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Chronic myeloid leukemia (CML) is characterized by a specific chromosome translocation, and its pathobiology is considered comparatively well understood. Thus, quantitative analysis of CML and its progression to blast crisis may help elucidate general mechanisms of carcinogenesis and cancer progression. Hitherto, it has been widely postulated that CML blast crisis originates mainly via cell-autono
Objective Neuropsychiatric events occur unpredictably in systemic lupus erythematosus (SLE) and most biomarker associations remain to be prospectively validated. This study examined a disease inception cohort of 1047 SLE patients to determine which autoantibodies at enrolment predicted subsequent neuropsychiatric events. Methods Patients with a recent SLE diagnosis were assessed prospectively for
Brain machine interfaces with chronically implanted microelectrode arrays for signal acquisition require algorithms for successful detection and classification of neural spikes. During the design of such algorithms, signals with a priori known characteristics need to be present. A common way to establish such signals is to model the recording environment, simulate the recordings and store ground t
Background: The next-to-next-to-next-to-leading order ((NLO)-L-3) nuclear energy density functional extends the standard Skyrme functional with new terms depending on higher-order derivatives of densities, introduced to gain better precision in the nuclear many-body calculations. A thorough study of the transformation properties of the functional with respect to different symmetries is required as
Fodor is infamous for his radical conceptual nativism, McDowell likewise well-known for suggesting that concepts extend “all the way out” into the world and arguing against what he calls (per Sellars) The Myth of the Given: the idea that non-conceptual percepts justify conceptual frameworks. One need not go so far as either researcher, however, in allowing merit to their arguments. It seems we are
Cities are crucial to mitigating climate change and can serve as sites for innovations, providing examples of ways to conduct effective politics in transport, energy and land-use. What does it take to become a model for climate politics? This article argues that a few innovative measures will not suffice. A common vision based on broad legitimacy is crucial to achieving this position. Using a theo
The weighted oscillator strengths (gf) and lifetimes for S VIII presented in this work were obtained by a multiconfigurational Hartree-Fock relativistic approach. In this calculation, the electrostatic energy parameters were optimized by a least-squares procedure in order to improve the adjustment to experimental energy levels. The values for gf and lifetimes were then calculated on the basis of t
This dissertation explores the nexus between sustainable tourism development and corporate social responsibility (CSR). It addresses the scope for CSR to promote sustainable tourism in an international development context. This objective was pursued by exploring three sub-questions: what tools have been used to stimulate social responsibility in tourism; how has ecotourism influenced social respon
Therapy-induced resistance remains a significant hurdle to achieve long-lasting responses and cures in cancer patients. We investigated the long-term consequences of genetically impaired angiogenesis by engineering multiple tumor models deprived of endoglin, a co-receptor for TGF-beta in endothelial cells actively engaged in angiogenesis. Tumors from endoglin-deficient mice adapted to the weakened
Inflammatory bowel disease (IBD) is a global disease affecting more than 3.5 million people in the world, resulting in a high burden to societies. More research on IBD is definitely in need to prevent the disease and treat IBD patients. The intestinal epithelial barriers of IBD patients are weakened due to the inflammation, thereby, enteric microbes in the gut may translocate to the circulating sy
This thesis explores the correlation between national role conceptions, national identities and sensemaking processes among South Korean and Swedish policy influencers during the Sunshine Policy years of 1998-2003. The study relies on in depth semi structured interviews with 10 policy influencers who work with North Korea policies. Starting from Holsti’s (1970) national role conceptions and Weick’
Title: HR Analytics for Competitive Advantage: Bringing organisational value while empowering the HR profession Authors: Elin Engsfelt & Louise Rosén Fång Supervisor: Rikard Larsson Problem definition: The HR profession has throughout history, and still has, a legitimacy problem, where the HR department typically becomes administrative support, rather than a strategic business partner. Purp
The Arctic faces massive challenges, and scholars estimate that parts of the Arctic are warming six times faster than the global mean. Consequently, the regions’ valuable resources are becoming more accessible due to climate change. These resources are argued as necessary for meeting global sustainable development challenges. Many scholars are additionally concerned that economic policy goals are
The Swedish government has set the goal of achieving carbon-neutrality by 2045. The production of cement currently accounts for 8% of CO2 emissions worldwide, with a similar figure also true of Sweden. A clear government strategy is therefore needed to work with and provide support to the cement industry for decarbonisation. The most developed pathway for cement decarbonisation in the literature i
The aim of the study at had was to explore the potential of Natural Capital Accounting (NCA) to integrate environment into business decision-making. In order to fulfill the aim, the research was split into three main parts. First, the existing views on what constitutes NCA were reviewed through a literature analysis of grey literature, and the working definition established. The study found that t
Separating valuable minerals from waste rock is an important step in the production of metals. This is for copper ore done through a process called flotation. A flotation series consists of tank cells in series where the minerals are collected in a froth on top of the cells. The level control of the flotation cells is important in order to be able to collect the froth. The first four flotation cel
Environmental tax measures have the potential to be great tools for achieving sustainable development goals in the EU. The different dimensions of sustainability need to be balanced in order to achieve sustainable development goals. In the EU, tax law has been focussed too much on the economic dimension, and too little on the environmental dimension, which could lead to environmental sustainabilit
This thesis investigates how urban experimentation is governed in the new development district in Sege park in Malmö. Together with with private developers and a local NGO the municipality test and experiment with solutions for how the sharing economy can contribute to reduce the future resident’s climate impact and living costs. By using the theoretical lens of governmentality this thesis focusse
