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This report is the result of a Master Thesis project in Mechanical Engineering with Industrial Design at the Faculty of Engineering LTH at Lund University. The project was conducted in collaboration with ArjoHuntleigh AB, a company based in Malmö, Sweden. ArjoHuntleigh develops integrated healthcare solutions for people with low mobility and thereto related problems. The report describes the deve
The purpose of the study has been to gain an understanding of how socio-cultural structures and gender norms affect young women’s leadership possibilities. This has been explored through a qualitative case study focusing on how young women leaders, working with sexual and reproductive health rights issues, experience and pursue leadership in Zimbabwe. A theoretical framework based on contextual an
Realising social justice has been one of the central goals of the International Labour Organisation since its inception. Yet today the unique environment and dangers associated with working at sea make the world’s 1.2 million seafarers a particularly vulnerable group, both in terms of their physical safety and mental wellbeing, and concerning the realisation of social justice. Social justice is a
Study on value creation for acquiring companies in Sweden in the years 2002-2009. The study is carried out by using both event- and accounting study methodology and the value creation is studied in short, medium and long-term. We find significant positive average abnormal returns of 2.82% at the announcement, which is steady until 5 days post the announcement. We find no significant abnormal chang
Populärvetenskaplig sammanfattning Genen MYCN kodar för N-Myc, ett protein som fungerar som transkriptionsfaktor, det vill säga det kontrollerar vilka gener som transkriberas aktivt från DNA till RNA. Många neuroendokrina tumörer, speciellt neuroblastoma, uppvisar ofta onormalt höga nivåer av N-Myc, och eftersom N-Myc startar transkriptionen av många gener som är viktiga för cellens delning, tillvThe gene MYCN encodes a transcription factor with a fundamental role in many neuroendocrine tumors, especially neuroblastoma. The gene and protein are very similar to the closely related c-Myc protein, except for the 3´untranslated region (3´UTR), suggesting that it may be an important factor in determining their very different expression pattern at the post-transcriptional level. MicroRNA (miRNA)
I Sverige drabbas omkring 300 barn av cancer varje år och majoriteten av dem är bara fyra-fem år gamla när de får sin diagnos. Omkring två tredjedelar av barncancerdiagnoserna utgörs av leukemier, lymfom och hjärntumörer, medan den sista tredjedelen är olika solida tumörformer som njurtumörer och nervvävnadstumörer i buken. Cancersjukvårdens utveckling under de senaste årtiondena har medfört en avPurpose: The purpose of this study was to evaluate the impact of including PET (Positron Emission Tomography) in the process of pediatric radiation therapy planning. The aim was to study the effect on target volumes and how this in turn affects the resulting treatment plans. This study also aims to compare the estimated risks of various long-term complications and how the use of PET influences the
The adoption of the International Convention on Civil Liability for Bunker Oil Pollution Damage 2001 plugs a gap in the otherwise comprehensive international liability and compensation regime for ship-source pollution. Although liability for bunkers pollution from tankers was partially regulated by other civil liability regimes, bunker spills pollution from other types of vessels was left uncovere
Antibody-based microarrays is a rapidly evolving technology that has gone from the first proof-of-concept studies to more demanding proteome profiling applications, during the last years. Miniaturized microarrays can be printed with large number of antibodies harbouring predetermined specificities, capable of targeting high- as well as low-abundant analytes in complex, nonfractionated proteomes. C
Participation is about finding consensus in diversity and reflects a normative shift towards multiple-use values that recognise that forest management should blend multiple management objectives into a coherent set of practices. A framework to incorporate interest groups' values and needs into functional forest management systems has yet to be institutionalised in contemporary forest policy and ma
Gaussian wave models have been successfully used since the early 1950s to describe the development of random sea waves, particularly as input to dynamic simulation of the safety of ships and offshore structures. A drawback of the Gaussian model is that it produces stochastically symmetric waves, which is an unrealistic feature and can lead to unconservative safety estimates. The Gaussian model des
We present an algorithm for the computation of the stress field around a branched crack. The algorithm is based on an integral equation with good numerical properties. Our equation is obtained through a left regularization of an integral equation of Fredholm's first kind. Complex valued functions involving repeated products of square roots appear in the regularization. A new and effective scheme f
The hallmark of severe haemophilia, defined as a circulating level of factor (F) VIII (haemophilia A cases) or FIX (haemophilia B cases) of < 1%, is recurrent bleeding into muscles and joints (haemarthroses) from an early age of life. The inevitable result of such bleeding is progressive joint damage, leading to disabling arthritis that is typically evident within the first 2 decades of life in pe
The interactions between wild-type or mutant recombinant forms of human cystatin C and rat cathepsin B were characterized by measuring progress curves for substrate hydrolysis in the presence of inhibitor. The investigation was guided by the use of computer modeling and explores the possibility that amino acid residues in the N-terminal region of cystatin C interact with substrate-binding regions
We present a method for parametrizing the Zeeman effect in hydrogen-like systems in high-temperature plasmas, where the fine-structure is completely unresolved. The method is based on the observation that the different polarization components behave collectively like separate entities, with simple relations. The entire Zeeman pattern can then be reduced to just three components, whose dependence o
Through ethnographic accounts, the method of heat treatment of silica materials to improve the flaking qualities is shown to have been known almost worldwide. Some mesolithic and neolithic flint artifacts from southern Sweden were examined in order to determine if they too were heat treated. From several methods proving or indicating thermal alteration of flint, analysis using scanning electron mi
The present multidisciplinary study examined nigrostriatal dopamine and striatal amino acid transmission in the R6/1 line of transgenic Huntington's disease (HD) mice expressing exon 1 of the HD gene with 115 CAG repeats. Although the number of tyrosine hydroxylase-positive neurons was not reduced and nigrostriatal connectivity remained intact in 16-week-old R6/1 mice, the size of tyrosine hydroxy
The brackish water cyanobacterium Nodularia spumigena produce the hepatotoxic cyclic pentapeptide nodularin. Intoxications for both human as well as animal may arise when water reservoirs are contaminated with potentially toxic Nodularia species. Here, results of three independent methods for the determination of nodularin in different strains of N. spumigena are presented. The results obtained wi
Consider a parametrized family of general hidden Markov models, where both the observed and unobserved components take values in a complete separable metric space. We prove that the maximum likelihood estimator (MLE) of the parameter is strongly consistent under a rather minimal set of assumptions. As special cases of our main result, we obtain consistency in a large class of nonlinear state space
In 2004 at the ATLAS (A Toroidal LHC ApparatuS) combined test beam, one slice of the ATLAS barrel detector (including an Inner Detector set-up and the Liquid Argon calorimeter) was exposed to particles from the H8 SPS beam line at CERN. It was the first occasion to test the combined electron performance of ATLAS. This paper presents results obtained for the momentum measurement p with the Inner De
