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This case study investigates the development of subject-specific literacy in Physical Education and Health (PEH) for second language (L2) learners within a Swedish secondary school context. Integrating Systemic Functional Linguistics (SFL) and Legitimation Code Theory (LCT), the study introduces the concept of embodied cohesion to analyze how meaning is constructed across verbal, graphic, and phys
Background: Ambulatory oxygen therapy can be used to treat exertional hypoxaemia during daily life activities in people with fibrotic interstitial lung disease (ILD). However, evidence for its efficacy is scarce. This trial aimed to compare the effects of ambulatory oxygen with ambulatory air on physical activity in daily life over 6 months in people with fibrotic ILD and isolated exertional hypox
Case study research plays an important role for social and political scientists working within the qualitative tradition, with the field of international relations (IR) being no exception. This article provides methodological reflections on the challenges of investigating ‘elusive’ cases within the global governance domain of IR. Taking stock of my experience of studying global multi-stakeholder p
Purpose: To investigate factors guiding follow-up imaging after hospital discharge in atraumatic intracerebral hemorrhage (ICH) across large European academic centers and compare decision-making patterns using a standardized approach. Methods: Expert neuroradiologists from nine European centers in eight countries detailed their follow-up algorithms for deep and lobar ICH, specifying (1) patient-re
The glymphatic system facilitates cerebrospinal fluid (CSF)-interstitial fluid exchange and plays a key role in solute clearance and neurophysiological homeostasis. While dysfunction of this system has been shown in traumatic brain injury, stroke, meningitis, idiopathic normal pressure hydrocephalus and neurodegenerative diseases, direct measurement of glymphatic transport in humans remains elusiv
Abstract INTRODUCTION Countries have varying, limited healthcare budgets for emerging disease-modifying therapies. Cost-effectiveness analysis, combined with country-level cost-effectiveness thresholds, can be used to estimate value-based prices (VBPs) for lecanemab and donanemab across 174 countries. METHODS The cost-effectiveness of lecanemab and donanemab was estimated using incremental cost an
Neurofilament light chain (NfL) is a promising biomarker of axonal injury across acute and chronic neurodegeneration, which can improve drug discovery and disease monitoring models. Traditional in vivo animal models cannot fully mimic human pathophysiology of neurodegenerative diseases (NDDs), but in vitro models based on human cells solve this problem, reducing the time and cost of drug testing.
OBJECTIVE: Fatigue is a common and debilitating non-motor symptom of Parkinson's disease (PD), arising from a complex interplaying underlying factors. While mental health and sleep are well-established evidence regarding motor symptoms, balance, gait, and cognition remain inconsistent. By explicitly examining multiple symptom domains within the same cohort, we aimed to identify which factors are m
Standardized Care Pathway (SCP) for patients presenting with macroscopic haematuria was introduced in Sweden in 2015. In contrast to neighbouring countries, the Swedish model includes all patients with macroscopic haematuria above the age of 50, notwithstanding obvious causes. The aim of this study was to characterize the patients referred within the SCP and the presence of acute cystitis.All pati
Background: Children and adolescents with autism spectrum disorder (ASD) are generally more sedentary and engage less in physical activity (PA) than their peers. Despite increasing evidence of benefits, practical guidance on implementing adapted PA programs in real-world settings remains limited. This study aimed to document iterative adaptations, implementation processes, and participant experi
The Swedish public library was founded in the years when the society in Sweden went from being a society of agriculture to industrialism. Modernism was sweeping over the country, everything was possible, which influenced the new society that was built. Now Sweden was going to be a true democracy with responsible and empathic citizens. One of the main tools in this process was to educate people, to
This study presents a digital solution for inducing visually-induced motion sickness (VIMS) using a head-mounted display (HMD) in a virtual environment. By digitally replicating off vertical axis rotation by adopting the Epley Omniax Chair, we induce sensory conflicts between the visual and vestibular systems through rotational vection, alongside optokinetic stimulation inspired by the Optoki-neti
Interpretation of data from faint dwarf galaxies is made challenging by observations limited to only the brightest stars. We present a major improvement to tackle this challenge by undertaking zoomed cosmological simulations that resolve the evolution of all individual stars more massive than 0.5 M⊙, thereby explicitly tracking all observable stars for the Hubble time. For the first time, we predi
Studying the behavior of multiple participants using networked eye-tracking setups is of increasing interest to researchers. However, to conduct such studies, researchers have had to create complicated ad hoc solutions for streaming gaze over a local network. Here we present TittaLSL, a toolbox that enables creating networked multi-participant experiments using Tobii eye trackers with minimal prog
Developing accurate large-scale drought prediction models is challenging due to the complex temporal and spatial correlation patterns that govern drought dynamics, as well as the compounding effects of anthropogenic activities and global climate change. Although recent advances in deep learning have yielded effective drought prediction models, many struggle to fully capture the heterogeneous spati
Background: In Sweden, dental care for children and adolescents, including specialist orthodontic treatment, is publicly funded. This study aims to analyze the impact of sociodemographic factors on the distribution of publicly funded specialist orthodontic treatment in a mid-sized Swedish region. Methods: A registry-based cohort study was conducted in Region Östergötland, including individuals bor
Phlorotannins, the polyphenols mostly found in brown seaweeds, have attracted high attention from the pharmaceutical industry in recent years due to their antioxidant, antibacterial, and anti-inflammatory activities. These properties make them desirable to be utilized in a wide range of therapeutics. Despite their importance, several challenges make their extractability and identification complex,
Objectives: This is a protocol for a Cochrane Review (intervention). The objectives are as follows:. To assess the effects of higher − compared with standard − initial doses of surfactant in high-risk preterm infants and preterm infants with respiratory distress syndrome.
Children with hemophilia have a significantly higher risk of intracranial hemorrhage (ICH) compared to the normal population. Prophylaxis reduces the risk of ICH and earlier initiation of prophylaxis may now be feasible, especially in hemophilia A (HA). The aim of the study is to explore the potential for preventing ICH by earlier start of prophylaxis by assessing the natural course of ICH before
Principal component analysis (PCA) and k-nearest neighbor (kNN) can be applied to extract and compare activity distributions from electrocorticogram (ECoG) signals across recorded neural activity. Here, we present a protocol for recording ECoG activity from the neocortex of rats and applying PCA and kNN on the recorded data. This protocol allows for comparison between different types of cortical a
