have legitimate reasons for not wanting to go back. For those victims, resort to the legal framework of the European Convention on Human Rights could be
Background: Nervous system involvement is among the most complex and consequential aspects of systemic lupus erythematosus (SLE). It includes clinically overt neuropsychiatric SLE (NPSLE) manifestations and potentially subclinical involvement. This thesis aimed to increase the understanding of nervous system involvement in SLE through biomarker studies and a population-based epidemiological study.
Directly coupling photovoltaic (PV) arrays to proton exchange membrane (PEM) electrolysers is among the cheapest routes to green hydrogen, but without a power converter the operating point is mismatched to the solar maximum-power point, and that mismatch shifts minute-to-minute with cloud cover. Which coupling strategy maximizes hydrogen yield under realistic solar variability, and whether the ans
