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Objectives To assess the effects of interventions authorised by the European Medicines Agency (EMA) or the US Food and Drug Administration (FDA) for prevention of COVID-19 progression to severe disease in outpatients. Setting Outpatient treatment. Participants Participants with a diagnosis of COVID-19 and the associated SARS-CoV-2 virus irrespective of age, sex and comorbidities. Interventions Dru
Purpose: Internet-delivered cognitive behavioral therapies and lifestyle interventions are promising for reducing psychiatric symptoms in cancer survivors, but little is known about the contribution of specific treatment components to observed effects. A randomized factorial trial could allow for evaluation of the unique contribution of treatment components to overall treatment effects. The IN-FAC
Background: Leukemia incidence has increased in recent decades among European children, -suggesting that early-life environmental exposures play an important role in disease development. Objectives: We investigated the hypothesis that childhood susceptibility may increase as a result of in utero exposure to carcinogens and hormonally acting factors. Using cord blood samples from the NewGeneris coh
Human leukocyte antigen (HLA)-matched sibling donor hematopoietic stem cell transplantation (HSCT) is available for only approximately 30% patients needing HSCT. Use of alternative donors is associated with a high incidence and severity of graft-versus-host disease (GVHD). Here we report our experience with GVHD prophylaxis using pre-transplant rabbit antithymocyte globulin (rATG), in addition to
Sound frequencies are represented in the primary auditory cortex (PAC) in a tonotopic structure which can be measured using functional magnetic resonance imaging (fMRI). A previous study has investigated vowels [ɑ] and [i] and seen a correlation between the vowels’ activation and the activation of simple tones corresponding to the vowels’ formant frequencies. Other vowels have not yet been studiedSound frequencies are represented in the primary auditory cortex (PAC) in a tonotopic structure which can be measured using functional magnetic resonance imaging (fMRI). A previous study has investigated vowels[ъ]and [i]and seen a correlation between the vowels¶ activation and the activation of simple tones corresponding to the vowels¶ formant frequencies. Oth
Exposure to phthalates is widespread and especially early life stages represent a critical window of exposure. In the present study, we investigated the effect of prenatal exposure to phthalates on birth outcomes and weight development in early life. In 130 mother–child pairs, we estimated the association of concentrations of 13 phthalates in spot-urine samples collected during pregnancy and birth
BACKGROUND: The number of people with lifestyle-related diseases continues to increase worldwide. Improving lifestyle behavior with health literacy may be the key to address lifestyle-related diseases. The delivery of educational videos using mobile health (mHealth) services can replace the conventional way of educating individuals, and visualization can replace the provision of health checkup dat
BACKGROUND: It is estimated that global dementia rates will more than triple by 2050 and result in a staggering economic burden on families and societies. Dementia carries significant physical, psychological and social challenges for individuals and caregivers. Informal caregiving is common and increasing as more people with dementia are being cared for at home instead of in nursing homes. Caregiv
OBJECTIVE: In patients with chronic radicular pain, we aimed to evaluate subgroup differences in 1-yr response to transforaminal epidural steroid injection. DESIGN: In this longitudinal cohort study of 100 subjects, 170 transforaminal epidural steroid injections were performed for 1 yr. The sample was stratified by type of disc herniation (protrusion n = 57, extrusion n = 27), by location of disc
Objective: This study explores the effect of voice quality and competing speaker/-s on children’s performance in a passage comprehension task. Furthermore, it explores the interaction between passage comprehension and cognitive functioning. Methods: Forty-nine children (27 girls and 22 boys) with normal hearing (aged 7–12 years) participated. Passage comprehension was tested in six different liste
Background: The fixation of uncemented tibia components in total knee arthroplasty may rely on the bone quality of the tibia; however, no previous studies have shown convincing objective proof of this. Component migration is relevant as it has been shown to predict aseptic loosening. Methods: We performed 2-year follow-up of 92 patients who underwent total knee arthroplasty surgery with an uncemen
The conditions for necking are well defined through the theory of Hill [1]. These conditions are applied to elasto plastic linearly hardening Tresca.and v Mises materials for different hardening characteristics. The results suggest that necking developes for all hardening materials. Below a certain hardening the stresses normal to the necking region and just outside it decrease during the necking
Purpose: Elevated cardiac troponin levels have been shown to be associated with a poor prognosis under some intensive care conditions. This study investigated whether inclusion of high-sensitivity troponin T (hsTnT) increased the prognostic accuracy of the Simplified Acute Physiology Score (SAPS 3) for general intensive care unit (ICU) patients, cardiac arrest patients, or patients with a non-card
This paper presents measurements of charged-particle distributions sensitive to the properties of the underlying event in events containing a Z boson decaying into a muon pair. The data were obtained using the ATLAS detector at the LHC in proton–proton collisions at a centre-of-mass energy of 13 Te with an integrated luminosity of 3.2fb-1. Distributions of the charged-particle multiplicity and of
Purpose: To understand if physical therapy in addition to individualized psychiatric specialist treatment could aid sedentary patients with schizophrenia spectrum disorders or affective spectrum disorders to become more physically active and also to identify assessments suitable for measuring physical activity, physical function and movement motivation. Materials and methods: In a longitudinal, cl
Beer is one of the most popular drinks in the world. Foam is a unique characteristic of beer, contributing to mouthfeelings and visual perceptions. Therefore, it would be worthwhile to study the solution and interfacial properties ofbeer and assess them with regards to foam.The main aim of this thesis was to evaluate the main foam-promoting components of beer in terms of solution,interfacial prope
A search with the ATLAS detector is presented for the Standard Model Higgs boson produced by vector-boson fusion and decaying to a pair of bottom quarks, using 20.2 fb−1 of LHC proton-proton collision data at s=8 TeV. The signal is searched for as a resonance in the invariant mass distribution of a pair of jets containing b-hadrons in vector-boson-fusion candidate events. The yield is measured to
A total of 1280 80-year-old men in the community of Malmö were questioned about smoking habits and the occurrence of cardiovascular disease (CVD). After a careful medical and duplex ultrasound examination, four groups were selected for further studies: (1) no CVD, non-smokers: (2) no CVD, smokers: (3) CVD, smokers: (4) CVD, non-smokers. In total 122 individuals participated. The average tobacco co
ObjectiveImplementation of patient-reported outcome measures for patients with palliative care needs is characterized by both enablers and barriers. The ways in which healthcare professionals experience the use of assessment tools is important. Our aims were to explore factors contributing to or hindering patients with palliative care needs in assessing their symptoms with the Integrated Palliativ
Background: Macrophage migration inhibitory factor is a proinflammatory cytokine that has been associated with various psychiatric disorders. MicroRNA-451a can directly target macrophage migration inhibitory factor and downregulate its expression in cells. However, the role of macrophage migration inhibitory factor and microRNA-451a in psychiatric patients treated with psychotherapeutic interventi
