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Children with hemophilia have a significantly higher risk of intracranial hemorrhage (ICH) compared to the normal population. Prophylaxis reduces the risk of ICH and earlier initiation of prophylaxis may now be feasible, especially in hemophilia A (HA). The aim of the study is to explore the potential for preventing ICH by earlier start of prophylaxis by assessing the natural course of ICH before
Principal component analysis (PCA) and k-nearest neighbor (kNN) can be applied to extract and compare activity distributions from electrocorticogram (ECoG) signals across recorded neural activity. Here, we present a protocol for recording ECoG activity from the neocortex of rats and applying PCA and kNN on the recorded data. This protocol allows for comparison between different types of cortical a
Lung imaging in mouse disease models is crucial for the assessment of the severity of airway disease but remains challenging due to the small size and the high porosity of the organ. Synchrotron inline free-propagation phase-contrast computed tomography (CT) with its intrinsic high soft-tissue contrast provides the necessary sensitivity and spatial resolution to analyse the mouse lung structure in
Identifying patients at high risk of bone fracture is an important task. The clinical risk assessment, based on measurements of bone mass, correlates with strength but not toughness and is insufficient for reliable identification of high-risk patients. Starting from non-linear fracture mechanics, we hypothesise that reduced bone tissue fracture toughness and characteristic length, possibly in comb
Background: In this study, we further developed an artificial intelligence (AI)-based method for the detection and quantification of tumours in the prostate, lymph nodes and bone in prostate-specific membrane antigen (PSMA)-targeting positron emission tomography with computed tomography (PET–CT) images. Methods: A total of 1064 [18F]PSMA-1007 PET–CT scans were used (approximately twice as many com
Measurements of the stable carbon isotope ratio in methane (δ13C-CH4) are used in determining the source of CH4 emissions on local, regional, and global scales. To achieve the required level of data comparability for atmospheric monitoring networks, accurate gas reference materials of δ13C-CH4 in air are required with high levels of reproducibility. We describe a method to determine the δ13C-CH4 o
Background and aims: Heart transplantation is the preferred treatment for selected patients with end stage heart failure. Kidney function often declines after heart transplantation. Sodium-glucose cotransporter 2 inhibitors (SGLT2i) slow the decline in eGFR in different populations. However, the effect of SGLT2i on kidney function in heart transplant recipients is unknown. Methods: The Dapaglifloz
This research presents a quest for the definition of “foreign direct investment” under the EU framework for FDI screening by the Member States, established by Regulation 2019/452 based on public policy and security. This Thesis argues that the scope of the current Regulation, excluding “indirect” FDI made by foreign investors via an EU subsidiary, coupled with the lenient, non-compulsory nature of
The global need to take urgent action to address climate change presents the German automotive industry with its biggest transformation in history. While environmental targets are being set, the importance of leadership in the transformation process has so far received little attention. Using a Causal Model of Organizational Performance and Change, and the Transformational Leadership framework, th
With the ambitious objectives of the European Green Deal, offshore wind energy is especially an important sector of Europe’s renewable energy strategy. This thesis aims to clarify the intricate legal and regulatory structures governing offshore wind projects, with a particular focus on the permitting process in Denmark and Sweden, and to what extent it is aligned with the Renewable Energy Directiv
Socio-environmental crisis are also crisis of imagination. In the city of Taranto, the heavy industry has had devastating socio-environmental effects, and the dominant narrative still considers environmental and social sustainability as a double bind. Consequently, to this date there is no sign that anticipate a solution to the socio-environmental crisis. By means of 3 horizons framework, this wor
The increase in female labour force participation rate can be considered as the most significant labour market trend taken place over the last 120 years in the United States. However, despite the drastic increase, women’s labour participation has stagnated since the mid-1990s. There is a lack of research about the social aspects of FLFP including how anti-egalitarian views reinforced by media repr
Title: Exploring Coordination Mechanisms and Product Characteristics for Food Waste Reduction Principles: A Case Study in Physical Distribution Author: Zacharias Samuelsson Thesis supervisor: Eva Berg, Faculty of Engineering at Lund University Thesis Purpose: Identify food waste causes in a global distribution network and develop an improvement proposal for minimizing food waste. Method: This
I present a theoretical model for competitive interaction between schools and grade inflation. To test the model, I estimate the effect of competition on grade inflation in Swedish upper secondary schools using data from all schools in the years 2012-2015. To solve the endogeneity problem of competition, I use Instrumental Variable estimation with Fixed Effects. I use the sudden shutdown of 17 sch
The global food system, population growth, increased wealth, shifting diets and an overall larger demand for processed food, meat and dairy, has led to increased pressure on land, water and energy. The environmental implications of this have taken part in the establishment of international institutions which aims to regulate agriculture production methods, and thereby reduce these adverse impacts.
Reaching the 1.5°C target of the Paris Agreement not only requires ambitious goals from national governments, but also the active participation of local municipalities. It is in cities where climate actions need to be implemented to reduce greenhouse gas emissions and reach the international and national climate goals. While the importance of cities and their participation in networks has been wel
The aim of this study is to investigate how John Marsden’s Tomorrow, when the war began (1993) could be used for reading-between-the-lines practice in the English language classroom. It answers questions relating to how reading between the lines can be understood in relation to Grice’s cooperative principle, the effects of implicature in the text and how teachers can use this information to facili
