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INTRODUCTION AND MATERIALS AND METHODS: G-protein coupled receptors (GPCRs) play an important role in platelet aggregation. To identify new platelet GPCRs, a platelet gene expression profile was generated and validated using quantitative real-time PCR. RESULTS: In total, mRNA of 28 GPCR genes was detected in human platelets. The 12 most abundant platelet GPCR transcripts were: thrombin receptor PA
We present palaeomagnetic inclinations from Late Cretaceous-Early Tertiary deep-water carbonates obtained during ODP Leg 192 drilling at the Ontong Java Plateau (OJP) for the following periods: magnetochrons C33n (73.6-79.1 Ma), C32 (71.1-73.6 Ma), C27r-C31n (61.3-68.7 Ma) and C25-C26 (55.9-60.9 Ma). Compaction-induced inclination shallowing is considered to be negligible for the OJP sediments exa
Data from measurements on the body burden Of (CS)-C-134, Cs-137 and K-40 in various Swedish populations between 1959 and 2001 has been compiled into a national database. The compilation is a co-operation between the Departments of Radiation Physics in Malmo and Goteborg, the National Radiation Protection Authority (SSI) and the Swedish Defense Research Agency (FOI). In a previous study the effecti
In this thesis, the fluid dynamic properties of the conventional Rushton turbine and another impeller type, the Scaba Radial flow Gas dispersing Turbine (with six concave blades) are compared. For comparison, point-wise velocity measurements were made in the discharge of the two turbine types using Hot-Wire Anemometry in constant temperature mode (CTA) with a split film probe. For the time-average
Background and objective: Human studies of arterio-venous (AV) differences in drug concentrations and the consequences for pharmacokinetic modelling and concentration-effect relationships are very limited. We therefore investigated the intravenous and intra-arterial concentrations of alcohol (ethanol) during the absorption, distribution and elimination stages of alcohol metabolism in healthy men.
In this study, we show a significantly reduced assay time and a greatly increased bead recovery for a commercial Luminex-based multiplex diagnostic immunoassay by performing all liquid handling steps of the assay protocol in a non-contact acoustic trapping platform. The Luminex assay is designed for detecting antibodies in poultry serum for infectious bursal disease virus, infectious bronchitis vi
Continuous supermacroporous chromatographic columns with anion-exchange ligands [2-(dimethylanlino)ethyl group] and immobilized metal affinity (IMA) ligands (Cu2+-loaded iminodiacetic acid) have been developed allowing binding of Escherichia coli cells and the elution of bound cells with high recoveries. These poly(acrylamide)-based continuous supermacroporous columns have been produced by radical
Ten patients, who had been treated according to the Malmo model for immune tolerance induction (ITI), were analysed regarding treatment with clotting factors and chemotherapy during the time period between inhibitor detection and ITI. Of the patients who were successfully rendered tolerant (n=6) all but one had received treatment with FVIII, either alone (n=1), or combined with cyclophosphamide (n
This chapter contains an outline of the Swedish social security system with a focus on sickness benefits in the social security and unemployment insurance. The Swedish legislator’s ambition has been to create parity between different forms of employment as well as between those who are self-employed and those who operate in different company structures. Legislative amendments in this area have mai
The most complete and realistic physiological data are derived from direct measurements during human experiments; however, they present some limitations such as ethical concerns, time and cost burden. Thermophysiological models are able to predict human thermal response in a wide range of environmental conditions, but their use is limited due to lack of validation. The aim of this work was to vali
Adaptive and flexible approaches based on implementing different measures as new information emerges have been proposed as a way of enabling robustness towards uncertain future climate change. However, the success of flexible approaches in practice depends on the stability of the relevant organizational landscapes. In this paper, we draw upon key insights from the institutional theories of organiz
The Gebel el Silsila Project is a multi-disciplinary Swedish mission dedicated to the study of the archaeological remains at Ancient Egypt’s largest sandstone quarry of Gebel el Silsila, Mountain of Chain, just north of Kom Ombo in the Aswan region. This paper presents a general summary of the epigraphical and archaeo-topographical survey of the largest quarry on the east bank – Qu
Obesity is a key factor for cardiovascular diseases and complications. Obesity is associated with hypertension, dyslipidemia and type II diabetes, which are the major predictors of cardiovascular disease in the future. It predisposes for atrial fibrillation, heart failure, sudden cardiac death, renal disease and ischemic stroke that are the main causes of cardiovascular hospitalization and mortali
Purpose - H2O, CO2 and CO are three main species in combustion systems which have high volume fractions. In addition, soot has strong absorption in the infrared band. Thus, H2O, CO2, CO and soot may take important roles in radiative heat transfer. To provide calculations with high accuracy, all of the participating media should be considered non-gray media. Thus, the purpose of this paper is to st
Dense urban morphologies further amplify extreme climate events due to the urban heat island phenomenon, rendering cities more vulnerable to extreme climate events. Here we develop a modelling framework using multi-scale climate and energy system models to assess the compound impact of future climate variations and urban densification on renewable energy integration for 18 European cities. We obse
