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Background and Purpose-We have previously shown that delivery of brain-derived neurotrophic factor (BDNF) through direct intrahippocampal gene transduction with a viral vector suppresses the formation of new dentate granule cells triggered by global forebrain ischemia. Here, we investigated whether inhibition of endogenous BDNF alters ischemia-induced neurogenesis in the dentate gyrus. Methods-Rat

Due to rapid development of bacterial resistance against antibiotics, an emerging health crisis is underway, where ‘simple’ infections may no longer be treatable. Antimicrobial peptides (AMPs) constitute a class of substances attracting interest in this context. So far, research on AMPs has primarily focused on the identification of potent and selective peptides, as well as on the action mode of s

Sponge phase nanoparticles are lipid-based particles with a porous structure, forming pores with sizes up to 13 nm in diameter. These particles have been proposed for drug delivery by loading cargo within the pores, similar to how ionisable nanoparticles are used today. The larger pores could allow for larger cargo to be delivered to cells. Sponge phase nanoparticles, 277 ± 29 nm in diameter, were

Nanoparticle-based targeted drug delivery holds promise for treatment of cancers. However, most approaches fail to be translated into clinical success due to ineffective tumor targeting in vivo. Here, the delivery potential of mesoporous silica nanoparticles (MSN) functionalized with targeting ligands for epidermal growth factor receptor and C─C chemokine receptor type 2 is explored in lung tumors

The controlled delivery of micronutrients to soil and plants is essential to increase agricultural yields. However, this is today achieved using fossil fuel-derived plastic carriers, posing environmental risks and contributing to global carbon emissions. In this work, a novel and efficient way to prepare biodegradable zinc-impregnated cellulose acetate beads for use as controlled release fertilize

Supramolecular hydrogels have attracted increasing attention in drug delivery, tissue engineering, and injectable biomaterials because of their high water content, good biocompatibility, and dynamic network structures. Cyclodextrin-based supramolecular systems can form network structures through host–guest interactions. These systems usually require mild cross-linking conditions and allow flexible

Protein therapeutics need to be formulated into an amorphous solid state to be stabilized, and this is efficiently done by spray drying together with a sugar matrix excipient. The characteristics of the produced powder are strongly dependent on process parameters, and therefore, spray drying offers the possibility of advanced particle engineering. In this thesis, trypsin was spray dried as a model

Universitetslektor Kontaktinformation E-post: paul [dot] pierce [at] ics [dot] lu [dot] seOrganisation Institutionen för informatik Rumsnummer: EC2-225 Hämtställe: 10 WebbplatsPaul Pierces profil i Lunds universitets forskningsportal Publikationer Visar av publikationer. Sorterade efter år och sen titel. Filtrera efter typ AllaArtikel i vetenskaplig tidskriftDoktorsavhandling (monografi)Kapitel sa

https://www.ehl.lu.se/paul-pierce - 2026-07-14

Inconel 718 is a Ni-based superalloy that can perform excellently at elevated temperatures. However, surface and subsurface damages in the form of microstructural and property changes and tensile residual stresses are common in a machined Inconel 718 component because of its poor machinability. Such damages have a significant influence on performance and the life time of the part. To characterise

In this dissertation, we discuss how buyers practice purchasing strategies in an asymmetric power situation favoring suppliers, and how their purchasing strategies practiced impact their purchasing power and buyer-supplier relationships. Organizations enter exchange relationships to access required resources not produced internally, and are exposed to uncertainty from not being able to fully contr

https://www.keg.lu.se/sites/keg.lu.se/files/utvc25_updated_2017-08-11.pdf - 2026-07-15