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In families screened for mutations in the BRCA1 or BRCA2 genes and found to have a segregating mutation the breast cancer risk for women shown not to carry the family-specific mutation might be at above "average" risk. We assessed the risk of breast cancer in a clinic based cohort of 725 female proven noncarriers in 239 BRCA1 and BRCA2 families compared with birth-matched controls from the Danish
Mutations in the BRCA1 and BRCA2 genes significantly contribute to hereditary breast cancer and ovarian cancer, but the phenotypic effect from different mutations is insufficiently recognized. We used a western Danish clinic-based cohort of 299 BRCA families to study the female cancer risk in mutation carriers and their untested first-degree relatives. Founder mutations were characterized and the
Identification of Lynch syndrome tumors is challenging. This relates particularly to MSH6-associated cases, which show reduced penetrance of colorectal cancer and a higher age at diagnosis. We recorded the clinical and morphologic features of 52 MSH6-associated colorectal cancers in comparison with MLH1/MSH2-mutant tumors and sporadic mismatch repair-deficient cancers. In the MSH6 subset, we confi
Examensarbetet har gjorts på Nolato MediTech AB i Lomma via avdelning för Industriell produktion på Lunds Tekniska Högskola. Syftet har varit att analysera flödet från att produkt lämnar maskin tills den lämnar fabriken, identifiera problem och hitta eventuella lösningar. Bakgrunden till examensarbetet är att Nolato MediTech AB verkar inom medicinteknik-branschen som en kontraktstillverkare där tiThe master thesis has been performed at Nolato MediTech AB in Lomma through the Division of Production and Materials Engineering at Lund University. The purpose of the master thesis has been to analyze the internal flow of products from departure from the machine until the departure from the factory, identify problems and present solutions. The background of the thesis is that Nolato MediTech AB i
Uppsatsen har som syfte att redogöra för alkoholpolitiken som bedrivs och som har bedrivits i Sverige och dess förhållande till EU-rätten, samt att redogöra för den alkohol- och hälsopolitik EU bedriver. Utöver diskuteras den fria rörligheten och alkoholimport. Sverige har sedan länge haft lagar som syftar till att begränsa de problem som är förknippade med alkohol. De allra tidigaste lagarna fråThe main purpose of this essay is to discuss Swedish politics on the alcohol field, and its problems when it comes to the treaties of the EU. In addition, I also want to write about the alcohol and health policy of the EU. Sweden has since many hundred years had problems associated with alcohol. The earliest laws came during the 1500s and provided penalty for drunkenness. Gradually our law maker b
The aim of this thesis is to give a detailed account of migrant entrepreneurs in Malmö, their daily patterns, their unique experiences, the distinct strategies they develop, the challenges they face, and their relationship with ‘regulation and ‘advice’ organizations. In addition, unique ways of ‘making’ a restaurant via food and other material items are discussed and illustrated. It is also underl
Uppsatsen kommer att undersöka policydokumentet Partnerskapet för rörlighet mellan Marocko, Europeiska Unionen (EU) och EU:s medlemsstater som ingicks 2013. Uppsatsen ämnar att utöka förståelsen för hur Sub-Sahariska migranter i Marocko representeras som ett problem i Partnerskapet för rörlighet av EU och EU:s medlemsstater och vilken innebörd det har för deras möjligheter att migrera till Europa.This essay will analyse the Mobility Partnership policy between Morocco, the European Union (EU) and its Member States that was signed in 2013. The essay is intended at increasing the knowledge for how sub-Saharan migrants in Morocco are represented as a problem in the Mobility Partnership by Morocco, EU and its Member States and which significance it has for their possibilities to migrate to Euro
BACKGROUND: Multidrug resistant Acinetobacter baumannii remains a global concern with its ability to adhere, disperse and sustain in areas involving suboptimal infection control measures, particularly in war areas. In this study we aimed to evaluate the susceptibility profiles, molecular epidemiology and pathogenesis of A. baumannii isolates from conflict zones in Ukraine.METHODS: A. baumannii wou
This essay investigates the impact of classroom gender composition on the mental health of adolescent students. Using data from the Health Behaviours of School-aged Children survey in the Czech Republic, we exploit idiosyncratic classroom variation in the gender composition within the same schools across different grades. We find that a higher proportion of female peers in the classroom has a detr
Patent foramen ovale (PFO) is present in approximately 25% of the general population. PFO is characterized by intermittent shunting of blood from the right to the left atrium, especially in the context of increased right-sided filling pressures, with risk of paradoxical embolism. We describe a 69-year-old woman presenting with acute chest pain, severe dyspnoea, and acute inferolateral ST-segment e
Herein I will provide a brief overview of artificial receptors with emphasis on molecularly imprinted polymers (MIPs) and their applications. Alternative techniques to produce artificial receptors such as in silico designed and modelled polymers as well as different receptors designed using libraries of more or less natural composition will also be mentioned. Examples of these include aptamers and
The phosphatase and actin regulator 1 (PHACTR1) locus is a very commonly identified hit in genome-wide association studies investigating coronary artery disease and myocardial infarction (MI). However, the function of PHACTR1 in the heart is still unknown. We characterized the mechanisms regulating Phactr1 expression in the heart, used adenoviral gene delivery to investigate the effects of Phactr1
Context:A common genetic variant (rs10423928, A-allele) in the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) is associated with decreased insulin secretion. Glucose-dependent insulinotropic polypeptide is secreted after food consumption and gipr knockout mice fed a high-fat diet are protected against obesity and disturbances in glucose homeostasis. Objective:Our objective was
Aim: Colorectal cancer is the third most common form of cancer in the industrial countries. Due to advances regarding the treatments, primarily development of improved surgical methods and the ability to make the earlier diagnosis, the mortality has remained constant during the past decades even though the incidence in fact has increased. To improve chemotherapy and enable personalised treatment,
Background The hereditary non-polyposis colorectal cancer (HNPCC) subset of tumours can broadly be divided into tumours caused by an underlying mismatch-repair gene mutation, referred to as Lynch syndrome, and those that develop in families with similar patterns of heredity but without disease-predisposing germline mismatch repair mutations, referred to as familial colorectal cancer type X (FCCTX)
Background: Immunohistochemical staining for mismatch repair proteins is efficient and widely used to identify mismatch repair defective tumors. The tumors typically show uniform and widespread loss of MMR protein staining. We identified and characterized colorectal cancers with alternative, heterogenous mismatch repair protein staining in order to delineate expression patterns and underlying mech
Genetic markers can be used as instrumental variables, in an analogous way to randomization in a clinical trial, to estimate the causal relationship between a phenotype and an outcome variable. Our purpose is to extend the existing methods for such Mendelian randomization studies to the context of multiple genetic markers measured in multiple studies, based on the analysis of individual participan
Background: Epidemiological studies have shown considerable heritability of blood pressure, thus suggesting a role for genetic factors. Previous studies have shown an association of a single nucleotide polymorphism rs5068 in the NPPA locus gene with higher levels of circulating atrial natriuretic peptide as well as with lower intra individual blood pressure, but up to date, no association between
Background: Dietary fiber, carbohydrate quality and quantity are associated with mortality risk in the general population. Whether this is also the case among diabetes patients is unknown. Objective: To assess the associations of dietary fiber, glycemic load, glycemic index, carbohydrate, sugar, and starch intake with mortality risk in individuals with diabetes. Methods: This study was a prospecti
