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Over the last two decades, the social identity of the jihadist has become a central part of street culture. Depictions of jihadists can be found in popular music, movies and media reports. Propaganda celebrating or condemning jihadism circulates online, and a significant number of individuals with a background in street crime have flirted with or converted to jihadism. Drawing on ethnographic fiel

Article 12 of the UN Convention on the Rights of Persons with Disabilities requires states parties to take appropriate measures to ensure that persons with disabilities have access to the support they may need in exercising their legal capacity. However, this obligation remains ambiguous. What exactly is decision-making support meant to accomplish? Until this fundamental issue has been clarified,

Background: Viral infections, including COVID-19, are associated with an increased risk for type 1 diabetes (T1D), but potential underlying mechanisms remain unexplored. We evaluated whether COVID-19 or influenza A infection is characterized by differential DNA methylation at immune and T1D susceptibility genes in young children at risk for T1D. Methods: Epigenome-wide association analysis using t

Field relationships and petrology of a mid Proterozoic (1624 ±6 Ma) hornblendite from southwestern Sweden demonstrate that it originated as a mafic-ultramafic hydrous melt. Lobes and veins of hornblendite penetrate the surrounding gneiss and small gneiss xenoliths lie in the main body of the hornblendite, evidence that it intruded with relatively low viscosity. The hornblendite has a composition c

The retinoblastoma gene (RB1), which is located on chromosome 13q14.2, is mutated in retinoblastoma (RB), the most common malignant intraocular tumor in children. About 8000 new cases of retinoblastoma are diagnosed globally each year, accounting for approximately 1 in 17,000 live births. RB is prototypically considered hereditary by nature as thirty to forty percent of cases have autosomal domina

Micropollutants in wastewater can persist through conventional treatment, threatening ecosystems and human health through toxicity, bioaccumulation, and disruption of biological processes. Limited monitoring, due to cost and methodological challenges, allows these compounds to go undetected, potentially leading to long-term, irreversible impacts. To address this, modern wastewater treatment plants

UNLABELLED: The primary objective of this study was to investigate whether ligand-receptor interactions (LRIs) between IGHG and FCGR gene products are associated with progression to type 1 diabetes (T1D). Using two completed clinical trials (DPT-1 and TN07), we applied next-generation targeted sequencing to genotype IGHG and FCGR genes in a cohort of 1,214 individuals and assessed LRI associations

The dependence of f0(980) production on the final-state charged-particle multiplicity in p–Pb collisions at sNN=5.02 TeV is reported. The production of f0(980) is measured with the ALICE detector via the f0(980)→π+π− decay channel in a midrapidity region of −0.5

Objective The investigation of complement factors in lupus nephritis (LN) in relation to treatment response and the impact of underlying genetics of C4. Methods Seventy-seven patients with active LN confirmed by a kidney biopsy and in whom second biopsies had been performed after immunosuppressive treatment were included. Complement factors C3, C4, C4d and C4d/C4 ratio were evaluated at the biopsy

Incidence of early-onset (< 40 years) type 2 diabetes (T2D) is increasing. While multiple risk factors have been identified, particularly obesity and low socioeconomic status, early-life factors are hypothesised to play a role via fetal programming. We investigated sociodemographic and early-life factors in relation to early-onset T2D using a family-based design that accounts for shared genetic an

PURPOSE. Epithelial maturation is essential for the specificity and functionality of retinal pigment epithelial (RPE) cell models. This study investigates how different maturation conditions shape RPE characteristics and cellular complement biology in two commonly used in vitro models: ARPE-19 and induced pluripotent stem cell–derived RPE (iPSC-RPE). METHODS. ARPE-19 and iPSC-RPE cells were cultur

Diabetes is a growing global problem, with hundreds of millions of people living with the disease worldwide. Diabetes can be divided into two major subtypes, autoimmune type 1 diabetes (T1D), and type 2 diabetes (T2D), which has stronger causal links in obesity, lifestyle, and age. Although immunity and inflammation are clearly defined in T1D, it is also understood that inflammation has a role in

Aims/Hypothesis: Charcot foot (CF), a potentially debilitating complication of neuropathy, requires offloading to avoid foot deformities. Follow-up MRI examinations are often used to determine the optimal duration of total contact cast (TCC) offloading treatment. This study investigated the use of follow-up MRI during CF treatment and its relationship to offloading duration and risk of future surg

Pituitary tumours, originating from endocrine cells of the anterior pituitary, are quite common, and in most cases well-controlled by surgery or medical treatment. However, a small subset of pituitary tumours presents with multiple local recurrences or tumour progression despite combined surgical, medical or radiotherapeutic treatment. These are known as aggressive pituitary tumours (APT); also ca

Acute hemolytic transfusion reaction (AHTR) is a rare but life-threatening complication of transfusion. We herein report a case of anti-Jkb IgM-related AHTR. Two hours after an 80-year-old man with myelodysplastic syndrome received a packed red blood cell (RBC) A+/Rh-/Jkb+/c- transfusion, he developed acute respiratory failure and a fever. Although he had tested negative in routine screening tests

The Caledonian nappes in Scandinavia record two main phases of early Paleozoic metamorphism, but their pre-Caledonian tectonothermal history and paleogeographic position are largely unknown. Here we present a U-Pb age of 637+/-3 Ma for metamorphic titanite in the 1776+/-4 Ma (zircon age) Skarja granitic gneiss in northern Sweden. The titanite age is interpreted to represent a Neoproterozoic tecton

Embedded systems are becoming increasingly networked and aredeployed in application areas that require close interaction withtheir physical environment. Examples include distributed mobileagents and wireless sensor/actuator networks. The complexity ofthese applications make co-simulation a necessary tool during systemdevelopment. This paper presents a simulation environment thatfacilitates simulat