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A surge in societal and scientific discussion surrounds psychedelic research. One surprising fact keeps standing out: Many users report the psychedelic experience as a positive and lasting impact on their quality of life. The present study aimed to explore the quality and consequences of the most impacting psychedelic experience, with the user's Big Five personality in focus. This experienced samp

This paper combines density-based topology optimization (TO) with a “contact aware” shape optimization (SO) which combines the design freedom of TO with the precise boundary representation of SO. Using gradient based optimization, the objective is to design structures in frictionless contact, including the shape of the contacting surfaces. SO is performed on each contacting structure which defines

An applied quantitative complement for fundamentally driven hedge funds incorporating non-normal modeling and asset allocation optimization

The purpose of this paper is to make a personal reflection of the last year when I have been studying the Master’s Programme in Entrepreneurship at Lund University and the experiences I have had during this time. This paper mainly explores the importance of legitimacy and what you need to do to adapt and maybe change to fit in on a market but also the importance of trust, both within your own orga

Background: Upright birth positions may reduce the risk for instrumental delivery. The aim of this study was to test, by means of a randomised controlled trial, the hypothesis that the use of a birthing seat during the second stage of labour decreases the number of instrumental deliveries and thus counterbalance any adverse perineal outcome or severe blood loss.M

ABSTRACT: Baz-Valle, E, Fontes-Villalba, M, and Santos-Concejero, J. Total number of sets as a training volume quantification method for muscle hypertrophy: A systematic review. J Strength Cond Res 35(3): 870-878, 2021-This review aimed to determine whether assessing the total number of sets is a valid method to quantify training volume in the context of hypertrophy training. A literature search o

Basis pursuit (BP), basis pursuit deNoising (BPDN), and least absolute shrinkage and selection operator (LASSO) are popular methods for identifying important predictors in the high-dimensional linear regression model (Formula presented.). By definition, when (Formula presented.), BP uniquely recovers (Formula presented.) when (Formula presented.) and (Formula presented.) implies (Formula presented

Activation of the Met receptor tyrosine kinase, either by its ligand, hepatocyte growth factor (HGF), or via ligand-independent mechanisms, such as MET amplification or receptor overexpression, has been implicated in driving tumor proliferation, metastasis, and resistance to therapy. Clinical development of Met-targeted antibodies has been challenging, however, as bivalent antibodies exhibit agoni

We construct a 2-generated pro-2 group with full normal Hausdorff spectrum [0, 1] [0,1], with respect to each of the four standard filtration series: the 2-power series, the lower 2-series, the Frattini series, and the dimension subgroup series. This answers a question of Klopsch and the second author, for the even prime case; the odd prime case was settled by the first author and Klopsch. Also, o

Kort efter att hon bevittnat den franska revolutionens fasor i Paris reste den engelska filosofen och feministen Mary Wollstonecraft till ett sömnigt Skandinavien. Kontrasterna kunde inte ha varit större. Ändå var det just i Sverige som hennes sista, stora politiska fråga väcktes: Hur förändrar man ett samhälle? Lena Halldenius följer Wollstonecraft på hennes sista filosofiska resa.Bildningsboxen

Climbing fibers, which originate in the inferior olive and project to Purkinje cells and Golgi cells in the cerebellar cortex, were activated at low (0.4-Hz) and high (4-Hz) frequencies by peri-orbital stimulation in decerebrate ferrets. Climbing fiber responses were recorded as field potentials from the c3 zone of the cerebellar surface. When periorbital stimulation was applied at high frequency,

The flexibility of β hairpin structure known as the flap plays a key role in catalytic activity and substrate intake in pepsin-like aspartic proteases. Most of these enzymes share structural and sequential similarity. In this study, we have used apo Plm-II and BACE-1 as model systems. In the apo form of the proteases, a conserved tyrosine residue in the flap region remains in a dynamic equilibrium

How do we explain change in political transnationalism over time? In what way does this change affect diasporic identities? And how does this change alter the relationship and power of diasporic actors towards their homeland states? This paper addresses these questions in relation to Iraqi Shi’a political transnationalism between London and Iraq pre and post-2003. I argue that the confluence of po