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In the presence of high glucose or pyruvate, INS-1 832/13 insulinoma cells undergo stochastic oscillations in plasma membrane potential (Δψp) leading to associated fluctuations in cytosolic free Ca(2+) concentration ([Ca(2+)]c). Oscillations are not driven by upstream metabolic fluctuations, but rather by autonomous ionic mechanisms, the details of which are unclear. We have investigated the natur
The understanding of multiple bubbles condensation is of significant importance in developing continuum models for the large-scale subcooled flow boiling. The computational fluid dynamics (CFD) modeling for multiple bubbles condensation is developed with the volume of fluid (VOF) method in this work. An explicit transient simulation is performed to solve the governing equations including the sourc
Immunoglobulin A (IgA) nephropathy is a chronic glomerulonephritis with excessive glomerular deposition of IgA1, C3 and C5b-9, which may lead to renal failure.
The 12-item Short-Form Health Survey (SF-12) is an abbreviated version of the SF-36, one of the most widely used patient-reported health outcome rating scales. Similar to the SF-36, it yields summary scores of physical and mental health (PCS and MCS, respectively). However, SF-36 derived PCS and MCS scores have not been found valid in neurological disorders such as Parkinson's disease (PD). Here w
Insulin is released from pancreatic beta-cells as a result of Ca(2+)-evoked exocytosis of dense-core granules. Secretion is biphasic, which has been suggested to correspond to the release of different granule pools. Here we review and carefully reanalyze previously published patch-clamp data on depolarization-evoked Ca(2+)-currents and corresponding capacitance measurements. Using a statistical mi
Introduction: Hypoadiponectinaemia is an important risk factor for non-alcoholic fatty liver disease (NAFLD). However, little is known about its role in the Chinese population. This study sought to assess the prevalence of NAFLD and its association with hypoadiponectinaemia in middle-aged and elderly Chinese. Material and methods: We conducted a population-based cross-sectional study in an urban S
Aim: To determine the prevalence and types of intrapartum cardiotocography (CTG) patterns and investigate their relationship to moderate acidemia in term fetuses of diabetic mothers. Also, to assess if the combination of fetal electrocardiogram (FECG) and those CTG patterns strengthens the association with moderate acidemia. Material and methods: The material for this study is obtained from the Sw
Enzymatic synthesis of alkyl glycosides using glycoside hydrolases is well studied, but has yet to reach industrial scale, primarily due to limited yields. Reduced water content should increase yields by limiting the unwanted hydrolytic side reaction. However, previous studies have shown that a reduction in water content surprisingly favors hydrolysis over transglycosylation. In addition, glycosid
In this article we present a survey of routing methods in Optical Burst Switching (OBS) networks We begin with a description of routing approaches and follow the discussion with a detailed classification of routing algorithms in OBS. Afterwards, we discuss common OBS network loss models that are frequently used in routing optimization. As examples of such application, we present a linear and a non
This paper examines whether a resident's estimate of five traffic-related phenomena (accident frequency, incident frequency, difficulty of crossing the street, traffic flow, and speed level) in their neighborhood may depend on factors such as gender, age, how frequently they walk along the street or on characteristics of the street. The material consists of survey data from 919 residents living al
The structure of bulk liquid water was recently probed by x-ray scattering below the temperature limit of homogeneous nucleation (TH) of ∼232 K [J. A. Sellberg et al., Nature 510, 381-384 (2014)]. Here, we utilize a similar approach to study the structure of bulk liquid water below TH using oxygen K-edge x-ray emission spectroscopy (XES). Based on previous XES experiments [T. Tokushima et al., Che
The Civil Aircraft for the Regular Investigation of the Atmosphere Based on an Instrument Container (CARIBIC) project investigates physical and chemical processes in the Earth's atmosphere using a Lufthansa Airbus long-distance passenger aircraft. After the beginning of the explosive eruption of the Eyjafjallajokull volcano on Iceland on 14 April 2010, the first CARIBIC volcano-specific measuremen
Aims: During recent years, two strategies of incretin-based therapy [glucagon-like peptide-1 (GLP-1) receptor agonism and dipeptidyl peptidase-4 (DPP-4) inhibition] have entered the market for pharmacological management of type 2 diabetes. A main indication for this therapy is as add-on to on-going metformin therapy in subjects with type 2 diabetes who have insufficient glycaemic control with metf
The purpose of this research note is to provide an empirical indication of how China's increasing role in the South Pacific has been presented in their own and other nations' media over the last 20 years. What is the tone of coverage? Which issues are salient? How does this vary by nation? What changes are there over time? This research note reports information derived from over 1000 articles publ
In this study, the residual stresses in a thermal-sprayed tungsten carbide-cobalt coating are numerically investigated after a plasma-spraying process and after a subsequent roller-burnishing process. The results from the simulations are compared to the first experimental results obtained by a classical hole-drilling method. First, effective material parameters are identified by a detailed microst
Saving time to intervention is crucial in patients with symptomatic carotid artery stenosis (SCAS). We introduced a fast-track protocol (FTP). Time frames from the onset of symptoms to intervention before and after the introduction of an FTP were analyzed. SCAS patients (403 patients/405 procedures) were evaluated according to whether surgery was performed before (group 1) or after (group 2) the i
Presently there is an abundance of sites, across media, promoting acts of communal reading (televised book clubs, web rings, publishers’ book discussion questions, etc.). This article forms a case study of what usages of reading and concurrently what reading subjects are framed in the Swedish televised book club, Malous bokklubb (Malou’s Book Club), modelled on Oprah’s Book Club in the USA and Ric
Increases in striatal activity have been suggested to mediate training-related improvements in working-memory ability. We investigated the temporal dynamics of changes in task-related brain activity following training of working memory. Participants in an experimental group and an active control group, trained on easier tasks of a constant difficulty in shorter sessions than the experimental group
With New Public Management came the idea that public organizations should be led by professional managers, rather than by professionals. This has been referred to as new managerialism. This article explores how new managerialism may affect professional autonomy in a public organization that enjoys a high – and constitutionally protected – degree of organizational autonomy. A framework distinguishi
The contribution of cell generation to physiological heart growth and maintenance in humans has been difficult to establish and has remained controversial. We report that the full complement of cardiomyocytes is established perinataly and remains stable over the human lifespan, whereas the numbers of both endothelial and mesenchymal cells increase substantially from birth to early adulthood. Analy
