Effects of pentobarbital on GABA-activated currents in acutely-isolated rat dentate gyrus granule neurons
Granule neurons from the rat dentate gyrus were acutely isolated and whole-cell currents recorded. Maximal enhancement of 7 muM gamma-aminobutyric acid (GABA; EC30) evoked currents was obtained with 100 muM pentobarbital where the peak-current was 2.1 +/- 0.2 of control. One hundred muM pentobarbital alone evoked no current response whereas I mM pentobarbital elicited a current response that was 0
