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Polyethylene Wear With Ceramic and Metal Femoral Heads at 5 Years : A Randomized Controlled Trial With Radiostereometric Analysis

Background: A common bearing combination in total hip arthroplasty today is a metal femoral head articulating with polyethylene in the cup. Ceramic heads are thought to be more resistant to third-body damage, and have better wettability and decreased surface roughness, which taken together have been suggested to result in less polyethylene wear. The purpose of this study is to compare the initial

Living Off-Grid: A Study of Sustainable Transformations Across Practical, Political, and Personal Spheres

Off-grid living offers an alternative path to sustainability, but its complex dynamics require deeper exploration. Utilizing the Three Spheres of Transformation theoretical framework, the study uses interviews to explore the motivations for, barriers to and necessary changes for off-grid living from the perspective of individuals. Findings from interviews with people living and aspiring to live of

“The forest is gone bit by bit" - Deforestation and its impacts on indigenous communities in Prey Lang, Cambodia

Globally, deforestation is occurring at staggering rates and causing tremendous impacts on the planet. Indigenous people, in particular, have long depended on the forest, and their beliefs and ways of life are highly affected by the changes occurring around them. To explore these impacts, Kuy indigenous people living in Pneak Roluk, inside the Prey Lang forest in Cambodia, have been selected as a

The Circular Economy – A new sustainability paradigm?

While the terms Circular Economy and sustainability are increasingly gaining traction with academia, industry, and policymakers, the similarities and differences between both concepts remain ambiguous. The relationship between the concepts is not made explicit in literature, which is blurring their conceptual contours and constrains the efficacy of using the approaches in research and practice. Th

An instrument variable based algorithm for estimating cross-correlated hydrological remote sensing errors

Optimally using multi-source remote-sensing (RS) and/or reanalyzed hydrological products requires knowledge of each product's accuracy and inter-product error cross-correlations. Quadruple collocation (QC) analysis can potentially solve for this error information without the reliance of high-quality ground references. However, QC requires at least three independent products for a variable of inter

A cell topography-based mechanism for ligand discrimination by the T cell receptor

The T cell receptor (TCR) initiates the elimination of pathogens and tumors by T cells. To avoid damage to the host, the receptor must be capable of discriminating between wild-type and mutated self and nonself peptide ligands presented by host cells. Exactly how the TCR does this is unknown. In resting T cells, the TCR is largely unphosphorylated due to the dominance of phosphatases over the kina

Spatiotemporal analysis of nonlinear trends in precipitation over Germany during 1951–2013 from multiple observation-based gridded products

Spatial and temporal patterns of trends in annual and seasonal precipitation over Germany during 1951–2013 were analysed using the ensemble empirical mode decomposition (EEMD) method. Three widely used and recognized high-resolution observation-based gridded precipitation products, the Climatic Research Unit (CRU) time-series data, Global Precipitation Climatology Centre (GPCC) Full Data Reanalysi

Signaling via β2 integrins triggers neutrophil-dependent alteration in endothelial barrier function

Activation of polymorphonuclear leukocytes (PMNs) and adhesion to the endothelial lining is a major cause of edema formation. Although known to be dependent on the function of β2 integrins (CD11/CD18), the precise mechanisms by which adherent PMNs may impair endothelial barrier capacity remain unclear. Here, the role of transmembrane signaling by β2 integrins in PMN-induced alterations in tight ju

High diagnostic accuracy for idiopathic Addison’s disease with a sensitive radiobinding assay for autoantibodies against recombinant human 21-hydroxylase

Autoantibodies against 21-hydroxylase (P450c21) are common in idiopathic autoimmune Addison’s disease. In the present work, we have developed a sensitive radiobinding assay using in vitro translated recombinant human 35S-P450c21. Levels of P450c21 antibodies (P450c21-Ab) were expressed as a relative index (P450c21 index) using a P450c21-Ab positive Addisonian serum and two antibody-negative health

Airborne and Dermal Exposure to Polycyclic Aromatic Hydrocarbons, Volatile Organic Compounds, and Particles among Firefighters and Police Investigators

AIMS: The main aim of this study was to assess dermal exposure to polycyclic aromatic hydrocarbons (PAHs) and airway exposure to PAHs, volatile organic compounds (VOCs; benzene and 1,3-butadiene), and particles among firefighters (FFs) and police forensic investigators (PFIs) in Sweden. METHODS: Active (pump with a filter and sorbent tube) and passive (polyurethane foam -cyl and perkin elmer carbo

User involvement in housing recovery after typhoon Haiyan from a capability perspective

Typhoon Haiyan hit the Philippines on 8th November 2013 destroying more than 1 million houses and affecting mostly the poor. This paper discusses user involvement in housing recovery from a capability perspective. The paper also analyses possibilities for extension of the housing solutions. Based on the Sphere handbook and the theoretical framework, a Model for user involvement in evolutionary hou

Traffic conflicts analyses for 2+1 road sections

The additional passing lanes and 2+1 roads improve significant road safety. Studies indicate sections with additional passing lanes (relief or alternately), which may cause reduction in the number of accidents by 50%. However, how geometric design affects the safety performance of such sections is not in depth investigated. Previous studies are carried out with two approaches, i.e. the most often,

Sequentially loop-generated quark and lepton mass hierarchies in an extended Inert Higgs Doublet model

Extended scalar and fermion sectors offer new opportunities for generating the observed strong hierarchies in the fermion mass and mixing patterns of the Standard Model (SM). In this work, we elaborate on the prospects of a particular extension of the Inert Higgs doublet model where the SM hierarchies are generated sequentially by radiative virtual corrections in a fully renormalisable way, i.e. w

What makes an ally? Sweden and Finland as NATO’s closest partners

From 2013 onward, Sweden and Finland gradually distinguish themselves from all other NATO partners in order to meet the growing challenge how to defend the Baltics. In the analysis, the concept of ‘informal ally’, in contrast to ‘formal ally’, is introduced. A synthesized analytical framework is used to evaluate the process of ever closer partner cooperation and its shifting focus from cooperative

Retrieving photochemically active structures by time-resolved EXAFS spectroscopy

Describing the nature and structure of molecular excited states is important in order to understand their chemical reactivity and role as intermediates in photochemical reactions. The recent implementation of X-ray absorption spectroscopy in the ultrafast time domain allows studying the electronic and structural dynamics of photochemically active molecules in solutions. In this work we present the

Glaucoma Hemifield Test. Automated visual field evaluation

We have developed an algorithm, the Glaucoma Hemifield Test (GHT), for automated evaluation of single static threshold visual field test results in glaucoma. The GHT uses empirically determined limits of normality for up-down differences in the Statpac probability maps of the Humphrey Field Analyzer to detect localized visual field loss. It is also constructed to detect field loss that is symmetri