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Purpose: This study aims to explore negotiations of hope in everyday life for families where a child with spinal muscular atrophy (SMA) has received a new drug treatment. Methods: A narrative design was used, drawing on interviews and participant observations in two families with children with SMA, types 1–2, to situate family experiences of hope in everyday life. Narrative analysis was used on th

Human alpha 1-m microglobulin (alpha 1-m), a low molecular weight plasma protein, was found to exert mitogenic effects on mouse lymphocytes from lymph nodes and spleen. The stimulatory effects appeared to be strain-restricted: alpha 1-m induced a varying degree of proliferation of lymphocytes from three strains, whereas one strain responded poorly. Experiments with lymphocyte subpopulations showed

Huge dynamic Stark shifts of atomic energy levels in xenon induced by high-intensity laser light have been measured by a new method based upon multiphoton ionization by a tunable femtosecond laser source. Stark-induced multiphoton resonances appear as identifiable structures in the photoelectron energy spectra. The change in the structures positions, when the photon energy is tuned, is directly re

The use of pesticides has caused pollution of surface and groundwater, soil and air across the world. Many pesticides cause health effects in humans. General populations are exposed to some degree and diet is reported to be a main source of exposure. It is important to study exposure and exposure-effect relationships in occupational groups and in general populations. For such studies, good methods

Aerococcus urinae is an emerging pathogen that causes urinary tract infections, bacteremia and infective endocarditis. The mechanisms through which A. urinae cause infection are largely unknown. The aims of this study were to describe the surface proteome of A. urinae and to analyse A. urinae genomes in search for genes encoding surface proteins. Two proteins, denoted Aerococcal surface protein (A

Heart rate turbulence (HRT) is commonly assessed by two parameters: turbulence onset (TO) and turbulence slope (TS), both obtained by averaging RR tachograms following a ventricular premature beat (VPB). It has been recently shown that a model-based detection-theoretical approach results in HRT indices outperforming TO/TS in identifying the presence or absence of HRT. The aim of this work is to ev

We use observations of M3 to constrain thermohaline mixing. This is done by matching [C/Fe] and [N/Fe] along the RGB of M3. We find our models can explain observations if it is assumed there is a spread of ∼ 0.3 - 0.4 dex in [C/Fe] in the stars in M3 from their birth. We reproduce the full spread in [C/Fe] at the tip of the RGB. Thermohaline mixing can produce a significant change in [N/Fe] as a f

Molecules containing the 33-kDa plasma protein alpha1-microglobulin were isolated from human plasma by anti-(alpha1-microglobulin) affinity chromatography. Five major bands could be seen after electrophoretic separation of the alpha1-microglobulin-containing proteins under native conditions. Immunoblotting demonstrated alpha1-microglobulin in all five bands. Two of these have been described previo

Type II collagen (CII) is a target for autoreactive T cells in both rheumatoid arthritis and the murine model collagen-induced arthritis. The determinant core of CII has been identified as CII260-270, and the alteration of this T cell epitope by posttranslational modifications is known to be critical for development of arthritis in mice. Using CII-specific T cell hybridomas we have now shown that

For decades, accessibility to the physical housing environment for people with functional limitations has been of interest politically, professionally and for the users Guidelines and norms on accessible housing design have gradually been developed, however the built environment shows serious deficits when it comes to accessibility This study addresses development of a content valid cross Nordic v

A functionally distinct subset of CD103(+) dendritic cells (DCs) has recently been identified in murine mesenteric lymph nodes (MLN) that induces enhanced FoxP3(+) T cell differentiation, retinoic acid receptor signaling, and gut-homing receptor (CCR9 and alpha 4 beta 7) expression in responding T cells. We show that this function is specific to small intestinal lamina propria (SI-LP) and MLN CD10

The aim of this study was to evaluate a new approach to inhibit complement activation triggered by biomaterial surfaces in contact with blood. In order to inhibit complement activation initiated by the classical pathway (CP), we used streptococcal M protein-derived peptides that specifically bind human C4BP, an inhibitor of the CP. The peptides were used to coat polystyrene microtiter wells which

In two recent double-blind clinical trials of fetal ventral mesencephalic cell transplants into the striatum in patients with Parkinson's disease (PD), a significant proportion of the grafted patients developed dyskinetic side effects, which were not seen in the sham operated patients. Comparison between dyskinetic and non-dyskinetic grafted patients in one of the trials suggested that an uneven p

Diagnosing myxoid soft tissue neoplasms can be challenging because of overlapping histologic features. Distinct chromosomal translocations have been identified in several myxoid sarcomas, including t(12;16)(q13;p11) FUS-DDIT3 in myxoid liposarcoma, t(7,-16)(q34;p11) FUS-CREB3L2 in low-grade fibromyxoid sarcoma, and t(9;22)(q31;q12) EWSRINR4A3 in extraskeletal myxoid chondrosarcoma. These recurrent

We start by providing an evolutionary scenario for the emergence of semantics. It is argued that the evolution of anticipatory cognition and theory of mind in the hominids opened up for cooperation about future goals. This cooperation requires symbolic communication. The meanings of the symbols are established via a "meeting of minds." The concepts in the minds of communicating individuals are mod

In this paper, we describe Langforia, a multilingual processing pipeline to annotate texts with multiple layers: formatting, parts of speech, named entities, dependencies, semantic roles, and entity links. Langforia works as a web service, where the server hosts the language processing components and the client, the input and result visualization. To annotate a text or a Wikipedia page, the user c