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Combining CRISPR-Cas9 and brain imaging to study the link from genes to molecules to networks

Receptors, transporters, and ion channels are important targets for therapy development in neurological diseases, but their mechanistic role in pathogenesis is often poorly understood. Gene editing and in vivo imaging approaches will help to identify the molecular and functional role of these targets and the consequence of their regional dysfunction on the whole-brain level. We combine CRISPR-Cas9

Domain Decomposition for Non-smooth (in Particular TV) Minimization

Domain decomposition is one of the most efficient techniques to derive efficient methods for large-scale problems. In this chapter such decomposition methods for the minimization of the total variation are discussed. We differ between approaches which directly tackle the (primal) total variation minimization and approaches which deal with their predual formulation. Thereby we mainly concentrate on

Breathe : Bridging the Personal and The Planetary through Augmented-Reality Experiences

As societies worldwide seek to grapple with the scope and consequences of the climate emergency, artists, museums, and art spaces have a growing role in developing the repertoire of climate narratives, images, and stories. This chapter presents the creative process and lessons of an augmented reality experience that highlights the fundamental interdependence between the human body and the biospher

Unlocking the impact of the CRPD on Swedish mental health law

The Convention on the Rights of Persons with Disabilities (CRPD) sets out a new vision for mental health care with equality and self-determination as its core standards. The CRPD fundamentally challenges long-standing practices in Sweden including the use of involuntary hospitalization, treatment without consent, and the use of restraints. This article discusses the impact of this new vision on Sw

Praxis or Talk about Praxis? The Concept of Praxis in Ecclesiology

Churches are in crisis. The turn to praxis in ecclesiology appears to attend to the current crisis; yet, the appearance might be deceptive. Since post-liberal ecclesiologies – such as John Milbank’s – consider neither quantitative-empirical nor qualitative-empirical accounts of concrete churches, the turn might be assessed as a turn to talk about praxis instead of a turn to praxis. Confronting Mil