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We study the isotonic regression estimator over a general countable pre-ordered set. We obtain the limiting distribution of the estimator and study its properties. It is proved that, under some general assumptions, the limiting distribution of the isotonized estimator is given by the concatenation of the separate isotonic regressions of the certain subvectors of an unrestrecred estimator’s asympto
Circular business models aim to preserve the value of material resources in society by slowing and closing resource flows. Various models have been identified, including the Extending Product Value business model, which plays a role in extending product lifetimes by reversing product obsolescence. However, the characteristics of these business models and their associated environmental consequences
Experiments on the excitation of propagating surface plasmons (SPs) by an ultrashort, high intensity laser interaction with grating targets are reviewed. At intensities exceeding 10 19 W cm
The dissolution of Yugoslavia in the nineties brought a series of armed conflicts, civil wars and outright war to the Balkan Peninsula. The Serbian Orthodox Church (SOC) was entangled in these conflicts. The SOC’s involvement in these wars has sparked an academic discussion about the role of religion, especially that of the SOC, in these conflicts. This discussion has so far mainly been social sci
Motivated by the large number of solutions obtained when applying bifurcation algorithms to the Ornstein-Zernike (OZ) equation with the hypernetted chain (HNC) closure from liquid state theory, we provide existence and bifurcation results for a computationally-motivated version of the problem. We first establish the natural result that if the potential satisfies a short-range condition then a low-
This conclusion presents some closing thoughts on the concepts covered in the preceding chapters of this book. The book empirically and comparatively, indicates the extent to which there is continuity or change in the foreign policy composition of key European Union (EU) Member States, as found across the 'strong-weak competence spectrum', and on this basis explore the extent to which the resultin
The Nehruvian policies propagated upon India’s independence envisaged no place for religion in political mobilization. Still, religion has continued to affect and influence Indian politics, even as India has become progressively affected by processes of liberalization and globalization. The particular politics of Indian secularism was based on keeping a distance from matters of faith and custom. H
The articles in this special issue consider the institutional foundations of the Union’s criminal policy – a highly critical question for the future development of the Area of Freedom, Security and Justice. The ratification of the Lisbon Treaty and the subsequent legal and political developments have entailed an unprecedented reinforcement of the powers of the EU’s criminal justice agencies Europo
To survive organisms must defend themselves against pathogens. Classical Major Histocompatibility Complex (MHC) genes play a key role in pathogen defense by encoding molecules involved in pathogen recognition. MHC gene diversity influences the variety of pathogens individuals can recognize and respond to and has consequently been a popular genetic marker for disease resistance in ecology and evolu
As the literature on entrepreneurship education grows, the issue of equality in entrepreneurship education has been raised; i.e., whether students are educated to become entrepreneurs equally. This article provides a critical and thought-provoking analysis of a portfolio of practices that, on the surface, appear to be successful in training entrepreneurs. To this purpose, we initiate a debate on w
Myrosinase from Sinapis alba hydrolyzes glycosidic bonds of β-d-S-glucosides. The enzyme shows an enhanced activity in the presence of l-ascorbic acid. In this work, we employed combined quantum mechanical and molecular mechanical (QM/MM) calculations and molecular dynamics simulations to study the catalytic reaction of wild-type myrosinase and its E464A, Q187A, and Q187E mutants. Test calculation
Technology and innovation are important in addressing complex problems in the agricultural sector in many developing communities. However, ways and mechanisms to integrate them in the agricultural sector are still a challenge due to the lack of clear pathways and trajectories. Value chains are seen as a strong policy instrument to increase profitability in the agricultural sector; there is also de
