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Popular Abstract in Swedish Den äldre befolkningen i Sverige ökar i antal och med det ökar även antalet äldre med många sjukdomar som behöver läkemedel. Personer som är 75 år eller äldre utgör 9% av Sveriges befolkning men använder mer än 25% av alla läkemedel. I takt med att man blir äldre sker en del förändringar i kroppens funktioner som kan påverka effekten av läkemedel. De största förändringThe aim of this thesis was to investigate whether a structured and systematic approach on improving pharmacotherapy in the elderly (the LIMM-model) would lead to a more appropriate and accurate drug use in the elderly. The elderly use many drugs and are more prone to suffer from adverse drug reaction. It is therefore important to address the quality of their drug therapy. The first study presente

This thesis deals with the evaluation of measurements of water vapor transport and sorption in wood. It mainly concerns measurements of the weight response of a sample after a step change in relative humidity. The thesis consists of an introduction and eight papers. The eight papers have the following contents: 1. A description of the instrumentation and its performance characteristics. 2. Some f

Popular Abstract in Swedish I kroppen produceras varje dag ca 1 000 000 000 000 nya blodceller för att ersätta celler som förbrukats eller sorterats undan som odugliga. I toppen av hierarkin finns den hematopoietiska stamcellen, eller blodstamcellen, en cell med ett antal unika egenskaper: (i) Förmågan att dela sig och ge upphov till minst en ny blodstamcell (cell med samma egenskaper som modercelHOXB4 is one of 39 members of the homeobox (HOX) family, a family of transcription factors involved in embryonic development. Several HOX transcription factors, including HOXB4, are highly expressed in hematopoietic stem cells (HSCs) but are downregulated upon differentiation towards more mature progeny cells. Enforced expression of HOXB4 dramatically increases the regeneration of murine HSC follo

In a previous paper, we showed how classical ideas for dynamicprogramming in discrete networks can be adapted to hybrid systems. The approach is based on discretization of the continuous Bellman inequality which gives a lower bound on the optimal cost. The lower bound is maximized by linear programming to get an approximation of the optimal solution.In this paper, we apply ideas from infinite-dime

OBJECTIVE: To examine the endometrial expression pattern of messenger RNA (mRNA) for selected matrix metalloproteinases (MMP) and tissue inhibitor of metalloproteinases-1 (TIMP-1). DESIGN: Experimental study. SETTING: Department of Obstetrics and gynecology of the Palacky University Medical School and University Hospital, Olomouc, Czech Republic, Department of Obsterics and Gynecology, University

Refillable polyester bottles, for example polyethylene terephthalate (PET) bottles, are known to interact with chemicals. Aroma compounds from a product can be absorbed by the bottle material, remain after washing and remigrate when the bottle is reused, resulting in off-flavour of the new product. A certified reference material has recently been approved with which the chemical and sensory inertn

With Habermas' theory of communicative action as the starting point, a theoretical model is devised to investigate the act of creative writing as formulated in interviews made with students and teachers on a university study program me in creative writing. This article explores writers' work procedures in a communicative network of institutional and everyday practices, in the light of established

The contribution of this paper is a time-frequency domain speech presence detection method that classifies power bins in the time-frequency domain as containing speech or not. An initial decision rule is based on ratios between optimally time-smoothed signal-plus-noise periodograms and weighted noise periodogram estimates, obtained from minimum statistics as proposed by Martin [1]. The initial dec

The role of the 50S particle of Escherichia coli ribosome and its 23S rRNA in the refolding and subunit association of dimeric porcine heart cytoplasmic malate dehydrogenase (s-MDH) has been investigated. The self-reconstitution of s-MDH is governed by two parallel pathways representing the folding of the inactive monomeric and the dimeric intermediates. However, in the presence of these folding m

Botulinum neurotoxins (BoNTs) are exceptionally toxic proteins that cause paralysis, but are also extensively used as treatment for various medical conditions. Most BoNTs bind two receptors on neuronal cells, namely a ganglioside and a protein receptor. Differences in the sequence between the protein receptors from different species can impact the binding affinity and toxicity of the BoNTs. Here w

Populärvetenskaplig sammanfattning: I försök att producera kontinuerlig data över förändringar i jordens magnetfält använder man sig ofta av sjösediment. Magnetiska mineral, eroderade från den kringliggande berggrunden, förekommer ofta i sjöar. Koncentration av dem beror på hur rik bergrunden är på den typen av mineral, t.ex. magnetit. När de magnetiska mineralen faller till botten riktar de in siThe pseudo-Thellier technique was applied to recover relative palaeointensity (PT-RPI) estimates from four core sections, each 2 m in length, obtained from Lake Gościąż, Poland. The varve chronology from Lake Gościąż, originally constructed by Tomasz Goslar, was transferred to the sediment sequence. The chronology was extrapolated to cover the upper parts containing a less pronounced varve structu

Medeltidshandskrift 14, the so called Liber scole virginis, is the oldest existing song book of the Cathedral of Lund. It has been given much attention this year in connection with the 900th anniversary of the archdiocese of Denmark. The codicological analysis of this manuscript tells an interesting story about the development of the Marian cult in Lund.

As fossil based fuels are ever more proving to be an unsustainable energy-resource, it is of critical importance to find a new way to deliver power to the worlds vehicles in order to anticipate an ever-growing population and sustain economic growth. The task is complicated but very achievable from a technological point of view. It is however greatly overshadowed in complexity when it comes to educ

Based on extensive ethnographic fieldwork in Uzbekistan, this article looks at the way official state narratives are challenged by silent, unorganized, often unawares, gestures of resistance at the bottom of a society. Footing on a framework suggested by Scott’s definition of infrapolitics (2012), we propose to incorporate informal practices in a definition of informality that is more inclusive, a