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Skeletal muscle is a dynamic tissue with a remarkable ability to continuously respond to environmental stimuli. Among its adaptive responses is the widely investigated ability of skeletal muscle to regenerate after loading or injury or both. Although significant basic science efforts have been dedicated to better understand the underlying mechanism controlling skeletal muscle regeneration, there h

Popular Abstract in Swedish Drygt en tiondel av Sveriges befolkning lider av hjärt-kärlsjukdom som också är den vanligaste dödsorsaken. Många av de akuta sjukdomstillstånden orsakas av att en bit inflammerad blodkärlsvävnad bryts loss från sitt fäste i något av de stora blodkärlen, färdas med blodet och täpper till blodflödet i mindre blodkärl. Detta leder till syrebrist och celldöd nedströms om dAbstract Atherosclerosis is a multifactorial disease, but an unbalanced immune system plays a critical role in the disease development. A common theory states that a continuous stress to the vascular vessel wall initiates a repair process that however is insufficient to completely heal the tissue. This imbalance is associated with accumulation of cholesterol, which is an essential component of ce

The objective of this study was to examine to what extent ergonomics simulations of manual assembly tasks correctly predict the real outcomes in the plants and if recommended measures originating from ergonomics simulations are taken into consideration. 155 ergonomics simulation cases were used in the study and all cases were performed by nine simulation engineers at Volvo Car Corporation in Gothe

Popular Abstract in Swedish Ett felaktigt protein som klumpar ihop sig i hjärnans blodkärl är orsaken till hjärnblödning och för tidig död hos unga islänningar. Sjukdomen är ärftlig och uppkommer på grund av en enda felaktig byggsten, orsakad av en mutation, i proteinet cystatin C. Det muterade proteinet bildar mikroskopiska proteinkedjor, fibriller, som klumpar ihop sig i bland annat hjärnans bloThe pathophysiological process in Alzheimer’s disease and other amyloid disorders usually involves the transformation of a soluble monomeric protein via potentially toxic oligomers into amyloid fibrils. The structure and properties of the intermediary oligomers have been difficult to study due to their instability and dynamic equilibrium with smaller and larger species. This has hampered the devel

Aims and objectives. This study aimed to describe and identify risk factors associated with hospital-acquired pressure ulcers among adults in an acute care hospital compared with patients with pre-existing pressure ulcers present on admission. A further aim was to identify the preventive measures performed with both groups respectively. Background. Pressure ulcers occur most often in older and imm

Kulturskolan når över 400 000 barn i Sverige årligen. Institutionen har trots det inget definierat uppdrag på nationell nivå men frågan om vad institutionens uppdrag kan tänkas vara aktualiseras ofta i olika sammanhang. Ett återkommande tema är om Kulturskolan ska förvalta ett kulturarv eller följa marknadsestetiken. Syftet med studien är att ur Kulturskolechefernas perspektiv undersöka KulturskolOver 400,000 children attend Sweden’s Kulturskolor, or municipal schools of music and arts, every year, and yet despite this the schools have no national mission or goals, even though the question of what that mission might be is frequently raised. One common line is that the schools should exist to curate and disseminate cultural heritage; another, that they should bow to market aesthetics. The a

Förorenar Arktiska samhällen sig själva och påverkas marina organismer i samband med detta? Ja, bara i Adventfjorden och Grønfjorden på Svalbard finns förorening från lokala källor för 14 av 57 analyserade flamskydds- och ytbehandlingsämnen i sediment. Inte så mycket tänker kanske du? Men den största anledningen till förekomsten av dessa ämnen är utsläpp av orenat avloppsvatten och läckage från sMost of the ecotoxicological research conducted in the Arctic until today has focused on long range transport of pollutants, while fewer studies on local pollution have been published. The aim of this study was hence to investigate if local pollution of organophosphorus flame retardants (OPFRs), polybrominated diphenyl ethers (PBDEs) and perfluorinated alkylated substances (PFAS) occurs outside tw

This thesis investigates Twitter posting in Greek during the period of the Greek referendum in 2015 and in particular between June 27, when the referendum was announced, and July 6, one day after the referendum was completed, and how the Greek people use various external sources to express themselves (i.e. political thoughts, actions, inquires). The main research question is “What is the role of i

