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Blood pressure (BP) is a heritable risk factor for cardiovascular disease. To investigate genetic associations with systolic BP (SBP), diastolic BP (DBP), mean arterial pressure (MAP), and pulse pressure (PP), we genotyped ∼50,000 SNPs in up to 87,736 individuals of European ancestry and combined these in a meta-analysis. We replicated findings in an independent set of 68,368 individuals of Europe

Renal cell cancer (RCC) incidence varies worldwide with a higher incidence in developed countries and lifestyle is likely to contribute to the development of this disease. We examined whether meat and fish consumption were related to the risk of RCC in the European Prospective Investigation into Cancer and Nutrition (EPIC). The analysis included 493,179 EPIC participants, recruited between 1992 an

Essential hypertension is a multifactorial disorder and is the main risk factor for renal and cardiovascular complications. The research on the genetics of hypertension has been frustrated by the small predictive value of the discovered genetic variants. The HYPERGENES Project investigated associations between genetic variants and essential hypertension pursuing a 2-stage study by recruiting cases

Impact of SBP vs. DBP decrement during orthostasis on cardiovascular events in hypertension is not clear.

The Ile148Met (rs738409, G-allele) in the patatin-like phospholipase domain-containing protein 3 gene (PNPLA3) associates with liver fat content and may lead to loss-of-function (hydrolysis) or gain-of-function (CoA-dependent lysophosphatidic acid acyltransferase) defects. PNPLA3 is up-regulated by dietary carbohydrates, and interactions between rs738409 and carbohydrates, and sugar and ω6:ω3-poly

This study investigated if copeptin is affected by high salt intake and whether any salt-induced changes in copeptin are related to the degree of salt sensitivity. The study was performed on 20 men and 19 women. In addition to meals containing 50 mmol NaCl daily, capsules containing 100 mmol NaCl and corresponding placebo capsules were administered during 4 weeks each, in random order. Measurement

OBJECTIVE: We assessed the relationship between pulse pressure and intermediate cardiovascular phenotypes in a middle-aged cohort with high prevalence of hypertension. BACKGROUND: It has been suggested that central pulse pressure (cPP) is a better predictor of cardiovascular outcome than peripheral pulse pressure (pPP), particularly in the elderly. Yet, it is unclear if cPP provides additional pro

The PR interval on the electrocardiogram reflects atrial and atrioventricular nodal conduction time. The PR interval is heritable, provides important information about arrhythmia risk, and has been suggested to differ among human races. Genome-wide association (GWA) studies have identified common genetic determinants of the PR interval in individuals of European and Asian ancestry, but there is a

OBJECTIVE:: The risk factor pattern underlying a parental history of myocardial infarction (MI) is incompletely understood. We examined whether a parental history of clinically verified early MI may promote development of insulin resistance, obesity and the metabolic syndrome (MetS). METHODS:: One hundred and seventy-four offspring to patients with clinically verified MI before 60 years of age i

Coronary heart disease (CHD) development is associated to a combination of lifestyle and genetic factors. A number of lifestyle risk factors is well defined, while genetic factors have not yet been well determined.

Genetic risk scores (GRSs) have been associated with coronary heart disease (CHD) in large studies. We asked whether expanding an established 27-variant GRS (GRS27) to a 50-variant GRS (GRS50) improved CHD prediction and whether GRSs are independent of self-reported family history of CHD.

We investigated causal effect of completed growth, measured by adult height, on coronary heart disease (CHD), stroke and cardiovascular traits, using instrumental variable (IV) Mendelian randomization meta-analysis.

BACKGROUND:: Exposure to second-hand smoke has been shown to be associated with increased cardiovascular mortality in several, but not all, epidemiologic studies. Our aim was to investigate the risk of circulatory death associated with exposure to second-hand smoke in never-smokers in a very large prospective study, the European Prospective Investigation into Cancer and Nutrition. A secondary aim

This study makes a numeric and visual comparison of two different multibeam echo sounding (MBES) surveys performed at the exact same location, in an effort to establish how reliable and comparable the vertical depth measurements are. The horizontal position uncertainty is not issued in this study. The analysis was performed on data delivered by two survey contractors, The Norwegian Coastal Admini

Uppsatsen har som syfte att redogöra för alkoholpolitiken som bedrivs och som har bedrivits i Sverige och dess förhållande till EU-rätten, samt att redogöra för den alkohol- och hälsopolitik EU bedriver. Utöver diskuteras den fria rörligheten och alkoholimport. Sverige har sedan länge haft lagar som syftar till att begränsa de problem som är förknippade med alkohol. De allra tidigaste lagarna fråThe main purpose of this essay is to discuss Swedish politics on the alcohol field, and its problems when it comes to the treaties of the EU. In addition, I also want to write about the alcohol and health policy of the EU. Sweden has since many hundred years had problems associated with alcohol. The earliest laws came during the 1500s and provided penalty for drunkenness. Gradually our law maker b

Strålbehandling kan användas för att behandla olika cancerdiagnoser. Man vill då kunna rikta strålningen mot tumören medan så lite frisk vävnad som möjligt bestrålas. Olika studier visar att för patienter som behandlas med strålbehandling för cancer i vänster bröst är förekomsten av och dödligheten i olika hjärtsjukdomar högre än för de som behandlas med strålbehandling för cancer i höger bröst. DPurpose: To evaluate the benefits of using respiratory gating for left-sided breast cancer in the form of dose-sparing and biological effects to the heart and to investigate the set-up deviations for patients treated with respiratory gating in order to find an optimal correction strategy for this group of patients. Materials and methods: Nineteen patients treated with respiratory gating for left-

The commercially important Atlantic bluefin tuna (Thunnus thynnus, ABFT) has recently returned to Nordic waters after being absent for half a century due to intense, unregulated overfishing and eventual stock collapse. The present study processed and explored big data obtained from Pop-off Satellite Archival Transmitters deployed on large (CFL 248 +/- 16 cm) ABFT (n =75) in the Skagerrak from 2017

Objectives: Patients with type 1 diabetes mellitus (T1DM) lack the portal/peripheral insulin gradient, which might diminish insulin stimulation of hepatic lipogenesis and protect against development of nonalcoholic fatty liver disease (NAFLD). We compared liver fat content and insulin sensitivity of hepatic glucose production and lipolysis between overweight T1DM patients and nondiabetic subjects.

Few epidemiological studies have examined the association between dietary trans fatty acids and weight gain, and the evidence remains inconsistent. The main objective of the study was to investigate the prospective association between biomarker of industrial trans fatty acids and change in weight within the large study European Prospective Investigation into Cancer and Nutrition (EPIC) cohort.