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Purpose The purpose is to increase the IKEA knowledge regarding production of custom made worktops at two German suppliers, providing an action plan for the suppliers of how to increase product quality as well as calculating the potential cost savings and the product cost structure. Methodology The project is performed as two case studies, where both qualitative and quantitative data has been obta

A framework for optimizing the design of elastomer packaging machine tools, so­ called plunge tools, has been developed and has reached a proof­of­concept state in this thesis. The framework indicates the capability of decreasing prototype expenses and total development time of new plunge tools by roughly three times compared to the existing iterative design methodology. A finite element analysis

Stärka samhällen mot översvämning Översvämningar har inte bara en direkt, men också en indirekt effekt på viktiga funktioner i våra samhällen. Därför har Frida Kronquist undersökt hur Sveriges länsstyrelser hanterar översvämnings-risker med hjälp av geografiska informationssystem. Den naturkatastrof som förekommer oftast globalt sett är översvämningar. En översvämning kan orsaka oerhörd materieFlood is the most common natural disaster globally, affecting human health and assets. The work with the Swedish ordinance of flood risk is connected to the sustainment of vital societal functions. This thesis examines how direct and indirect effects of floods are considered in Swedish legislation and when the County Administrative Boards produce flood risk maps and management plans. Moreover, it

Reflektionsseismik har använts i forsknings- och prospekteringsändamål sedan första halvan av 1900-talet. De moderna undersökningar som utförs idag behandlar hela datainsamlingsförloppet digitalt och färdig-behandlad data tillgängliggörs sedan för geologisk tolkning i moderna datorprogram. Det finns dock en stor före-komst av äldre seismisk reflektionsdata som sparats ned på numera omoderna formatSeismic reflection data has been collected for more than half a century for both scientific and industrial purposes. Data sampled in modern surveys are collected, processed and stored digitally. There are, however, large quantities of vintage seismic reflection data that since its original use has been stored away and remains difficult to access in its current form. This data was acquired when it

With this research I have answered the twofold question of how Cuba played a part in the making of the Universal Declaration of Human Rights, and what differences and similarities that can be found between the Cuban draft of Human Rights versus the final product of the Universal Declaration of Human Rights. Since there is no previous research in this field I have chosen to look at some of the most

Oestrogen is not only a sex hormone but also an important regulator of the immune system. Expression of the heavy chain of IgM (mu) is essential for B-cell differentiation. However, a small number of IgA-positive B cells can be found in mice lacking the mu chain (mu MT-/-). The aim of this study was to investigate the effects of oestrogen on this alternative B-cell pathway in mu MT-/- mice. Our re

Context:A common genetic variant (rs10423928, A-allele) in the glucose-dependent insulinotropic polypeptide receptor gene (GIPR) is associated with decreased insulin secretion. Glucose-dependent insulinotropic polypeptide is secreted after food consumption and gipr knockout mice fed a high-fat diet are protected against obesity and disturbances in glucose homeostasis. Objective:Our objective was

Popular Abstract in Swedish Det finns ett starkt samband mellan kronisk inflammation och cancer. Ett av de mer etablerade sambanden är den mellan kronisk inflammation i tarmen och den i Sverige tredje vanligaste cancersjukdomen, nämligen tjocktarmscancer. Risken för tjocktarmscancer korrelerar med inflammationsutbredning, varaktighet och svårighetsgrad. Den inflammatoriska processen regleras av reCysteinyl leukotrienes (LTC4, LTD4 and LTE4) are potent pro-inflammatory lipids derived from arachidonic acid and mediate their effect through CysLT1R and CysLT2R. There is a strong correlation between long-standing inflammatory bowel disease where these pro-inflammatory mediators are abundant and colorectal cancer. We have shown that LTD4 via its receptor CysLT1 induces expression of proteins ass

The reliability of radiation dose estimates in internal radionuclide therapy is directly related to the accuracy of activity estimates obtained at each imaging time point. The recently published MIRD pamphlet no. 23 provided a general overview of quantitative SPECT imaging for dosimetry. The present document is the first in a series of isotope-specific guidelines that will follow MIRD 23 and focus

We studied if bladder cancers respond to HAMLET (human alpha-lactalburnin made lethal to tumor cells) to establish if intravesical HAMLET application might be used to selectively remove cancer cells in vivo. Patients with nonmuscle invasive transitional cell carcinomas were included. Nine patients received 5 daily intravesical instillations of HAMLET (25 mg/ml) during the week before scheduled sur

Objective: GH causes insulin resistance, impairs glycemic control and increases the risk of vascular diabetic complications. Sulphonylureas stimulate GH secretion and this study was undertaken to investigate the possible stimulatory effect of repaglinide and nateglinide, two novel oral glucose regulators, on critical steps of the stimulus-secretion coupling in single rat somatotrophs. Methods: Pat

By emphasising the involvement of elderly people in a project applying a mixed-method approach, the overriding objective of this study was to identify and prioritise concrete measures aimed at increasing accessibility and safety in the outdoor pedestrian environment within a residential area of a Swedish town. Measures generally given priority were: the separation of pedestrians/cyclists, lower sp

Mercury and selenium in whole blood and serum of 245 17-year old Swedish adolescents were analysed. The relationships between these elements' concentrations and the consumption of fish as well as the number of dental amalgam fillings were studied. The geometric means (GM) of the mercury concentrations were 1.1 mug/L in blood and 0.43 mug/L in serum. The mean selenium concentration in blood was 110

The morphology of gas-rich disc galaxies at redshift ∼ 1–3 is dominated by a few massive clumps. The process of formation or assembly of these clumps and their relation to molecular clouds in contemporary spiral galaxies are still unknown. Using simulations of isolated disc galaxies, we study how the structure of the interstellar medium and the stability regime of the discs change when varying the

Upregulation of carbonic anhydrase IX (CA IX) is associated with several aggressive forms of cancer and promotes metastasis. CA IX is normally constitutively expressed at low levels in selective tissues associated with the gastrointestinal tract, but is significantly upregulated upon hypoxia in cancer. CA IX is a multi-domain protein, consisting of a cytoplasmic region, a single-spanning transmemb

Changes in dilution of wastewater to a treatment plant due to infiltration or surface runoff can have a great impact on treatment process performance. This paper presents a model-based approach in which realistic influent scenarios are generated and used as inputs to a dynamic plant-wide process model of the wastewater treatment plant. The simulated operation is subsequently evaluated using life-c

OBJECTIVE: To evaluate the feasibility of a randomized controlled pilot study with lifestyle-promoting text messages as a treatment for hypertension in primary care.DESIGN: Randomized controlled pilot trial.SETTING: Three primary health care centers in southern Sweden.SUBJECTS: Sixty patients aged 40-80 years with hypertension were included.MAIN OUTCOME MEASURES: Feasibility of the pilot study, i.

Increased incidence of narcolepsy type 1 (NT1) was observed following Pandemrix®‐vaccination, initiated as a preventive measure against the 2009 Influenza pandemic. Here, single cell analysis was conducted to suggest a lower number of CD8+CD27+ T cells among these patients. These findings provide understanding into the autoimmune pathogenesis of NT1.