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Despite the plethora of information on (S)-selective amine transaminases, the (R)-selective ones are still not well-studied; only a few structures are known to date, and their substrate scope is limited, apart from a few stellar works in the field. Herein, the structure ofLuminiphilus syltensis(R)-selective amine transaminase is elucidated to facilitate engineering towards variants active on bulki
Aims: To evaluate the cost-effectiveness of bimekizumab, an inhibitor of IL-17F and IL-17A, against biologic and targeted synthetic disease-modifying antirheumatic drugs (DMARD) for psoriatic arthritis (PsA) from the Swedish healthcare system perspective. Materials and methods: A Markov model was developed to simulate the clinical pathway of biologic [b] DMARD-naïve or tumor necrosis factor inhibi
This paper examines European narratives regarding border externalisation within the context of the European Trust Fund for Africa (EUTF). It seeks to understand how the EU shapes its discourse on African migration, recommends solutions, and evaluates outcomes. As the latest and most comprehensive instrument for externalising migration management, the EUTF offers abundant source material to compreh
The highly infectious disease COVID-19 caused by the Betacoronavirus SARS-CoV-2 poses a severe threat to humanity and demands the redirection of scientific efforts and criteria to organized research projects. The international COVID19-NMR consortium seeks to provide such new approaches by gathering scientific expertise worldwide. In particular, making available viral proteins and RNAs will pave th
Pentachlorophenol (PCP) is a commonly found recalcitrant and toxic groundwater contaminant that resists degradation, bioaccumulates, and has a potential for long-range environmental transport. Taking proper actions to deal with the pollutant accounting for the life cycle consequences requires a better understanding of its behavior in the subsurface. We recognize the huge potential for enhancing de
Background: Most family studies on venous thromboembolism (VTE) have focused on first-degree relatives. Objectives: We took a pedigree-based approach and examined the risk of VTE and cardiometabolic disorders in offspring from extended pedigrees according to the densities of VTE in pedigrees. Methods: From the Swedish population, we identified a total of 482 185 pedigrees containing a mean of 14.2
Over the last 10,000 y, humans have manipulated fallow deer populations with varying outcomes. Persian fallow deer (Dama mesopotamica) are now endangered. European fallow deer (Dama dama) are globally widespread and are simultaneously considered wild, domestic, endangered, invasive and are even the national animal of Barbuda and Antigua. Despite their close association with people, there is no con
A search for events with a dark photon produced in association with a dark Higgs boson via rare decays of the standard model Z boson is presented, using 139 fb^{-1} of sqrt[s]=13 TeV proton-proton collision data recorded by the ATLAS detector at the Large Hadron Collider. The dark boson decays into a pair of dark photons, and at least two of the three dark photons must each decay into a pair of
A novel photoemission type of X-ray Beam Position Monitor (XBPM) for the 'white' undulator radiation is proposed. The XBPM employs beamline frontend fixed mask as a source of photocurrent signal. Signal spatial distribution and XBPM response were analyzed for various undulator radiation parameters.
This thesis seeks to answer the question of whether obligations to primary pandemic prevention and bio-risk management can be derived from the human right to health. The definition of the right to health in Article 12 of the International Covenant on Economic, Social, and Cultural Rights (ICESCR) was selected, as it is the broadest definition of the right to health in international human rights la
This thesis offers an overview of the relatively new family of Rosenbrock-Krylov numerical methods for ODEs. These methods are a further development of Rosenbrock methods, using a lower-dimension approximation of the Jacobian. The thesis gives the mathematical background to Rosenbrock-Krylov methods by first presenting Runge-Kutta methods and Rosenbrock methods, followed by the concept of Krylov s
There is a growing demand from policy makers for businesses to help close the consumer intention-action gap for sustainable product choice and strengthen the green economy. Moreover, there is increased interest from consumers in brands that are transparent about their environmental impact. This is not least the case for the focus sector of this study, food products, an industry responsible for aro
Background: The case company is a Swedish family-owned business, operating in the agri-food industry. Their philosophy is to develop, produce, and sell frozen products from the vegetable kingdom with a focus to be organic and convenient. The company has realized that the production layout and the material flow cause a lot of waste and have great potential for improvements regarding efficiency in p
This thesis aims to investigate the different mechanisms that Chinese companies in green industries used to acquire technological capabilities and how they changed over time. The thesis also aims to examine how the geographical pattern in outbound Chinese greenfield foreign direct investment has changed over time. By examining the inbound and outbound greenfield foreign direct investment pattern i
