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Essentials: Validated assays are required to precisely measure factor IX (FIX) activity in FIX products. N9-GP and two other FIX products were assessed in various coagulation assay systems at two sites. Large variations in FIX activity measurements were observed for N9-GP using some assays. One-stage and chromogenic assays accurately measuring FIX activity for N9-GP were identified. Summary: Backg

Purpose: We present clinical and laboratory data on 18 children from 12 hemophilia treatment centers in the United States, Canada, and Europe with the purpose of disseminating information regarding a recently recognized, potentially life-threatening complication of treatment in very young children with hemophilia B. Patients and Methods: Twelve hemophilia centers from the United States, Canada, an

Objectives: We compared the effectiveness of the Gold Standard Programme (a comprehensive smoking cessation intervention commonly used in Denmark) with other face-to-face smoking cessation programmes in Denmark after implementation in real life, and we identified factors associated with successful quitting. Design: Prospective cohort study. Setting: A total of 423 smoking cessation clinics from di

The current fossil-based economy must be transformed into a bio-based circular economy. A cornerstone of this transformation is the conversion of pulp and paper mills into lignocellulosic biorefineries that allow not only the production of pulp, paper, and electricity, but also novel biochemicals. Highly selective, electrifiable, and low-energy-consuming separation technologies will be key in the

Osteoporosis and osteoporosis related fractures are a major health care challenge both in Sweden and globally. The cost and suffering from osteoporosis are expected to increase since the population of elderly is increasing. Bone health can be affected by altered mineral homeostasis, which in its turn can be affected by reduced kidney function. However, the course of age-related decline in kidney f

Abstract: Noradrenaline (NA) metabolism tn the neocortex and hippocampus was examined in rats atl 1, 24, and 48 h following 15 min of reversible forebrain ischemia. As assessed by the ratio of accumulated 3,4‐dihydroxyphenylalanine (DOPA) to the tissue NA level after inhibition of DOPA decarboxylase, the NA turnover rates were markedly increased (120‐148% above the control) at 1 h postischemia in

Background: The optimal imaging follow-up after infrarenal EVAR is still undefined. The aim of this study was to analyze the outcome of a personalized follow-up program after infrarenal EVAR based on ultrasound AAA diameter measurements for low-risk patients. Methods: All consecutive patients followed-up locally after elective and acute infrarenal EVAR between 2010 and 2015 were retrospectively re

Denna avhandling handlar om hur arkitektur producerar normer genom hållbar stadsutveckling, från formulering av visioner och strategier till materialisering och design. Den handlar också om arkitekturens potentiella roll i att omförhandla och utmana den normativt utstakade vägen framåt, till förmån för alternativa förhållningssätt. Hållbar stadsutveckling beskrivs i avhandlingen som en typologi avArchitecture, planning and urban design are some of the professional practices that contribute to the spatial aspects of societal organization and enable everyday life to run smoothly. The urgent and intertwined challenges of climate change and social injustice have introduced new dimensions to these tasks, frequently framed as working towards ‘sustainable development.’ In this doctoral thesis, I

In recent years, FLASH irradiation has attracted significant interest in radiation research. Studies have shown that irradiation at ultra-high dose rates (FLASH) reduces the severity of toxicities in normal tissues compared to irradiation at conventional dose rates (CONV), as currently used in clinical practice. Most pre-clinical work is currently carried out using charged particle beams and the b

För en utförlig populärvetenskaplig sammanfattning, vänligen följ länken till höger på denna sidan. De svenska utbildningsmyndigheterna står inför ett seglivat problem. Lärare har under många år uttryckt missnöje över alltmer utbredda och genomgripande krav på dokumentation. En hel del dokumentation stjäl tid som annars skulle kunna läggas på elevers lärande och att utveckla undervisningen, lyder The Swedish education authorities are up against a tenacious problem. Teachers have for years expressed dissatisfaction over increasingly prolific and pervasive demands for documentation that hijacks time that could have been invested in pupils’ learning. Over the past 15 years different Swedish governments have sought to remedy this problem but to no avail. The ‘burden of documentation’, as it is

Bridging the pressure gap between surface science studies and industrial processes requires a combination of well-studied reactions, model systems as catalysts, and advanced techniques capable of detecting structural changes under realistic pressure conditions. Observations from such studies provide helpful insight into the present phases of the gas-surface boundary and transitions that happen dur

With the aim to understand prolonged and repeated marine anoxia after the Triassic-Jurassic massextinction event, a continuously cored, 338 metre thick succession of Rhaetian to Toarcian sediments was retrieved close to the village of Schandelah near Braunschweig (Lower Saxony, northern Germany). Here, preliminary biostratigraphical, lithological, sedimentological, geochemical, and geophysical bor

We recently reported that female patients with hypopituitarism receiving controlled thyroid and steroid hormone substitution, but without GH replacement, had a more than 2-fold increase in cardiovascular mortality compared to the general population. In the present study we investigated the incidence of cardiovascular disease as well as the prevalence of cardiovascular risk factors in 33 females wi

Due to the large number of electrons, solid state physics boils down to many-body approximations in which only selected types of collective excitations are taken into account, guided by the emergent properties of the material under study. In this thesis, the collective excitations of primary interest are electronic charge and spin fluctuations(plasmons and magnons) and nuclear charge fluctuations

Background: Recent declines of honeybees and simplifications of wild bee communities, at least partly attributed to changes of agricultural landscapes, have worried both the public and the scientific community. To understand how wild and managed bees respond to landscape structure it is essential to investigate their spatial use of foraging habitats. However, such studies are challenging since the

The thesis describes the development of a dynamic model of a microturbine system. The thesis is done in close cooperation with Turbec AB and the model is adjusted, tuned and verified against their microturbine T100. The microturbine unit consists of a compressor and a turbine connected on a single shaft to a high-speed generator. Moreover there is a combustion chamber, a recuperator and a gas/w

Den svenska staten bedriver affärsverksamhet via ett femtiotal företag av vilka staten äger minst 50% av företaget i 43 av fallen. År 2007 antog den svenska regeringen en rad nya riktlinjer gällande hållbarhetsrapportering för dessa företag. Dessa nya riktlinjer skulle tas i bruk från och med räkenskapsåret 2008. Hållbarhetsrapporteringen, dvs. den icke finansiella rapporteringen av dessa svenska In 2007 the Swedish government adopted a set of guidelines mandating all Swedish state-owned companies to conduct a non financial report i.e. a sustainability report that is to be independently verified. The sustainability report is to be in line with the internationally recognized Global Reporting Initiative framework (G3), a framework of guidelines for how to conduct sustainability reports. The

Jihadism has become a major topic in Western as well as non-western public debate. Many military groups have sprung up in late 20th and early 21st century, claiming legitimacy using jihad for a wide variety of causes ranging from Kashmir, Somalia, Bosnia, Chechnya, Afghanistan, Iraq, Syria, Yemen and Nigeria. This leads to the question whether Islamist fundamentalism has been successful in project

During the Devonian, 377 Ma ago, the Earth was impacted by a large celestial body, striking ground in the Siljan area in Dalarna, Sweden. The impact created what is today the largest confirmed impact structure in western Europe. Since its formation, the structure has however been heavily eroded, leaving no trace of the original crater. Today, it is instead recognizable due to the central plateau a