Search results

Effects of hydrogen bonding and the axial ligand interaction on the B800 band in two LH2 complexes Rhodopseudomonas (Rps.) acidophila and Rhodospirillum (Rs.) molischianum have been theo retically investigated by using density functional theory. The local electrostatic environment of the B800 bacteriochlorophyll is simulated as an atomic charge field consisting of the pigments in the protomer unit

Leukotriene ( LT) A(4) hydrolase is a bifunctional zinc metalloenzyme, which converts LTA(4) into the neutrophil chemoattractant LTB4 and also exhibits an anion-dependent aminopeptidase activity. In the x-ray crystal structure of LTA(4) hydrolase, Arg(563) and Lys(565) are found at the entrance of the active center. Here we report that replacement of Arg(563), but not Lys(565), leads to complete a

M1 aminopeptidases comprise a large family of biologically important zinc enzymes. We show that peptide turnover by the M1 prototype, leukotriene A4 hydrolase/aminopeptidase, involves a shift in substrate position associated with exchange of zinc coordinating groups, while maintaining the overall coordination geometry. The transition state is stabilized by residues conserved among M1 members and i

Rat adipocyte cGMP-inhibited cAMP phosphodiesterase (cGI-PDE) appears to be dually regulated in intact cells by serine phosphorylations induced by isoprenaline and insulin, respectively (Degerman, E., Smith, C. J., Tornqvist, H., Vasta, V., Belfrage, P., and Manganiello, V. C. (1990) Proc. Natl. Acad. Sci. U.S.A. 87, 533-537; Smith, C. J., Vasta, V., Degerman, E., Belfrage, P., and Manganiello, V.

This introduction positions the special issue Alevi Pasts Contested as an intervention in the ongoing effort to rethink Alevi tradition by foregrounding the plurality, dynamism, and situated character of imaginations related to the history of the Alevis. It argues that epistemological frameworks shaped by Orientalist and nationalist paradigms, as well as ethnographic and diaspora research, have pr

The Amazon Basin is a unique region to study atmospheric aerosols, given their relevance for the regional hydrological cycle and the large uncertainty of their sources. Multi-year datasets are crucial when contrasting periods of natural conditions and periods influenced by anthropogenic emissions. In the wet season, biogenic sources and processes prevail, and the Amazonian atmospheric composition

The global nature of businesses has increased the geographical dispersion of operations and has made the location decision an important strategic perspective for manufacturing firms. The consensus view is that three major plant location factors must be kept in mind: (1) access to low-cost manufacturing, (2) proximity to market, and (3) access to development competences. Two options for changing th

In the past two decades, the eddy covariance technique has been used for an increasing number of methane flux studies at an ecosystem scale. Previously, most of these studies used a closed path setup with a tunable diode laser spectrometer (TDL). Although this method worked well, the TDL has to be calibrated regularly and cooled with liquid nitrogen or a cryogenic system, which limits its use in r

Wildfires are a natural disturbance shaping boreal forests, but their effects on soil microbial communities and biogeochemical cycling remain unclear, particularly in Fennoscandia. We investigated the impact of fire severity and post-fire management on the soil microbial community two years after a boreal wildfire in Sweden. We quantified growth rates of bacteria, saprotrophic fungi (SF), ectomyco

Bacteria and humans have co-evolved since their common existence. They have thereby developed very specific defence and target mechanisms against one another. Understanding the complex biomolecular processes behind these interactions can be of great use for developing treatments against bacterial diseases. The aim of this thesis project was to verify, and introduce a model for understanding, the i

Lund University conducts active fundraising to increase philanthropic funding for the university's activities. Target groups are private foundations, companies, organizations and individuals. The Development Office is the central hub for generating these types of donations and gifts. Our overall goal with the operation is that Lund University and our donors, in their own unique way, should be able

Particle formation events were analysed from aerosol number size distribution data collected at a background station in southern Sweden between February 2001 and May 2004. Events occurred on about 36% of all days and were favoured by high global radiation values. The clearest events (class I, 20% of all days) were observed when the formation rate of activated hypothetical clusters around 1 nm diam

-Reduced arterial compliance precedes changes in blood pressure, which may be mediated through alterations in vessel wall matrix composition. We investigated the effect of the collagen type I-alpha1 gene (COL1A1) +2046G>T polymorphism on arterial compliance in healthy individuals. We recruited 489 subjects (251 men and 238 women; mean age, 22.6+/-1.6 years). COL1A1 genotypes were determined using