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Background: Less than half of patients with major depressive disorder (MDD) respond to their first antidepressant trial. Our understanding of the underlying mechanisms of selective serotonin reuptake inhibitors (SSRIs) remains poor, and there is no reliable method of predicting treatment response. Methods: Thirty-seven MDD subjects and 41 healthy controls, somatically healthy and medication-free f
In this talk we report on first results from the NLO computation of Z production in association with five jets in hadron-hadron collisions. The results are obtained with the help of the numerical method, where apart from the phase space integration also the integration over the loop momentum is performed numerically. In addition we discuss several methods and techniques for the improvement of the
Atomic data, such as wavelengths, spectroscopic labels, broadening parameters and transition rates, are necessary for many applications, especially in plasma diagnostics, and for interpreting the spectra of distant astrophysical objects. The experiment with its limited resources is unlikely to ever be able to provide a complete dataset on any atomic system. Instead, the bulk of the data must be ca
In α-chymotrypsin-catalyzed acyl-transfer reactions in water the specificity of the enzyme (the nucleophile reactivity of amino acid amides) is correlated with the substrate hydrophobicity and increases as the hydrophobicity of the side chain of the amino acid amides is increased. In a low water system (4% H2O) bulky amino acid amides are less efficient nucleophiles. The specificity of α-chymotryp
The mechanics of a fascicle insertion into the skin by a mosquito of the type aedes aegypti has been studied experimentally using high-speed video (HSV) imaging, and analytically using a mathematical model. The fascicle is a polymeric microneedle composed of a ductile material, chitin. It has been proposed that the mosquito applies a non-conservative follower force component in addition to the Eul
Blood development relies on discrete stem and progenitor cell populations with unclear lineage relationships and distinct functional characteristics that change during ontogeny. In this issue of Cell Stem Cell, Beaudin et al. (2016) identify a hematopoietic stem cell population with fetal characteristics that is developmentally restricted yet capable of long-term multi-lineage reconstitution upon
Dataflow programming is a paradigm for describing stream processing algorithms in a manner that naturally exposes their concurrency and makes the resulting programs readily implementable on highly parallel architectures. Dataflow programs are graph structured, with nodes representing computational kernels that process the data flowing over the edges. There are two major families of languages for t
A 66-year-old man with type 2 diabetes on hemodialysis treatment was admitted due to poor glycemic control. His serum insulin level and the 125I-insulin binding rate were extremely high with an increased eosinophil count, although he did not have an allergic reaction to insulin or an elevation of specific IgE for human insulin. A Scatchard analysis revealed that the patient’s insulin antibodies ha
A wide divergence has been detected in the telomeric sequences among budding yeast species. Despite their length and homogeneity differences, all these yeast telomeric sequences show a conserved core which closely matches the consensus RAP1-binding sequence. We demonstrate that the RAP1 protein binds this sequence core, without involving the diverged sequences outside the core. in Saccharomyces ca
An increasingly common and effective method for the treatment of atherosclerotic disease in the coronary arteries is percutaneous transluminal coronary angioplasty (PTCA) and stenting. The stents are made of different metals. An increased rate of restenosis when using gold-plated stents has been shown. Contact allergy to gold is common in many countries. Recently, a study has shown an increased ra
We discuss how techniques from multiresolution analysis and phase space transforms can be exploited in solving a general class of evolution equations with limited smoothness. We have wave propagation in media of limited smoothness in mind. The frame that appears naturally in this context belongs to the family of frames of curvelets. The construction considered here implies a full-wave description
Various types of graph statistics for graphs and digraphs are presented as numerators of incomplete U-statistics, with symmetric and asymmetric kernels, respectively. Thus, asymptotic Poisson limits of these statistics are provided by using limit theorems for the sums of dissociated random variables. Several applications to statistical analysis of graphs are given
The conversion of sodium lactate to lactic acid with water-splitting electrodialysis was investigated. One way of reducing the power consumption is to add a conductive layer to the acid compartment. Doing this reduced the power consumption by almost 50% in a two-compartment cell, whereas the electric current efficiency was not affected at all. Three different solutions were treated in the electrod
There is in large parts of the world a demographic crisis. Due to the increase in life length and the drop inbirth rates, prospects are that much fewer people of working age will be available in the future to supportthose in retirement.Also Sweden faces a demographic challenge, implying that it will be necessary to make the Swedeswork more years. There is an obvious potential in the age range 65-7
The topic of the thesis is re-initialization of multistep methods for the solution of ordinary differential equations, in which there are frequent discontinuities in first or higher derivatives. There are self-starting algorithms to start or restart a multistep method. It is normally started by first using a one-step method and then increasing the order successively until the working order is reac
Introduction: Carpal tunnel syndrome (CTS) is a common condition especially for people with diabetes, obesity or women who are pregnant. Diagnosing CTS has primarily been performed using electroneuronography. In this thesis the aim was to use an advanced method of tractography to measure and evaluate diffusion tensor imaging (DTI) parameters between anatomical landmarks at the distal radioulnar jo
The aetiology of oral lichen lesions is obscure. In this study the frequency of contact allergy to gold in 83 patients with oral lichen lesions was compared with that in two control groups, comprising 319 age- and gender-matched patients with dermatitis selected from files and 83 clinically examined dermatitis patients. All patients were tested epicutaneously with gold sodium thiosulphate. The two
