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SIK2 (salt-inducible kinase 2) is a member of the AMPK (AMP-activated protein kinase) family of kinases and is highly expressed in adipocytes. We investigated the regulation of SIK2 in adipocytes in response to cellular stimuli with relevance for adipocyte function and/or AMPK signalling. None of the treatments, including insulin, cAMP inducers or AICAR (5-amino-4-imidazolecarboxamide riboside), a
Anaerobic digestion (AD) of minimal nutrient-supplemented wheat straw and digestate liquor recycle was evaluated in semi-continuous processes using a novel BioReactor Simulator developed for easy accurate online normalised-gas measurement. Three scenarios (i) no recycle (NR), (ii) recycle of soluble nutrient (RSN), and (iii) recycle of nutrient and microbes (RNM) were investigated in order to eval
While intercellular communication processes are frequently characterized by switch-like transitions, the endocrine system, including the adipose tissue response to insulin, has been characterized by graded responses. Yet here individual cells from adipose tissue biopsies are best described by a switch-like transition between the basal and insulin-stimulated states for the trafficking of the glucos
Predictions of high-energy hadron activation of liquid argon in the calorimeter of A Thoroidal LHC ApparatuS (ATLAS) were carried out by folding particle flux spectra with the radionuclide production cross sections. Calculations were performed with a wide array of input data. Six sets of cross sections were folded with two sets of particle flux spectra, and the results were compared. The particle
ABSTRACT: Courses of Parkinson's disease (PD) that are complicated by weight loss result in poorer overall treatment outcome and lower quality of life. To determine the contribution of depression, which has not yet been specified in the etiology of weight loss in PD, symptomatology and anamnesis from 215 outpatients diagnosed with PD were assessed using a comprehensive battery of neuropsychiatric
Abstract The ozone (O3) decomposition in the pre-heat zone of flames can initiate and accelerate the chain-branching reactions. In the present study, formaldehyde (CH2O) was investigated by both experiment and simulation methods in methane/air laminar premixed flames under atmospheric conditions. The formaldehyde concentration profiles in the flames were measured with CH2O-PLIF. When 4500 ppm of o
Correlation coefficient of received signals across a pair of antennas is a key performance indicator for multiple-input multiple-output (MIMO) systems. For multipath environments with uniform 3D angular power spectrum, the signal correlation between two antennas can be exactly calculated from their 3D radiation patterns. When radiation patterns are unavailable, a simplified approach that only requ
This article investigates the information structure of verb-second (V2) declaratives in Swedish, German, and nonnative German. Even though almost any type of element can occur in the so-called prefield, the clause-initial preverbal position of V2 declaratives, we have found language-specific patterns in native-speaker corpora: The frequencies of prefield constituent types differ substantially betw
Monoclonal antibodies are generally produced using a generic platform approach in which several chromatographic separations assure high purity of the product. Dimerization can occur during the fermentation stage and may occur also during the downstream processing. We present here simulations in which a traditional platform approach that consist of protein A capture, followed by cation-exchange and
In Sweden, 2000 patients are diagnosed with rectal cancer annually. In 1995, the Swedish Rectal Cancer Registry (SRCR) was launched to supervise and assure the quality of the management of rectal cancer. Advances in the management of rectal cancer have reduced the local recurrence (LR) rate and improved survival. To improve the outcome further, identification of prognostic and predictive factors i
Elastic simulations of single-crystal copper nanobeams, of different cross section sizes and with crystallographic orientations [100] and [110] along their length directions, have been performed applying tensile mechanical loading. The molecular dynamics code LAMMPS was employed for the simulations. The Poisson's ratio, which is one of the fundamental measures of the elastic deformation behaviour
Background. The optimal care for patients with unresectable, non-metastatic pancreatic adenocarcinoma (PAC) is debated. We treated 17 consecutive cases with preoperative radiochemotherapy (RCT) as a means for downstaging their tumours and compared outcome with 35 patients undergoing direct surgery for primarily resectable PAC during the same time period. Methods. The patients had biopsy proven, un
Wind tunnels allow researchers to investigate animals' flight under controlled conditions, and provide easy access to the animals during flight. These increasingly popular devices can benefit integrative migration biology by allowing us to explore the links between aerodynamic theory and migration as well as the links between flight behavior and physiology. Currently, wind tunnels are being used t
This paper presents an application of multiple linear regression (MLR) to extract significant correlations between damping of electromechanical modes and system operating conditions and to forecast future damping values, based on existing day-ahead market forecasts for power flows and generation. The presented analysis uses measurements from the Nordic power system. First, a static MLR model is de
Dopamine replacement therapy is useful for treating motor symptoms in the early phase of Parkinson's disease, but it is less effective in the long term. Electrical deep-brain stimulation is a valuable complement to pharmacological treatment but involves a highly invasive surgical procedure. We found that epidural electrical stimulation of the dorsal columns in the spinal cord restores locomotion i
Aims: The aim of this study is to investigate associations of screen-time and physical activity (PA) with self-efficacy for PA, intrinsic motivation to PA and health-related quality of life (HRQoL) in Colombian schoolchildren from socioeconomically disadvantaged neighborhoods, and to compare these variables among children with normal-weight (NW), overweight (OW) and obesity (OB). Methods: In 678 s
Following a royal act, a new academic discipline, Phonetics, was officially given birth in 1947. However, it was not until November 1950 that, at Lund University, Bertil Malmberg was appointed to the first Chair of Phonetics in Sweden. Four Scandinavian experts were chosen to evaluate Malmberg’s scientific competence. The peers produced four evaluations, which constitute the central corpus for th
