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Uncoupling protein 2 (UCP2) is upregulated in the brain after sublethal ischemia, and overexpression of UCP2 is neuroprotective in several models of neurodegenerative disease. We investigated if increased levels of UCP2 diminished neuronal damage after global brain ischemia by subjecting mice overexpressing UCP2 (UCP2/3tg) and wild-type littermates (wt) to a 12-min global ischemia. The histopathol
A two-echelon distribution inventory system with a central warehouse and a number of retailers is considered. The retailers face stochastic demand. The system is controlled by continuous review installation stock (R,Q) policies with given batch quantities. There are linear holding costs at all locations and linear backorder costs at the retailers. We present a simple technique for approximate opti
In 231 diffuse large B-cell lymphomas, the expression of cyclin D1 and CD5 was evaluated. All cases were CD5-. Ten (4.3%) were positive for cyclin D1 and were subjected to fluorescence in situ hybridization at the CCND1 locus. One case showed the t(11;14). In another case, the telomeric probe signal for cyclin D1 was lost in most tumor cells, and in a small proportion of the cells, there were fluo
This randomized trial evaluates whether automated telephony could be used to perform daily assessments in paroled offenders (N = 108) during their first 30 days after leaving prison. All subjects were called daily and answered assessment questions. Based on the content of their daily assessments, subjects in the intervention group received immediate feedback and a recommendation by automated telep
Permutational Grammar, PG, is a grammar inspired by the Free Word Order grammar, FOG, presented in Vladimir Pericliev & Alexander Grigorov 1992. Some languages, notably Latin, are said to have free word order, see e.g. Siewierska 1988. The name Permutational Grammar is derived from the use of permutations in order to generate order variation. The general problem to be solved by FOG and PG is t
Most adult patients with congenital heart disease (CHD) have reduced aerobic exercise capacity. Their habitual physical activity (PA) level is, however, less well studied. In this study, habitual PA level in a cohort of adults with CHD compared with healthy age- and sex-matched controls was investigated.
Studies on the molecular mechanisms behind soft tissue sarcoma development have disclosed that these malignancies are as genetically heterogeneous as they are clinically and morphologically diverse. Much of the genetic information on soft tissue sarcomas is still limited to the genomic level, as detected by chromosome banding analysis or comparative genomic hybridization. Based on the results of s
The negation width of a Boolean AND, OR, NOT circuit computing a monotone Boolean function f is the minimum number w such that the unique formal DNF produced (purely syntactically) by the circuit contains each prime implicant of f extended by at most w solely negated variables. The negation width of monotone circuits is zero. We first show that already a moderate allowed negation width can substan
Background: Pancreatic ductal adenocarcinoma is a highly fatal malignancy. The aim was to identify preoperative factors for early mortality in up-front resectable patients following pancreatoduodenectomy (PD) and develop an early mortality risk score. Methods: Patients registered in the Swedish National Registry for Pancreatic and Periampullary Cancer were included. Relevant preoperative factors (
The educational opportunities of refugee learners are shaped by forces of globalization, restrictive mobility regimes and geopolitical agendas, that place them in a position of structural disadvantage. The majority of the world's refugee learners have fled due to armed conflict and reside in neighboring countries in the global South. In many cases forced displacement is protracted, with limited gl
Women tend to have lower interest in engineering as compared to men, which previous research has shown is partly explained by gender differences in self-efficacy, social belongingness and communal career goals. Therefore, to attract more women to engineering, effective interventions are needed that target these factors. In this study, we evaluated an industry-designed intervention for high school
Department of Science and Technology, India recently released the S&T indicators for the year 2019-20 which once again reveals the stagnation of India's gross expenditure in R&D at 0.7 percent of the GDP. The R&D trends such as contribution by private sector and higher education sectors in R&D shows a continuous rise in absolute figures although their share in total R&D remains
Abstract på spanskaUna de las fuentes más sólidas de nuevo conocimiento sobre las categorías tipológicas proviene de nuestro creciente entendimiento de las lenguas indígenas de América del Sur, una región que hasta hace poco ha estado significativamente subrepresentada en los estudios tipológicos. Este artículo ofrece un ejemplo a través de la investigación del número en nadëb, un miembro de la peOne of the most robust sources of fresh insights into typological categories comes from our growing knowledge of the indigenous languages of South America, a region that until recently has been significantly under-represented in typological studies. This paper offers a case in point through the investigation of number in Nadëb, a member of the small Naduhup family of the northwest Amazon, which re
From a radiation protection point of view, nuclear medicine is a complex medical specialty that includes both radionuclide and radiopharmaceutical production and patient diagnostics and therapy. The practical work with radiation sources includes a variety of procedures, activity levels, dose rates, and risks of contamination. The radiation dose to the worker is largely determined by the knowledge
