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Behandlar premisserna för Nationalmuseums framtida verksamhet när det gäller renovering och nybyggnation på Blasieholmen.

Tobacco smoking is a major health and economic concern and is also known to have a significant negative effect on surgical outcomes. The benefits of a smoking cessation intervention prior to elective orthopaedic surgery have been evaluated previously. Our aim was to assess whether a smoking cessation program, initiated during the acute hospitalization period and carried out for six weeks, could re

This article examines the interpretation of biosignatures, the signs of life that could bedetected in outer space. In astrobiology biosignatures could be of various kinds, fossils, molecules, traces, artefacts, structures, electromagnetic waves, etc. The purpose of this article is to bring some semiotic order in this seemingly chaotic variation of signs. It turns out that the semiotic function of

ABSTRACT In a patient with advanced Hodgkin's disease (HD) associated with generalized pruritus, an unexpected relief of itching was found to be an early sign of spinal cord compression. Following irradiation of an extradural mass at the Th II level, itching recurred. Although the mechanisms bringing about itching in HD are unknown, the relief and recurrence of the symptom in our patient are in li

Cholecystectomy has been connected with an increase in colorectal, breast and reproductive system cancers. On 472 patients, 398 women and 74 men, cholecystectomized during the years 1951 to 1955, cancer incidence was investigated. Our results show an elevated risk of breast cancer in the female group (P = 0.016), but no significant increased risk in colorectal or gynaecologic cancer. The risk for

Purpose: This article hypothesizes that designing cancer therapies based on the organ specific toxicity of the normal tissue of the organ from which the tumors originated could be worthwhile. A prerequisite for successful therapy is that the individual can recover from damage done to the organ or cells.Results: Therapeutic examples are given for lymphoma, kidney cancer, melanoma and leukemia.Concl

Calculating binding free energies with quan-tum-mechanical (QM) methods is notoriously time-consum-ing. In this work, we studied whether such calculations can beaccelerated by using nonequilibrium (NE) moleculardynamics simulations employing Jarzynski’s equality. Westudied the binding of nine cyclic carboxylate ligands to theocta-acid deep-cavity host from the SAMPL4 challenge withthe reference po

We have devised a new efficient approach tocompute combined quantum mechanical (QM) and molecularmechanical (MM, i.e. QM/MM) ligand-binding relative freeenergies. Our method employs the reference-potentialapproach with free-energy perturbation both at the MMlevel (between the two ligands) and from MM to QM/MM(for each ligand). To ensure that converged results areobtained for the MM → QM/MM perturb

This paper studies political career incentives in a nondemocratic historical setting to assess early political institutions. We construct a novel panel database of governors of Imperial Russia in 91 provinces between 1895 and 1914. Measuring an imperial governor’s performance by his ability of peacekeeping, we test whether the central authorities in the Russian Empire resorted to career incentives

This article attempts to contribute to the development of a positive theory on the management of intangibles by building a model that describes the process followed by business firms willing to implement a system for the management of intangibles. The study reveals that companies usually take three steps: the identification of critical intangibles related to value creation, the measurement of thos

Machine learning is a powerful technique, becoming increasingly popular in astrophysics. In this paper, we apply machine learning to more than a thousand globular cluster (GC) models simulated with the mocca-Survey Database I project in order to correlate present-day observable properties with the presence of a subsystem of stellar mass black holes (BHs). The machine learning model is then applied

Relative free energies for the binding of nine cyclic carboxylate ligands to the octa-acid deep-cavity host were calculated at the combined density-functional theory and molecular mechanics (DFT/MM) level of theory. The DFT calculations employed the BLYP functional and the 6-31G∗ basis set for the ligand. We employed free-energy perturbatio