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MEK1/2 inhibitor U0126 but not endothelin receptor antagonist clazosentan reduces upregulation of cerebrovascular contractile receptors and delayed cerebral ischemia, and improves outcome after subarachnoid hemorrhage in rats.

Cerebral vasospasm and late cerebral ischemia (LCI) remain leading causes of mortality in patients experiencing a subarachnoid hemorrhage (SAH). This occurs typically 3 to 4 days after the initial bleeding and peaks at 5 to 7 days. The underlying pathophysiology is still poorly understood. Because SAH is associated with elevated levels of endothelin-1 (ET-1), focus has been on counteracting endoth

Adsorption of trimethyl phosphate and triethyl phosphate on dry and water pre-covered hematite, maghemite, and goethite nanoparticles

Adsorption of trimethyl phosphate (TMP) and triethyl phosphate (TEP) on well-characterized nanopartides of hematite (alpha-Fe2O3), maghemite (gamma-Fe2O3), and goethite (alpha-FeOOH) has been studied by in situ diffuse reflectance infrared Fourier transform spectroscopy (DRIFTS), 2D correlation DRIFTS analysis, and X-ray photoelectron spectroscopy (XPS) on dry and water pre-covered surfaces. It is

Beating Signals in 2D Spectroscopy: Electronic or Nuclear Coherences? Application to a Quantum Dot Model System

In 2D electronic spectroscopy, oscillatory signals have recently received increased attention. The key issue is the origin of such beating-whether it is vibrational or electronic. In analogy to the distinction between rephasing and nonrephasing contributions to 2D spectra, we separate signal components with positive and negative coherence beating frequency via a third Fourier transformation and co

X-ray phase-contrast tomography with a compact laser-driven synchrotron source.

Between X-ray tubes and large-scale synchrotron sources, a large gap in performance exists with respect to the monochromaticity and brilliance of the X-ray beam. However, due to their size and cost, large-scale synchrotrons are not available for more routine applications in small and medium-sized academic or industrial laboratories. This gap could be closed by laser-driven compact synchrotron ligh

The Effect of Dietary Fiber from Wheat Processing Streams on the Formation of Carboxylic Acids and Microbiota in the Hindgut of Rats.

Colonic fermentation of dietary fiber produces carboxylic acids and may stimulate the growth of beneficial bacteria. This study investigated how byproducts of wheat processing (distillers' grains and two fractions from the wet fractionation to starch and gluten, one of which was treated with xylanase) affect the composition of the cecal microbiota and the formation of carboxylic acids in rats. Dif

Genetic Discrimination

In this article I discuss and analyse what is referred to as the standard account of discrimination as measured against a number of requirements any viable account of discrimination should satisfy. I also discuss how the standard account fails to explain how differential treatment based on genetic factors can be regarded as discriminatory.

Predicting Stock Price Volatility by Analyzing Semantic Content in Media.

Current models for predicting volatility do not incorporate information flow and are solely based on historical volatilities. We suggest a method to quantify the semantic content of words in news articles about a company and use this as a predictor of its stock volatility. The results show that future stock volatility is better predicted by our method than the conventional models. We also analyze

Upconversion dynamics in Er3+-doped YAG

Green, blue, violet and ultraviolet upconversion luminescence is reported at room temperature in a YAG: 10.5% Er3+ crystal pumped by one-colour (647 nm) and two-colour (647 + 618 nm) laser excitation. The upconversion mechanism was studied by means of time-resolved luminescence spectroscopy and the energy flow pathways are described. Based on the results it appears that energy transfer upconversio