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The ubiquitin (Ub) kinase-ligase pair PINK1-PRKN mediates the degradation of damaged mitochondria by macroautophagy/autophagy (mitophagy). PINK1 surveils mitochondria and upon stress accumulates on the mitochondrial surface where it phosphorylates serine 65 of Ub to activate PRKN and to drive mitochondrial turnover. While loss of either PINK1 or PRKN is genetically linked to Parkinson disease (PD)

We study the geometric significance of Leinster’s notion of magnitude for a compact metric space. For a smooth, compact domain X in an odd-dimensional Euclidean space, we show that the asymptotic expansion of the function MX(R) = Mag(R·X) at R = ∞ determines the Willmore energy of the boundary ∂X. This disproves the Leinster-Willerton conjecture for a compact convex body in odd dimensions.

Here, an acoustophoresis chip is presented that is capable of separating cancer cells from white blood cells (WBCs) and subsequently concentrating the recovered cells in the same chip. The chip utilizes ultrasound standing waves in two dimensions to pre-align, separate and concentrate the cells. 92% of the cancer cells could be recovered while keeping the contamination level of WBCs to only 0.6%.

With the help of sermon manuscripts from the time of the Spanish flu, held within the Church of Sweden, new light is shed on sermons held in the beginning of the Covid-19 pandemic. The comparison shows, among other things, that a shift has been made in how God is portrayed. It also points to some challenging questions about suffering, hope and the role of eternity in preaching today.

Light microscopy has been a favorite tool of biological studies for almost a century, recently producing detailed images with exquisite molecular specificity achieving spatial resolution at nanoscale. However, light microscopy is insufficient to provide chemical information as a standalone technique. An increasing amount of evidence demonstrates that optical photothermal infrared microspectroscopy

To study the role of the mossy fiber afferents to the cerebellum in classical eye-blink conditioning, in particular the timing of the conditioned responses, we compared the effects of varying a peripheral conditioned stimulus with the effects of corresponding variations of direct stimulation of the mossy fibers. In one set of experiments, decerebrate ferrets were trained in a Pavlovian eye-blink c

Cloud computing has emerged as a key technology in the latest decade and continues to be applied to manage the computing needs of new domains. As a result, the requirements on predictable behavior in the cloud increase, thus the hosted applications need to be recognized as both fault-tolerant and responsive even under difficult conditions.In this thesis, new modeling methods and decision-making st

Muhammad 'Abduh (1849-1905) was one of the key thinkers and reformers of modern Islam who has influenced both liberal and fundamentalist Muslims today. 'Abdul-Baha (1844-1921) was the son of Baha'ullah (1817-1892), the founder of the Baha'i Faith; a new religion which began as a messianic movement in Shii Islam, before it departed from Islam. Oliver Scharbrodt offers an innovative and radically ne

Malignant brain tumors constitute a disaster in the lives of patients, either in the form of extremely low survival in glioblastoma, or the serious long-term adverse effects of therapy in medulloblastoma. These two tumor types represent the most common malignant brain entities in adults and children, respectively. Ever since the early 2000’s, no major improvement of patient outcomes occurred. Immu

Background: Neuropsychiatric symptoms (NPS) are common in individuals with Alzheimer’s disease (AD) dementia, but substantial heterogeneity exists in the manifestation of NPS. Sex differences may explain this clinical variability. We aimed to investigate the sex differences in the prevalence and severity of NPS in AD dementia. Methods: Literature searches were conducted in Embase, MEDLINE/PubMed,

The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and

Iraqi diaspora mobilization and the future development of Iraq – authored by Dr. Oula Kadhum, explores Iraqi diaspora mobilization before and after the 2003 invasion and fall of the regime of Saddam Hussein. It looks at the ways members of the diaspora sought to help in the rebuilding of their country of origin, at both the elite and grassroots levels, as well as investigating changes over time. I

I describe changes in the social structure of the Swedish workforce over the long term. Occupational coding from nine full count censuses from 1880 until 1990 and 2001-2016 occupational registers is aligned to comprehensively map social stratification for birth cohorts born 1820-1985. We show occupational upgrading for working women and men over the past 150 years. The male andfemale workforce con

IntroductionMilitary tasks place considerable physiological demands on the soldier. It is therefore important to know the energy expenditure of soldiers while solving tasks in different environments. The purpose of this study was to describe the cardiorespiratory demands of certain movements and activities on ground combat soldiers during military field operations using body sensors and simulated

Combining position and force control is highly desirable in many robot applications. Many years of extensive research has resulted in a number of promising control approaches, but often too much engineering effort is required in order to evaluate a low level (high performance) control scheme on a real manipulator. The new control system we have obtained has two main advantages: first it provides a