Uppsatsen behandlar kravet på tillräckliga kvalifikationer i 7 §, 22 §, 25 § och 25 a § LAS. Ur ett arbetsrättsligt perspektiv studeras vilka kvalifikationer arbetstagaren måste uppfylla för att åtnjuta rätten till omplacering respektive företräde. Rättspraxis spelar en stor roll i begreppstolkningen då lag och lagmotiv inte bidrar med någon definition av begreppet. I arbetet studeras även om, ochThe essay concerns the requirement of sufficient qualifications in 7 §, 22 §, 25 § och 25 a § LAS. From a labour law perspective the qualifications which the employee has to fulfil to enjoy the right to redeployment and precedence are studied. Case-law is an important source in the interpretation of the concept of sufficient qualifications since its' meaning is not defined by law or preparator

Every year two billion tons of MSW are produced globally. Due to the impact of solid waste and population growth, it is necessary to develop an integrated solid waste management plan. Such a plan, holistic in scope, would aim to minimize the negative impact of this material in the environment while being economically viable. The designation and terming of any one mode of waste treatment as superio

Neutron reflectometry is a powerful tool used for studies of surfaces and interfaces. The absorption in the typical studied materials is neglected and this technique is limited only to the reflectivity measurement. For strongly absorbing nuclei, the absorption can be directly measured by using the neutron-induced fluorescence technique which exploits the prompt particle emission of absorbing isoto

The effects of self-assembly on the hydrolysis kinetics of surfactants that contain ester bonds are discussed. A number of examples on how reaction rates and apparent reaction orders can be modulated by changes in the conditions, including an instance of apparent zero-order kinetics, are presented. Furthermore, it is shown that the examples on reaction kinetics display parallels and connections to

Popular Abstract in Swedish Endokrina och metabola sjukdomstillstånd har många gemensamma komponenter. Att förstå de signalvägar som ligger till grund för dessa sjukdomar hjälper oss att utveckla bättre behandlingsmetoder. Det övergripande syftet med min forskning är att undersöka den roll s.k. G-protein kopplade receptorer spelar i endokrina metaboliska sjukdomar, mer specifikt de signalvägar somThe aims of this dissertation were to investigate the effects of extracellular purines on insulin secretion, and apoptosis in mouse pancreatic islets and β-cells; to examine if high glucose and free fatty acids induces β-cell apoptosis via autocrine effects of ADP acting on the P2Y13 receptor; and to investigate the modulation of extracellular purines in vascular smooth muscle cells (VSMCs) throug

When selecting the least biased exposure surrogate, for example, the concentration of a biomarker in a urine sample, information on variability must be taken into consideration. We used mixed-effects models to estimate the variability and determinants of urinary cadmium (U-Cd) excretion using spot urine samples collected at six fixed times during 2 days about 1 week apart, from 24 healthy non-smok

Popular Abstract in Swedish Bakgrund och syfte med avhandlingen Glutenintolerans, celiaki är en av de vanligaste kroniska sjukdomarna bland barn och innebär att man inte tåler gluten, som är ett protein och finns i vete, råg och korn. Tunntarmen har en veckad slemhinna med fingerlika utskott , tarmludd och hela tarmen har en yta på 250 kvadratmeter, vilket är lika stort som en tennisplan. Den stBackground: The prevalence of celiac disease (CD) is estimated to be around 1%, but most CD cases are undiagnosed. Sweden experienced an epidemic of clinically detected celiac disease in children younger than 2 years of age, partly due to changes in infant feeding practices, were the amount of gluten and age at introduction was changed. However, it was not clear if the increase in clinically detec

Breast cancer treatment is based on tumor and patient related factors such as tumor stage, grade, hormonal status, HER2 status, patient age, and family history to name a few. It is today widely acknowledged that hypoxia and hypoxia-inducible factors (HIF:s) contribute to tumor progression. We therefore set out to explore the impact of hypoxia on mammary epithelial differentiation and what conseque

Non-invasive positive pressure ventilation (NPPV) improves health-related quality of life (HRQL) in patients with chronic alveolar hypoventilation (CAH). We studied the prognostic impact of HRQL on survival in relation to clinical factors. Forty-four patients with CAH due to post-polio (12), scoliosis (11), post-tb (17) or other diagnoses (4) who received nocturnal NPPV were prospectively studied